Travaux scientifiques publiés avec la participation des experts PhinC
Chez PhinC, nous contribuons activement à l’avancement de la modélisation et de la simulation pharmacologique, afin d’éclairer les décisions de développement, d’optimiser les stratégies cliniques et d’accélérer l’accès des patients à de nouvelles thérapies. Retrouvez ci-dessous une sélection de publications auxquelles nos experts ont pris part ainsi que nos posters scientifiques.
Publications
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An open-label, single-arm, dose-escalating concentration–QT study to investigate the cardiac effects and safety of paroxetine in healthy adults
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Pharmacokinetics and safety of gadopiclenol in Japanese healthy volunteers.
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Comparison of rituximab induction and maintenance regimens in ANCA-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patients.
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Safety, tolerability and pharmacokinetics of DNDI-6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants.
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Mass balance, pharmacokinetics, metabolism, and excretion of radiolabeled acoziborole, a potential novel treatment for human African trypanosomiasis, following single microtracer oral dose to humans.
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Prediction of a CLDN18.2 Targeted Antibody Drug Conjugate Pharmacokinetics in Cancer Patients Using PBPK Modeling and Simulation.
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Concentration-Response Analysis of the Combination of Pyronaridine and Piperaquine on Corrected QT Interval From a Randomized, Double-Blind, Placebo-Controlled Study in Healthy Adults of African Sub-Saharan Origin.
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Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients.
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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Metabolism in Pregnant Subjects and Fetuses.
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Drug-drug interaction prediction of ziritaxestat using a physiologically based enzyme and transporter pharmacokinetic network interaction model.
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Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab.
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Pharmacokinetics, Safety, and Efficacy of Gadopiclenol in Pediatric Patients Aged 2 to 17 Years.
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Determination of the optimal single dose treatment for Acoziborole, a novel drug for the treatment of human African trypanosomiasis: First-in-human study.
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Bioavailability and cardiovascular effects of adrenaline administered by Anapen 500 μg auto-injector in healthy volunteers.
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Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selectio.
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Population pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing regimens.
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Drug-Drug Interaction Study of Benznidazole and E1224 in Healthy Male Volunteers.
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PBPK Modeling Approach to Predict the Behavior of Drugs Cleared by Kidney in Pregnant Subjects and Fetus.
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Absence of QTc prolongation in a thorough QT study with imeglimin, a first in class oral agent for type 2 diabetes mellitus.
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Randomized study of the effect of gadopiclenol, a new gadolinium-based contrast agent, on the QTc interval in healthy subjects.
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Evaluation of the effects on the QT-interval of 4 artemisinin-based combination therapies with a correction-free and heart rate-free method.
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First-in-Human, Healthy Volunteers Integrated Protocol of ETC-206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug.
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Effects of Dihydroartemisinin-Piperaquine Phosphate and Artemether-Lumefantrine on QTc Interval Prolongation.
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Bioavailability and Cardiovascular Effects of Adrenaline Administered by Anapen Autoinjector in Healthy Volunteers.
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Abstract 900: Computing tumor growth rate across pre- and post-treatment periods uncovers anti-tumor activity in patients treated by a pan-CDK inhibitor (BAY1000394)
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Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination.
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Pharmacokinetic study of a new testosterone-in-adhesive matrix patch applied every 2 days to hypogonadal men.
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Safety and pharmacokinetics of paracetamol following intravenous administration of 5 g during the first 24 h with a 2-g starting dose.
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Bioequivalence study of two Ibuprofen formulations administered intravenously in healthy male volunteers.
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Population pharmacokinetics of ibuprofen enantiomers in very premature neonates.
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Pharmacokinetics and tolerability of prulifloxacin after single oral administration.
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Multiple-dose pharmacokinetics and excretion balance of gatifloxacin, a new fluoroquinolone antibiotic, following oral administration to healthy Caucasian volunteers.
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Comparative bioavailability of two oral nimodipine formulations after administration to 24 healthy volunteers.
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Comparative bioavailability study of two omeprazole formulations after single and repeated administrations.
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High-performance liquid chromatographic determination of baclofen in human plasma.
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Pharmacokinetics of carboplatin in a patient suffering from advanced ovarian carcinoma with hemodialysis-dependent renal insufficiency.
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Continuous double administration of 5 fluorouracil (intravenous and intraperitoneal) modulated by folinic acid: phase I clinical study and pharmacokinetics in patients with intra-abdominal developing cancers.
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Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukemia: comparison of bolus administration and continuous infusion.
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Sublingual apomorphine in Parkinson’s disease: a clinical and pharmacokinetic study.
