DDI \u2014 Apport de la mod\u00e9lisation | PhinC<\/title>\r\n <style>\r\n :root{\r\n --phinc-navy:#00005f;\r\n --phinc-pink:#f947ac;\r\n --bg:#fbfafc; \/* blanc cass\u00e9 *\/\r\n --card:#ffffff;\r\n --text:#0b0b1a;\r\n --muted:#4a4a68;\r\n --border:rgba(0,0,95,.12);\r\n --shadow:0 14px 40px rgba(0,0,95,.10);\r\n --radius:18px;\r\n --radius-lg:26px;\r\n --max:1120px;\r\n --line:rgba(0,0,95,.12); \/* compat case studies *\/\r\n }\r\n\r\n *{box-sizing:border-box}\r\n html,body{height:100%}\r\n body{\r\n margin:0;\r\n font-family: ui-sans-serif, system-ui, -apple-system, Segoe UI, Roboto, Helvetica, Arial, \"Apple Color Emoji\",\"Segoe UI Emoji\";\r\n color:var(--text);\r\n background:\r\n radial-gradient(1000px 700px at 15% 0%, rgba(249,71,172,.10), transparent 60%),\r\n radial-gradient(900px 600px at 85% 10%, rgba(0,0,95,.12), transparent 55%),\r\n var(--bg);\r\n line-height:1.5;\r\n }\r\n\r\n a{color:inherit}\r\n .wrap{max-width:var(--max); margin:0 auto; padding:0 20px;}\r\n\r\n \/* Buttons *\/\r\n .btnRow{display:flex; gap:12px; flex-wrap:wrap; margin-top:16px;}\r\n .btn{\r\n display:inline-flex; align-items:center; justify-content:center;\r\n padding:12px 14px;\r\n border-radius:999px;\r\n border:1px solid var(--border);\r\n text-decoration:none;\r\n font-weight:700;\r\n font-size:14px;\r\n transition:.15s ease;\r\n background:var(--card);\r\n color:var(--phinc-navy);\r\n }\r\n .btn:hover{transform:translateY(-1px); box-shadow:0 10px 20px rgba(0,0,95,.10);}\r\n .btn.primary{\r\n background:linear-gradient(135deg, var(--phinc-navy), #14147e);\r\n color:#fff;\r\n border-color:transparent;\r\n }\r\n .btn.primary:hover{box-shadow:0 14px 26px rgba(0,0,95,.20);}\r\n .btn.secondary{\r\n background:rgba(0,0,95,.03);\r\n border-color:rgba(0,0,95,.14);\r\n color:var(--phinc-navy);\r\n }\r\n\r\n \/* Sections *\/\r\n section{padding:56px 0;}\r\n .kicker{\r\n display:inline-flex; align-items:center; gap:10px;\r\n color:var(--phinc-navy);\r\n font-weight:800;\r\n font-size:12px;\r\n letter-spacing:.18em;\r\n text-transform:uppercase;\r\n }\r\n .kicker:before{\r\n content:\"\";\r\n width:12px; height:12px; border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-pink), var(--phinc-navy));\r\n box-shadow:0 10px 18px rgba(249,71,172,.18);\r\n }\r\n h1{margin:14px 0 10px; font-size:clamp(28px, 3.2vw, 44px); line-height:1.08; color:var(--phinc-navy);}\r\n h2{margin:0 0 10px; font-size:24px; color:var(--phinc-navy); line-height:1.2;}\r\n p{margin:0; color:var(--muted); font-size:16px;}\r\n .lead{font-size:17px; color:#3f3f62; max-width:60ch; margin-top:10px;}\r\n\r\n .card{\r\n background:var(--card);\r\n border:1px solid var(--border);\r\n border-radius:var(--radius);\r\n box-shadow:var(--shadow);\r\n }\r\n\r\n \/* HERO *\/\r\n .hero{padding:54px 0 38px;}\r\n .heroGrid{\r\n display:grid;\r\n grid-template-columns: 1.05fr .95fr;\r\n gap:22px;\r\n align-items:stretch;\r\n }\r\n .heroLeft{\r\n padding:28px;\r\n border-radius:var(--radius-lg);\r\n background:\r\n linear-gradient(180deg, rgba(0,0,95,.04), rgba(249,71,172,.04)),\r\n var(--card);\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n position:relative;\r\n overflow:hidden;\r\n }\r\n .heroLeft:after{\r\n content:\"\";\r\n position:absolute; inset:-120px -180px auto auto;\r\n width:320px; height:320px;\r\n background:radial-gradient(circle at 30% 30%, rgba(249,71,172,.25), transparent 60%);\r\n transform:rotate(12deg);\r\n pointer-events:none;\r\n }\r\n\r\n .heroRight{\r\n border-radius:var(--radius-lg);\r\n overflow:hidden;\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n background:#fff;\r\n min-height:320px;\r\n display:flex;\r\n flex-direction:column;\r\n }\r\n .heroImg{\r\n width:100%;\r\n height:100%;\r\n object-fit:cover;\r\n display:block;\r\n flex:1 1 auto;\r\n }\r\n\r\n \/* Content blocks *\/\r\n .threeCols{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:18px;\r\n }\r\n .feature{\r\n padding:18px;\r\n border-radius:18px;\r\n border:1px solid var(--border);\r\n background:var(--card);\r\n box-shadow:0 10px 26px rgba(0,0,95,.08);\r\n }\r\n .feature h3{\r\n margin:0 0 8px;\r\n color:var(--phinc-navy);\r\n font-size:16px;\r\n }\r\n .feature p{font-size:14px}\r\n\r\n .sectionHead{\r\n display:flex;\r\n justify-content:space-between;\r\n gap:18px;\r\n align-items:flex-end;\r\n flex-wrap:wrap;\r\n margin-bottom:12px;\r\n }\r\n\r\n \/* CASE STUDIES (integrated styles) *\/\r\n .section{padding:56px 0;}\r\n .eyebrow{\r\n display:inline-flex; align-items:center; gap:10px;\r\n color:var(--phinc-navy);\r\n font-weight:800;\r\n font-size:12px;\r\n letter-spacing:.18em;\r\n text-transform:uppercase;\r\n }\r\n .eyebrow .dot{\r\n margin-top:0;\r\n width:12px; height:12px;\r\n border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-pink), var(--phinc-navy));\r\n }\r\n\r\n .cases{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:18px;\r\n }\r\n .case{\r\n border-radius:18px;\r\n border:1px solid var(--border);\r\n background:var(--card);\r\n box-shadow:0 10px 26px rgba(0,0,95,.08);\r\n overflow:hidden;\r\n display:flex;\r\n flex-direction:column;\r\n min-height:100%;\r\n }\r\n .case .thumb{\r\n width:100%;\r\n aspect-ratio: 3 \/ 2;\r\n background:rgba(0,0,95,.03);\r\n overflow:hidden;\r\n }\r\n .case .thumb img{\r\n width:100%;\r\n height:100%;\r\n object-fit:cover;\r\n display:block;\r\n transition:transform .18s ease;\r\n }\r\n .case:hover .thumb img{transform:scale(1.02);}\r\n .case .content{padding:16px 16px 0;}\r\n .case .content h3{\r\n margin:0 0 6px;\r\n font-size:16px;\r\n color:var(--phinc-navy);\r\n }\r\n .case .content p{font-size:14px; color:var(--muted);}\r\n .case .cta{padding:14px 16px 16px; margin-top:auto;}\r\n\r\n \/* Contact *\/\r\n .contactShell{\r\n padding:26px;\r\n border-radius:var(--radius-lg);\r\n background:\r\n radial-gradient(1000px 600px at 10% 10%, rgba(249,71,172,.10), transparent 55%),\r\n radial-gradient(900px 520px at 90% 20%, rgba(0,0,95,.10), transparent 55%),\r\n var(--card);\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .heroGrid{grid-template-columns:1fr;}\r\n .heroRight{min-height:260px;}\r\n .threeCols{grid-template-columns:1fr;}\r\n .cases{grid-template-columns:1fr;}\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n\r\n \r\n <main id=\"top\">\r\n <section class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"heroGrid\">\r\n \r\n <div class=\"heroLeft\">\r\n <div class=\"kicker\">DDI<\/div>\r\n <h2>Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai.<\/h2>\r\n <p class=\"lead\">\r\n La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI,\r\n justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements,\r\n contre-indications).\r\n <\/p>\r\n\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/fr\/contact\/\">Planifier un \u00e9change<\/a>\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir les \u00e9tudes de cas<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <figure class=\"heroRight\" aria-label=\"Visuel DDI\">\r\n <img decoding=\"async\"\r\n class=\"heroImg\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/DDI-cover-1000-x-670px.jpg\"\r\n alt=\"DDI \u2014 visuel\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/figure>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"applications-ddi\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Applications<\/div>\r\n <h2>Applications de la mod\u00e9lisation : quelles approches pour les DDI<\/h2>\r\n <p>Des analyses quantitatives pour d\u00e9cider quoi tester, comment le tester, et quoi recommander.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cperpetrator\u201d (inhibition\/induction)<\/h3>\r\n <p>Pr\u00e9dire l\u2019impact sur l\u2019exposition des substrats (AUC, Cmax), cadrer les sc\u00e9narios et le besoin d\u2019\u00e9tude clinique.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cvictim\u201d (sensibilit\u00e9 du candidat)<\/h3>\r\n <p>Quantifier la sensibilit\u00e9 aux inhibiteurs\/inducteurs, identifier les \u201cworst cases\u201d et les co-m\u00e9dications critiques.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Recommandations & label<\/h3>\r\n <p>Traduire les r\u00e9sultats en recommandations d\u00e9fendables : ajustements de dose, fen\u00eatres d\u2019administration, CI.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>PBPK & sc\u00e9narios \u201cwhat-if\u201d<\/h3>\r\n <p>Explorer enzymes\/transporteurs, polymorphismes, organ impairment, multi-perpetrators, et extrapolations.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>PopPK \/ mod\u00e9lisation int\u00e9gr\u00e9e<\/h3>\r\n <p>Exploiter donn\u00e9es cliniques (sparse\/denses), covariables, co-m\u00e9dications r\u00e9elles et variabilit\u00e9 interindividuelle.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Design & priorisation des \u00e9tudes<\/h3>\r\n <p>Choix des substrats\/inhibiteurs\/inducteurs, doses, fen\u00eatres, washout et puissance \u2014 pour un plan DDI efficient.<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"expertise\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Expertise PhinC<\/div>\r\n <h2>Une strat\u00e9gie DDI align\u00e9e donn\u00e9es, m\u00e9canismes et attentes agences<\/h2>\r\n <p>Du triage rapide \u00e0 un mod\u00e8le PBPK complet \u2014 avec des livrables exploitables pour clinique & r\u00e9glementaire.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>Lecture m\u00e9canistique<\/h3>\r\n <p>Hypoth\u00e8ses enzymes\/transporteurs, param\u00e8tres in vitro\/in vivo, incertitudes, et plan de qualification du mod\u00e8le.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Strat\u00e9gie de preuves<\/h3>\r\n <p>Quel niveau de preuve pour chaque d\u00e9cision : extrapolation, \u00e9tude d\u00e9di\u00e9e, ou analyse opportuniste.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Livrables pr\u00eats \u201csoumission\u201d<\/h3>\r\n <p>Rapports, annexes et \u00e9l\u00e9ments de justification pour interactions agences et dossiers (protocoles, SAP, CSR).<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <div class=\"section\" id=\"case-studies\" style=\"background:var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line);\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> Case studies<\/span>\r\n\r\n <div class=\"cases\">\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #1<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir l'\u00e9tude de cas<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #2<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir l'\u00e9tude de cas<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #3<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir l'\u00e9tude de cas<\/a>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <section id=\"contact\">\r\n <div class=\"wrap\">\r\n <div class=\"contactShell\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Contact<\/div>\r\n <h2>Partagez votre contexte DDI : m\u00e9canisme, donn\u00e9es, et d\u00e9cision \u00e0 s\u00e9curiser<\/h2>\r\n <p>Nous revenons vers vous avec une strat\u00e9gie claire, un timing et des livrables adapt\u00e9s (triage \u2192 mod\u00e8le \u2192 recommandations).<\/p>\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/fr\/contact\/\">\u00c9changer avec un expert<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <\/main>\r\n\r\n <script>\r\n const y = document.getElementById('year');\r\n if (y) y.textContent = new Date().getFullYear();\r\n <\/script>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>", "protected": false }, "excerpt": { "rendered": "<p>DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]<\/p>", "protected": false }, "featured_media": 0, "template": "", "meta": { "_acf_changed": false }, "domaine": [], "class_list": [ "post-2413", "service", "type-service", "status-publish", "hentry" ], "acf": [], "yoast_head": "\n<title>Interactions m\u00e9dicamenteuses (DDI) - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/fr\/service\/ddi\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/fr\/service\/ddi\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC Group\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T15:00:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/\",\"url\":\"https:\/\/www.phinc-group.com\/service\/ddi\/\",\"name\":\"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group\",\"isPartOf\":{\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\",\"datePublished\":\"2025-04-10T11:47:52+00:00\",\"dateModified\":\"2026-02-13T15:00:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.phinc-group.com\/service\/ddi\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage\",\"url\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\",\"contentUrl\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.phinc-group.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Interactions m\u00e9dicamenteuses (DDI)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#website\",\"url\":\"https:\/\/www.phinc-group.com\/fr\/\",\"name\":\"PhinC Group\",\"description\":\"Quantitative Pharmacology Solutions & Modeling\",\"publisher\":{\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.phinc-group.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#organization\",\"name\":\"PhinC Group\",\"url\":\"https:\/\/www.phinc-group.com\/fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg\",\"contentUrl\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg\",\"width\":600,\"height\":600,\"caption\":\"PhinC Group\"},\"image\":{\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/\"}}]}<\/script>\n", "yoast_head_json": { "title": "Interactions m\u00e9dicamenteuses (DDI) - PhinC Group", "robots": { "index": "index", "follow": "follow", "max-snippet": "max-snippet:-1", "max-image-preview": "max-image-preview:large", "max-video-preview": "max-video-preview:-1" }, "canonical": "https:\/\/www.phinc-group.com\/fr\/service\/ddi\/", "og_locale": "fr_FR", "og_type": "article", "og_title": "Interactions m\u00e9dicamenteuses (DDI) - PhinC Group", "og_description": "DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]", "og_url": "https:\/\/www.phinc-group.com\/fr\/service\/ddi\/", "og_site_name": "PhinC Group", "article_modified_time": "2026-02-13T15:00:46+00:00", "og_image": [ { "url": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg", "type": "", "width": "", "height": "" } ], "twitter_card": "summary_large_image", "twitter_misc": { "Dur\u00e9e de lecture estim\u00e9e": "2 minutes" }, "schema": { "@context": "https:\/\/schema.org", "@graph": [ { "@type": "WebPage", "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/", "url": "https:\/\/www.phinc-group.com\/service\/ddi\/", "name": "Interactions m\u00e9dicamenteuses (DDI) - PhinC Group", "isPartOf": { "@id": "https:\/\/www.phinc-group.com\/fr\/#website" }, "primaryImageOfPage": { "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage" }, "image": { "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage" }, "thumbnailUrl": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg", "datePublished": "2025-04-10T11:47:52+00:00", "dateModified": "2026-02-13T15:00:46+00:00", "breadcrumb": { "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb" }, "inLanguage": "fr-FR", "potentialAction": [ { "@type": "ReadAction", "target": [ "https:\/\/www.phinc-group.com\/service\/ddi\/" ] } ] }, { "@type": "ImageObject", "inLanguage": "fr-FR", "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage", "url": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg", "contentUrl": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg" }, { "@type": "BreadcrumbList", "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Accueil", "item": "https:\/\/www.phinc-group.com\/" }, { "@type": "ListItem", "position": 2, "name": "Interactions m\u00e9dicamenteuses (DDI)" } ] }, { "@type": "WebSite", "@id": "https:\/\/www.phinc-group.com\/fr\/#website", "url": "https:\/\/www.phinc-group.com\/fr\/", "name": "PhinC Group", "description": "Quantitative Pharmacology Solutions & Modeling", "publisher": { "@id": "https:\/\/www.phinc-group.com\/fr\/#organization" }, "potentialAction": [ { "@type": "SearchAction", "target": { "@type": "EntryPoint", "urlTemplate": "https:\/\/www.phinc-group.com\/fr\/?s={search_term_string}" }, "query-input": { "@type": "PropertyValueSpecification", "valueRequired": true, "valueName": "search_term_string" } } ], "inLanguage": "fr-FR" }, { "@type": "Organization", "@id": "https:\/\/www.phinc-group.com\/fr\/#organization", "name": "PhinC Group", "url": "https:\/\/www.phinc-group.com\/fr\/", "logo": { "@type": "ImageObject", "inLanguage": "fr-FR", "@id": "https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/", "url": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg", "contentUrl": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg", "width": 600, "height": 600, "caption": "PhinC Group" }, "image": { "@id": "https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/" } } ] } }, "_links": { "self": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service\/2413", "targetHints": { "allow": [ "GET" ] } } ], "collection": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service" } ], "about": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/types\/service" } ], "version-history": [ { "count": 47, "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service\/2413\/revisions" } ], "predecessor-version": [ { "id": 4079, "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service\/2413\/revisions\/4079" } ], "wp:attachment": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/media?parent=2413" } ], "wp:term": [ { "taxonomy": "domaine", "embeddable": true, "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/domaine?post=2413" } ], "curies": [ { "name": "wp", "href": "https:\/\/api.w.org\/{rel}", "templated": true } ] } }

\n\t\t\t\t

\n\t\t\t\t\t\r\n\r\n\r\n \r\n \r\n DDI \u2014 Apport de la mod\u00e9lisation | PhinC<\/title>\r\n <style>\r\n :root{\r\n --phinc-navy:#00005f;\r\n --phinc-pink:#f947ac;\r\n --bg:#fbfafc; \/* blanc cass\u00e9 *\/\r\n --card:#ffffff;\r\n --text:#0b0b1a;\r\n --muted:#4a4a68;\r\n --border:rgba(0,0,95,.12);\r\n --shadow:0 14px 40px rgba(0,0,95,.10);\r\n --radius:18px;\r\n --radius-lg:26px;\r\n --max:1120px;\r\n --line:rgba(0,0,95,.12); \/* compat case studies *\/\r\n }\r\n\r\n *{box-sizing:border-box}\r\n html,body{height:100%}\r\n body{\r\n margin:0;\r\n font-family: ui-sans-serif, system-ui, -apple-system, Segoe UI, Roboto, Helvetica, Arial, \"Apple Color Emoji\",\"Segoe UI Emoji\";\r\n color:var(--text);\r\n background:\r\n radial-gradient(1000px 700px at 15% 0%, rgba(249,71,172,.10), transparent 60%),\r\n radial-gradient(900px 600px at 85% 10%, rgba(0,0,95,.12), transparent 55%),\r\n var(--bg);\r\n line-height:1.5;\r\n }\r\n\r\n a{color:inherit}\r\n .wrap{max-width:var(--max); margin:0 auto; padding:0 20px;}\r\n\r\n \/* Buttons *\/\r\n .btnRow{display:flex; gap:12px; flex-wrap:wrap; margin-top:16px;}\r\n .btn{\r\n display:inline-flex; align-items:center; justify-content:center;\r\n padding:12px 14px;\r\n border-radius:999px;\r\n border:1px solid var(--border);\r\n text-decoration:none;\r\n font-weight:700;\r\n font-size:14px;\r\n transition:.15s ease;\r\n background:var(--card);\r\n color:var(--phinc-navy);\r\n }\r\n .btn:hover{transform:translateY(-1px); box-shadow:0 10px 20px rgba(0,0,95,.10);}\r\n .btn.primary{\r\n background:linear-gradient(135deg, var(--phinc-navy), #14147e);\r\n color:#fff;\r\n border-color:transparent;\r\n }\r\n .btn.primary:hover{box-shadow:0 14px 26px rgba(0,0,95,.20);}\r\n .btn.secondary{\r\n background:rgba(0,0,95,.03);\r\n border-color:rgba(0,0,95,.14);\r\n color:var(--phinc-navy);\r\n }\r\n\r\n \/* Sections *\/\r\n section{padding:56px 0;}\r\n .kicker{\r\n display:inline-flex; align-items:center; gap:10px;\r\n color:var(--phinc-navy);\r\n font-weight:800;\r\n font-size:12px;\r\n letter-spacing:.18em;\r\n text-transform:uppercase;\r\n }\r\n .kicker:before{\r\n content:\"\";\r\n width:12px; height:12px; border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-pink), var(--phinc-navy));\r\n box-shadow:0 10px 18px rgba(249,71,172,.18);\r\n }\r\n h1{margin:14px 0 10px; font-size:clamp(28px, 3.2vw, 44px); line-height:1.08; color:var(--phinc-navy);}\r\n h2{margin:0 0 10px; font-size:24px; color:var(--phinc-navy); line-height:1.2;}\r\n p{margin:0; color:var(--muted); font-size:16px;}\r\n .lead{font-size:17px; color:#3f3f62; max-width:60ch; margin-top:10px;}\r\n\r\n .card{\r\n background:var(--card);\r\n border:1px solid var(--border);\r\n border-radius:var(--radius);\r\n box-shadow:var(--shadow);\r\n }\r\n\r\n \/* HERO *\/\r\n .hero{padding:54px 0 38px;}\r\n .heroGrid{\r\n display:grid;\r\n grid-template-columns: 1.05fr .95fr;\r\n gap:22px;\r\n align-items:stretch;\r\n }\r\n .heroLeft{\r\n padding:28px;\r\n border-radius:var(--radius-lg);\r\n background:\r\n linear-gradient(180deg, rgba(0,0,95,.04), rgba(249,71,172,.04)),\r\n var(--card);\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n position:relative;\r\n overflow:hidden;\r\n }\r\n .heroLeft:after{\r\n content:\"\";\r\n position:absolute; inset:-120px -180px auto auto;\r\n width:320px; height:320px;\r\n background:radial-gradient(circle at 30% 30%, rgba(249,71,172,.25), transparent 60%);\r\n transform:rotate(12deg);\r\n pointer-events:none;\r\n }\r\n\r\n .heroRight{\r\n border-radius:var(--radius-lg);\r\n overflow:hidden;\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n background:#fff;\r\n min-height:320px;\r\n display:flex;\r\n flex-direction:column;\r\n }\r\n .heroImg{\r\n width:100%;\r\n height:100%;\r\n object-fit:cover;\r\n display:block;\r\n flex:1 1 auto;\r\n }\r\n\r\n \/* Content blocks *\/\r\n .threeCols{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:18px;\r\n }\r\n .feature{\r\n padding:18px;\r\n border-radius:18px;\r\n border:1px solid var(--border);\r\n background:var(--card);\r\n box-shadow:0 10px 26px rgba(0,0,95,.08);\r\n }\r\n .feature h3{\r\n margin:0 0 8px;\r\n color:var(--phinc-navy);\r\n font-size:16px;\r\n }\r\n .feature p{font-size:14px}\r\n\r\n .sectionHead{\r\n display:flex;\r\n justify-content:space-between;\r\n gap:18px;\r\n align-items:flex-end;\r\n flex-wrap:wrap;\r\n margin-bottom:12px;\r\n }\r\n\r\n \/* CASE STUDIES (integrated styles) *\/\r\n .section{padding:56px 0;}\r\n .eyebrow{\r\n display:inline-flex; align-items:center; gap:10px;\r\n color:var(--phinc-navy);\r\n font-weight:800;\r\n font-size:12px;\r\n letter-spacing:.18em;\r\n text-transform:uppercase;\r\n }\r\n .eyebrow .dot{\r\n margin-top:0;\r\n width:12px; height:12px;\r\n border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-pink), var(--phinc-navy));\r\n }\r\n\r\n .cases{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:18px;\r\n }\r\n .case{\r\n border-radius:18px;\r\n border:1px solid var(--border);\r\n background:var(--card);\r\n box-shadow:0 10px 26px rgba(0,0,95,.08);\r\n overflow:hidden;\r\n display:flex;\r\n flex-direction:column;\r\n min-height:100%;\r\n }\r\n .case .thumb{\r\n width:100%;\r\n aspect-ratio: 3 \/ 2;\r\n background:rgba(0,0,95,.03);\r\n overflow:hidden;\r\n }\r\n .case .thumb img{\r\n width:100%;\r\n height:100%;\r\n object-fit:cover;\r\n display:block;\r\n transition:transform .18s ease;\r\n }\r\n .case:hover .thumb img{transform:scale(1.02);}\r\n .case .content{padding:16px 16px 0;}\r\n .case .content h3{\r\n margin:0 0 6px;\r\n font-size:16px;\r\n color:var(--phinc-navy);\r\n }\r\n .case .content p{font-size:14px; color:var(--muted);}\r\n .case .cta{padding:14px 16px 16px; margin-top:auto;}\r\n\r\n \/* Contact *\/\r\n .contactShell{\r\n padding:26px;\r\n border-radius:var(--radius-lg);\r\n background:\r\n radial-gradient(1000px 600px at 10% 10%, rgba(249,71,172,.10), transparent 55%),\r\n radial-gradient(900px 520px at 90% 20%, rgba(0,0,95,.10), transparent 55%),\r\n var(--card);\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .heroGrid{grid-template-columns:1fr;}\r\n .heroRight{min-height:260px;}\r\n .threeCols{grid-template-columns:1fr;}\r\n .cases{grid-template-columns:1fr;}\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n\r\n \r\n <main id=\"top\">\r\n <section class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"heroGrid\">\r\n \r\n <div class=\"heroLeft\">\r\n <div class=\"kicker\">DDI<\/div>\r\n <h2>Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai.<\/h2>\r\n <p class=\"lead\">\r\n La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI,\r\n justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements,\r\n contre-indications).\r\n <\/p>\r\n\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/fr\/contact\/\">Planifier un \u00e9change<\/a>\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir les \u00e9tudes de cas<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <figure class=\"heroRight\" aria-label=\"Visuel DDI\">\r\n <img decoding=\"async\"\r\n class=\"heroImg\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/DDI-cover-1000-x-670px.jpg\"\r\n alt=\"DDI \u2014 visuel\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/figure>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"applications-ddi\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Applications<\/div>\r\n <h2>Applications de la mod\u00e9lisation : quelles approches pour les DDI<\/h2>\r\n <p>Des analyses quantitatives pour d\u00e9cider quoi tester, comment le tester, et quoi recommander.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cperpetrator\u201d (inhibition\/induction)<\/h3>\r\n <p>Pr\u00e9dire l\u2019impact sur l\u2019exposition des substrats (AUC, Cmax), cadrer les sc\u00e9narios et le besoin d\u2019\u00e9tude clinique.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cvictim\u201d (sensibilit\u00e9 du candidat)<\/h3>\r\n <p>Quantifier la sensibilit\u00e9 aux inhibiteurs\/inducteurs, identifier les \u201cworst cases\u201d et les co-m\u00e9dications critiques.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Recommandations & label<\/h3>\r\n <p>Traduire les r\u00e9sultats en recommandations d\u00e9fendables : ajustements de dose, fen\u00eatres d\u2019administration, CI.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>PBPK & sc\u00e9narios \u201cwhat-if\u201d<\/h3>\r\n <p>Explorer enzymes\/transporteurs, polymorphismes, organ impairment, multi-perpetrators, et extrapolations.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>PopPK \/ mod\u00e9lisation int\u00e9gr\u00e9e<\/h3>\r\n <p>Exploiter donn\u00e9es cliniques (sparse\/denses), covariables, co-m\u00e9dications r\u00e9elles et variabilit\u00e9 interindividuelle.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Design & priorisation des \u00e9tudes<\/h3>\r\n <p>Choix des substrats\/inhibiteurs\/inducteurs, doses, fen\u00eatres, washout et puissance \u2014 pour un plan DDI efficient.<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"expertise\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Expertise PhinC<\/div>\r\n <h2>Une strat\u00e9gie DDI align\u00e9e donn\u00e9es, m\u00e9canismes et attentes agences<\/h2>\r\n <p>Du triage rapide \u00e0 un mod\u00e8le PBPK complet \u2014 avec des livrables exploitables pour clinique & r\u00e9glementaire.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>Lecture m\u00e9canistique<\/h3>\r\n <p>Hypoth\u00e8ses enzymes\/transporteurs, param\u00e8tres in vitro\/in vivo, incertitudes, et plan de qualification du mod\u00e8le.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Strat\u00e9gie de preuves<\/h3>\r\n <p>Quel niveau de preuve pour chaque d\u00e9cision : extrapolation, \u00e9tude d\u00e9di\u00e9e, ou analyse opportuniste.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Livrables pr\u00eats \u201csoumission\u201d<\/h3>\r\n <p>Rapports, annexes et \u00e9l\u00e9ments de justification pour interactions agences et dossiers (protocoles, SAP, CSR).<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <div class=\"section\" id=\"case-studies\" style=\"background:var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line);\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> Case studies<\/span>\r\n\r\n <div class=\"cases\">\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #1<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir l'\u00e9tude de cas<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #2<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir l'\u00e9tude de cas<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #3<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/\">Voir l'\u00e9tude de cas<\/a>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <section id=\"contact\">\r\n <div class=\"wrap\">\r\n <div class=\"contactShell\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Contact<\/div>\r\n <h2>Partagez votre contexte DDI : m\u00e9canisme, donn\u00e9es, et d\u00e9cision \u00e0 s\u00e9curiser<\/h2>\r\n <p>Nous revenons vers vous avec une strat\u00e9gie claire, un timing et des livrables adapt\u00e9s (triage \u2192 mod\u00e8le \u2192 recommandations).<\/p>\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/fr\/contact\/\">\u00c9changer avec un expert<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <\/main>\r\n\r\n <script>\r\n const y = document.getElementById('year');\r\n if (y) y.textContent = new Date().getFullYear();\r\n <\/script>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>", "protected": false }, "excerpt": { "rendered": "<p>DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]<\/p>", "protected": false }, "featured_media": 0, "template": "", "meta": { "_acf_changed": false }, "domaine": [], "class_list": [ "post-2413", "service", "type-service", "status-publish", "hentry" ], "acf": [], "yoast_head": "\n<title>Interactions m\u00e9dicamenteuses (DDI) - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/fr\/service\/ddi\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/fr\/service\/ddi\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC Group\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T15:00:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/\",\"url\":\"https:\/\/www.phinc-group.com\/service\/ddi\/\",\"name\":\"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group\",\"isPartOf\":{\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\",\"datePublished\":\"2025-04-10T11:47:52+00:00\",\"dateModified\":\"2026-02-13T15:00:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.phinc-group.com\/service\/ddi\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage\",\"url\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\",\"contentUrl\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.phinc-group.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Interactions m\u00e9dicamenteuses (DDI)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#website\",\"url\":\"https:\/\/www.phinc-group.com\/fr\/\",\"name\":\"PhinC Group\",\"description\":\"Quantitative Pharmacology Solutions & Modeling\",\"publisher\":{\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.phinc-group.com\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#organization\",\"name\":\"PhinC Group\",\"url\":\"https:\/\/www.phinc-group.com\/fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg\",\"contentUrl\":\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg\",\"width\":600,\"height\":600,\"caption\":\"PhinC Group\"},\"image\":{\"@id\":\"https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/\"}}]}<\/script>\n", "yoast_head_json": { "title": "Interactions m\u00e9dicamenteuses (DDI) - PhinC Group", "robots": { "index": "index", "follow": "follow", "max-snippet": "max-snippet:-1", "max-image-preview": "max-image-preview:large", "max-video-preview": "max-video-preview:-1" }, "canonical": "https:\/\/www.phinc-group.com\/fr\/service\/ddi\/", "og_locale": "fr_FR", "og_type": "article", "og_title": "Interactions m\u00e9dicamenteuses (DDI) - PhinC Group", "og_description": "DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]", "og_url": "https:\/\/www.phinc-group.com\/fr\/service\/ddi\/", "og_site_name": "PhinC Group", "article_modified_time": "2026-02-13T15:00:46+00:00", "og_image": [ { "url": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg", "type": "", "width": "", "height": "" } ], "twitter_card": "summary_large_image", "twitter_misc": { "Dur\u00e9e de lecture estim\u00e9e": "2 minutes" }, "schema": { "@context": "https:\/\/schema.org", "@graph": [ { "@type": "WebPage", "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/", "url": "https:\/\/www.phinc-group.com\/service\/ddi\/", "name": "Interactions m\u00e9dicamenteuses (DDI) - PhinC Group", "isPartOf": { "@id": "https:\/\/www.phinc-group.com\/fr\/#website" }, "primaryImageOfPage": { "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage" }, "image": { "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage" }, "thumbnailUrl": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg", "datePublished": "2025-04-10T11:47:52+00:00", "dateModified": "2026-02-13T15:00:46+00:00", "breadcrumb": { "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb" }, "inLanguage": "fr-FR", "potentialAction": [ { "@type": "ReadAction", "target": [ "https:\/\/www.phinc-group.com\/service\/ddi\/" ] } ] }, { "@type": "ImageObject", "inLanguage": "fr-FR", "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#primaryimage", "url": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg", "contentUrl": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg" }, { "@type": "BreadcrumbList", "@id": "https:\/\/www.phinc-group.com\/service\/ddi\/#breadcrumb", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Accueil", "item": "https:\/\/www.phinc-group.com\/" }, { "@type": "ListItem", "position": 2, "name": "Interactions m\u00e9dicamenteuses (DDI)" } ] }, { "@type": "WebSite", "@id": "https:\/\/www.phinc-group.com\/fr\/#website", "url": "https:\/\/www.phinc-group.com\/fr\/", "name": "PhinC Group", "description": "Quantitative Pharmacology Solutions & Modeling", "publisher": { "@id": "https:\/\/www.phinc-group.com\/fr\/#organization" }, "potentialAction": [ { "@type": "SearchAction", "target": { "@type": "EntryPoint", "urlTemplate": "https:\/\/www.phinc-group.com\/fr\/?s={search_term_string}" }, "query-input": { "@type": "PropertyValueSpecification", "valueRequired": true, "valueName": "search_term_string" } } ], "inLanguage": "fr-FR" }, { "@type": "Organization", "@id": "https:\/\/www.phinc-group.com\/fr\/#organization", "name": "PhinC Group", "url": "https:\/\/www.phinc-group.com\/fr\/", "logo": { "@type": "ImageObject", "inLanguage": "fr-FR", "@id": "https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/", "url": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg", "contentUrl": "https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/Icone-PhinC-New_white-600px.jpg", "width": 600, "height": 600, "caption": "PhinC Group" }, "image": { "@id": "https:\/\/www.phinc-group.com\/fr\/#\/schema\/logo\/image\/" } } ] } }, "_links": { "self": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service\/2413", "targetHints": { "allow": [ "GET" ] } } ], "collection": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service" } ], "about": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/types\/service" } ], "version-history": [ { "count": 47, "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service\/2413\/revisions" } ], "predecessor-version": [ { "id": 4079, "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/service\/2413\/revisions\/4079" } ], "wp:attachment": [ { "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/media?parent=2413" } ], "wp:term": [ { "taxonomy": "domaine", "embeddable": true, "href": "https:\/\/www.phinc-group.com\/fr\/wp-json\/wp\/v2\/domaine?post=2413" } ], "curies": [ { "name": "wp", "href": "https:\/\/api.w.org\/{rel}", "templated": true } ] } }