PhinC \u2013 PBPK & PBBM (Aper\u00e7u)<\/title>\r\n<\/head>\r\n\r\n<body style=\"margin:0;background:#ffffff;\">\r\n<section class=\"phinc-pbpkpbbm\">\r\n <style>\r\n :root{\r\n --phinc-blue:#00005f;\r\n --phinc-pink:#D94B9F;\r\n --ink:#0F172A;\r\n --muted:#475569;\r\n --line:#E6EAF2;\r\n --bg:#F7F9FC; \/* gris clair *\/\r\n --card:#FFFFFF; \/* blanc *\/\r\n --radius:18px;\r\n --shadow: 0 10px 30px rgba(15, 23, 42, .08);\r\n --max:1120px;\r\n }\r\n\r\n .phinc-pbpkpbbm{\r\n font-family: inherit; \/* Inter via Elementor *\/\r\n color:var(--ink);\r\n }\r\n\r\n .phinc-wrap{\r\n max-width:var(--max);\r\n margin:0 auto;\r\n padding:6px 78px;\r\n }\r\n\r\n \/* \u2705 Alternance de fond par section *\/\r\n .phinc-sec{ padding:56px 0; }\r\n .phinc-sec.is-white{ background:#fff; }\r\n .phinc-sec.is-gray{ background:var(--bg); }\r\n\r\n \/* \u2705 S\u00e9parateur fin full-width entre sections *\/\r\n .phinc-sep{\r\n height:1px;\r\n width:100%;\r\n background:var(--line);\r\n margin:0;\r\n }\r\n\r\n .kicker{\r\n display:inline-flex;\r\n gap:10px;\r\n align-items:center;\r\n padding:6px 12px;\r\n background:rgba(217,75,159,.10);\r\n border:1px solid rgba(217,75,159,.25);\r\n color:var(--phinc-blue);\r\n border-radius:999px;\r\n font-weight:500;\r\n font-size:12px;\r\n letter-spacing:.2px;\r\n }\r\n\r\n \/* HERO (suppression arri\u00e8re-plan + contour) *\/\r\n .hero{\r\n position:relative;\r\n border-radius:0;\r\n padding:0;\r\n background:transparent;\r\n border:0;\r\n box-shadow:none;\r\n overflow:visible;\r\n }\r\n\r\n .hero-grid{\r\n display:grid;\r\n grid-template-columns: 1.2fr .8fr;\r\n gap:36px;\r\n align-items:center;\r\n }\r\n\r\n .subhead{\r\n margin-top:18px;\r\n font-size:16px;\r\n line-height:1.55;\r\n color:var(--muted);\r\n max-width:62ch;\r\n }\r\n\r\n .cta-row{\r\n display:flex;\r\n flex-wrap:wrap;\r\n gap:12px;\r\n margin-top:18px;\r\n }\r\n\r\n .btn{\r\n appearance:none;\r\n padding: 18px 16px;\r\n border:0;\r\n cursor:pointer;\r\n border-radius:14px;\r\n font-weight:700;\r\n font-size:14px;\r\n line-height:1;\r\n display:inline-flex;\r\n align-items:center;\r\n gap:10px;\r\n \r\n user-select:none;\r\n text-decoration:none;\r\n }\r\n \r\n\r\n .phinc-btn.primary{\r\n border:none;\r\n padding: 14px 16px;\r\n color:#fff;\r\n background: linear-gradient(185deg, var(--phinc-pink));\r\n \r\n }\r\n .phinc-btn.primary:hover{ transform: translateY(1px); }\r\n .phinc-btn.secondary{\r\n border: 1px solid #00005f;\r\n padding: 14px 16px;\r\n color:var(--phinc-pink);\r\n background: #fff;\r\n}\r\n.phinc-btn.secondary:hover{\r\n box-shadow: 0 4px 4px rgba(15, 23, 42, .10);\r\n transform: translateY(1px);\r\n}\r\n\r\n .hero-media{\r\n border-radius:22px;\r\n overflow:hidden;\r\n border:0;\r\n box-shadow: 0 10px 24px rgba(15,23,42,.10);\r\n background:#fff;\r\n }\r\n .hero-media img{ width:100%; height:auto; display:block; }\r\n\r\n .section-head{\r\n display:flex;\r\n justify-content:space-between;\r\n gap:20px;\r\n align-items:flex-end;\r\n margin:0 0 24px;\r\n }\r\n\r\n h2{\r\n margin:0;\r\n font-size: clamp(22px, 2.6vw, 30px);\r\n line-height:1.15;\r\n color:var(--phinc-blue);\r\n letter-spacing:-.2px;\r\n }\r\n\r\n .lead{\r\n margin:6px 0 0;\r\n color:var(--muted);\r\n line-height:1.55;\r\n max-width:78ch;\r\n font-size:15px;\r\n }\r\n\r\n .grid-2{\r\n display:grid;\r\n grid-template-columns: 1fr 1fr;\r\n gap:20px;\r\n margin-top:14px;\r\n }\r\n\r\n .grid-3{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:16px;\r\n }\r\n\r\n \r\n .card{\r\n background:;\r\n border:0; \r\n border-radius:22px;\r\n padding:18px;\r\n \r\n }\r\n\r\n \r\n .card--full{ grid-column: 1 \/ -1; }\r\n\r\n .tag{\r\n display:inline-flex;\r\n align-items:center;\r\n gap:18px;\r\n font-size:12px;\r\n font-weight:700;\r\n color:var(--phinc-pink);\r\n padding:7px 10px;\r\n border-radius:999px;\r\n background: rgba(0,0,95,.06);\r\n border:1px solid rgba(0,0,95,.10);\r\n }\r\n\r\n .tag .mini{\r\n width:8px;height:8px;border-radius:999px;background:var(--phinc-blue);\r\n box-shadow: 0 0 0 6px rgba(0,0,95,.08);\r\n }\r\n\r\n .card h3{\r\n margin:12px 0 8px;\r\n font-size:16px;\r\n line-height:1.25;\r\n color:var(--ink);\r\n }\r\n\r\n .card p{\r\n margin:0;\r\n color:var(--muted);\r\n font-size:14px;\r\n line-height:1.55;\r\n }\r\n\r\n ul.clean{\r\n margin:12px 0 0;\r\n padding:0;\r\n list-style:none;\r\n display:grid;\r\n gap:10px;\r\n }\r\n\r\n \/* \u2705 4 colonnes *\/\r\n ul.clean.clean--4col{\r\n grid-template-columns: repeat(4, 1fr);\r\n gap:12px;\r\n }\r\n\r\n .li{\r\n display:flex;\r\n gap:10px;\r\n align-items:flex-start;\r\n padding:10px 10px;\r\n background:rgba(255,255,255,.65);\r\n border:1px solid rgba(230,234,242,.9);\r\n border-radius:16px;\r\n }\r\n\r\n .li.li--stack{\r\n flex-direction:column;\r\n gap:8px;\r\n align-items:flex-start;\r\n }\r\n\r\n .tick{\r\n width:18px;height:18px;border-radius:6px;\r\n background: rgba(0,0,95,.10);\r\n border:1px solid rgba(0,0,95,.14);\r\n display:grid;\r\n place-items:center;\r\n flex:0 0 auto;\r\n margin-top:2px;\r\n }\r\n .tick svg{ width:12px;height:12px; fill: var(--phinc-blue); }\r\n\r\n .li b{\r\n display:block;\r\n font-size:13.5px;\r\n color:var(--ink);\r\n margin:0 0 2px;\r\n line-height:1.25;\r\n }\r\n .li span{\r\n display:block;\r\n font-size:13px;\r\n color:var(--muted);\r\n line-height:1.35;\r\n }\r\n\r\n .divider{\r\n height:1px;\r\n background:var(--line);\r\n margin-top:10px;\r\n }\r\n\r\n \/* \u2705 CTA final *\/\r\n .cta-final{\r\n border-radius:26px;\r\n padding:26px;\r\n background:\r\n radial-gradient(1100px 320px at 15% 0%, rgba(217,75,159,.14), transparent 55%),\r\n radial-gradient(900px 260px at 85% 10%, rgba(0,0,95,.12), transparent 55%),\r\n linear-gradient(180deg, #FFFFFF 0%, #FBFCFF 100%);\r\n box-shadow: var(--shadow);\r\n }\r\n .cta-final h3{\r\n margin:0 0 10px;\r\n font-size:20px;\r\n color:var(--phinc-blue);\r\n letter-spacing:-.2px;\r\n }\r\n .cta-final p{\r\n margin:0;\r\n color:var(--muted);\r\n font-size:14.5px;\r\n line-height:1.6;\r\n max-width:92ch;\r\n }\r\n .cta-final .cta-row{ margin-top:16px; }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .hero-grid{ grid-template-columns:1fr; }\r\n .grid-3{ grid-template-columns:1fr; }\r\n .grid-2{ grid-template-columns:1fr; }\r\n ul.clean.clean--4col{ grid-template-columns: repeat(2, 1fr); }\r\n .card--full{ grid-column:auto; }\r\n .phinc-wrap{ padding:44px 18px; }\r\n }\r\n @media (max-width: 560px){\r\n ul.clean.clean--4col{ grid-template-columns: 1fr; }\r\n }\r\n <\/style>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"hero\">\r\n <div class=\"hero-grid\">\r\n <div>\r\n <div class=\"kicker\">PBPK & PBBM \u2022 Mod\u00e9lisation m\u00e9canistique<\/div>\r\n <h2 style=\"margin-top:14px;\">Des donn\u00e9es non cliniques et du design de formulation jusqu\u2019\u00e0 la performance in vivo chez l\u2019humain.<\/h2>\r\n <p class=\"subhead\">\r\n PhinC accompagne les \u00e9quipes de d\u00e9veloppement avec des strat\u00e9gies <b>PBPK<\/b> et <b>PBBM<\/b> pour anticiper l\u2019exposition, optimiser les doses,\r\n s\u00e9curiser les d\u00e9cisions cl\u00e9s et renforcer les dossiers r\u00e9glementaires.\r\n <\/p>\r\n\r\n <div class=\"cta-row\">\r\n \r\n<a class=\"btn phinc-btn primary\" href=\"\/fr\/case-studies\/#pbpk-case-studies\">\r\n Voir nos cas d'\u00e9tudes\r\n \r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-media\" aria-label=\"Cover Phase 1\">\r\n <img decoding=\"async\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/cover-pbpk-800x533-1.jpg\"\r\n alt=\"Couverture Phase 1\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Mod\u00e9lisation pharmacocin\u00e9tique bas\u00e9e sur la physiologie (PBPK)<\/h2>\r\n <p class=\"lead\">Pour une meilleure extrapolation du non clinique vers l\u2019humain.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Qu\u2019est-ce que la PBPK<\/div>\r\n <h3>Un mod\u00e8le m\u00e9canistique de l\u2019ADME<\/h3>\r\n <p>\r\n La mod\u00e9lisation PBPK pr\u00e9dit <b>l\u2019absorption, la distribution, le m\u00e9tabolisme et l\u2019excr\u00e9tion<\/b> en int\u00e9grant les propri\u00e9t\u00e9s sp\u00e9cifiques de la mol\u00e9cule et\r\n les connaissances des syst\u00e8mes physiologiques au sein d\u2019un cadre quantitatif unique.\r\n <\/p>\r\n\r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Anatomie & physiologie<\/b><span>Repr\u00e9sentation du corps humain ou animal.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Propri\u00e9t\u00e9s physico-chimiques<\/b><span>Param\u00e8tres influen\u00e7ant la distribution et la perm\u00e9abilit\u00e9.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Biotransformation in vitro<\/b><span>Enzymes, voies m\u00e9taboliques, clairance intrins\u00e8que.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Processus de transport<\/b><span>Transport actif\/passif \u00e0 travers les tissus.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Pourquoi c\u2019est cl\u00e9<\/div>\r\n <h3>S\u00e9curiser le d\u00e9veloppement clinique pr\u00e9coce<\/h3>\r\n <p>\r\n La PBPK soutient la s\u00e9lection des doses et sch\u00e9mas posologiques en tenant explicitement compte de la physiologie,\r\n du m\u00e9tabolisme\/transport in vitro et de la variabilit\u00e9 interindividuelle \u2014 r\u00e9duisant le besoin d\u2019\u00e9tudes in vivo \u00e9tendues et acc\u00e9l\u00e9rant les d\u00e9lais.\r\n <\/p>\r\n<br><br>\r\n \r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Quand utiliser la PBPK<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>First-in-Human (FIH)<\/b><span>Tester in silico des sc\u00e9narios de doses avant ex\u00e9cution clinique.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Les DDI<\/b><span>Estimer l\u2019ampleur des interactions et soutenir la strat\u00e9gie de mitigation.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Populations sp\u00e9ciales<\/b><span>P\u00e9diatrie, insuffisance h\u00e9patique ou r\u00e9nale, et autres situations.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Alimentation & bridging<\/b><span>Effet food, changement de formulation, justification de bridging.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Donn\u00e9es souvent disponibles<\/div>\r\n <h3>Jeux de donn\u00e9es exploitables rapidement<\/h3>\r\n <p>La PK pr\u00e9clinique, les \u00e9tudes animales, ainsi que les donn\u00e9es in vitro de m\u00e9tabolisme et de transport fournissent une base solide pour d\u00e9marrer une analyse PBPK.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Livrables<\/div>\r\n <h3>Sorties claires, pr\u00eates pour le r\u00e9glementaire<\/h3>\r\n <p>Rapports de simulation, comparaisons de sc\u00e9narios, analyses de sensibilit\u00e9, tra\u00e7abilit\u00e9 des hypoth\u00e8ses et recommandations orient\u00e9es d\u00e9cision.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Plateforme<\/div>\r\n <h3>Expertise GastroPlus\u00ae<\/h3>\r\n <p>PhinC a \u00e9t\u00e9 pionnier dans l\u2019utilisation de GastroPlus\u00ae et maintient un partenariat solide avec Simulations Plus\u00ae pour d\u00e9ployer des workflows PBPK best-practice.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Mod\u00e9lisation biopharmaceutique bas\u00e9e sur la physiologie (PBBM)<\/h2>\r\n <p class=\"lead\">Pour une meilleure extrapolation du design de formulation vers la performance in vivo.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Qu\u2019est-ce que la PBBM<\/div>\r\n <h3>Mod\u00e9lisation m\u00e9canistique de l\u2019absorption & de la biodisponibilit\u00e9<\/h3>\r\n <p>\r\n La PBBM pr\u00e9dit <b>l\u2019absorption et la biodisponibilit\u00e9<\/b> en int\u00e9grant les caract\u00e9ristiques de formulation \u00e0 la physiologie gastro-intestinale,\r\n permettant un lien quantitatif entre les observations <b>in vitro<\/b> et la performance <b>in vivo<\/b>.\r\n <\/p>\r\n\r\n \r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Propri\u00e9t\u00e9s physico-chimiques<\/b><span>Solubilit\u00e9, perm\u00e9abilit\u00e9, stabilit\u00e9 (pKa, LogP).<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Mod\u00e8les de formulation<\/b><span>Dissolution, taille de particule, lib\u00e9ration.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Physiologie GI<\/b><span>pH, transit, premier passage, bile.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Variabilit\u00e9<\/b><span>\u00c2ge, pathologies GI, sous-groupes patients.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Pourquoi c\u2019est cl\u00e9<\/div>\r\n <h3>Optimiser la formulation et la strat\u00e9gie de bio\u00e9quivalence<\/h3>\r\n <p>\r\n La formulation et la fabrication d\u00e9terminent la constance de l\u2019absorption et la r\u00e9ussite en bio\u00e9quivalence.\r\n La PBBM simule l\u2019interaction entre substance active, matrice de formulation et physiologie humaine afin de guider les choix de d\u00e9veloppement.\r\n <\/p>\r\n <br><br>\r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Ce que permet la PBBM<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>CRDS<\/b><span>Sp\u00e9cifications de dissolution cliniquement pertinentes.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>VBE<\/b><span>Bio\u00e9quivalence virtuelle & bridging de formulation.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Biowaivers<\/b><span>Rationnel, effet de l\u2019alimentation, antiacides.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Criblage<\/b><span>Tester des variantes avant PK clinique.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Donn\u00e9es souvent disponibles<\/div>\r\n <h3>De l\u2019API \u00e0 la dissolution in vitro<\/h3>\r\n <p>Caract\u00e9risation de l\u2019API, profils solubilit\u00e9\/perm\u00e9abilit\u00e9, essais de dissolution multi-milieux et \u00e9valuations de vitesse de lib\u00e9ration.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Approche d\u2019\u00e9tude<\/div>\r\n <h3>Concevoir \u2192 simuler \u2192 s\u00e9curiser<\/h3>\r\n <p>\u00c9valuer in silico les options de formulation et sp\u00e9cifications de dissolution, puis prioriser les sc\u00e9narios les plus prometteurs pour les \u00e9tudes PK cliniques.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Plateforme<\/div>\r\n <h3>Workflows PBBM sous GastroPlus\u00ae<\/h3>\r\n <p>PhinC excelle dans l\u2019ex\u00e9cution de PBBM avanc\u00e9e sous GastroPlus\u00ae, soutenue par une collaboration de long terme avec Simulations Plus\u00ae.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\" id=\"cta-final\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"cta-final\">\r\n <h3>Transformez vos donn\u00e9es en d\u00e9cisions PBPK\/PBBM robustes<\/h3>\r\n <p>\r\n Avec PhinC, s\u00e9curisez vos jalons cl\u00e9s gr\u00e2ce \u00e0 une mod\u00e9lisation m\u00e9canistique ma\u00eetris\u00e9e : s\u00e9lection de dose, sc\u00e9narios FIH,\r\n strat\u00e9gie DDI, optimisation de formulation, bio\u00e9quivalence et bridging. Nos \u00e9quipes combinent <b>expertise PBPK<\/b> et <b>PBBM<\/b>\r\n pour d\u00e9livrer des analyses tra\u00e7ables, d\u00e9fendables et orient\u00e9es d\u00e9cision.\r\n <\/p>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn phinc-btn primary\" href=\"\/fr\/contact\/\">\r\n Planifier un \u00e9change\r\n <span aria-hidden=\"true\">\u2197<\/span>\r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n<\/section>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>", "protected": false }, "excerpt": { "rendered": "<p>D\u00e9veloppement optimis\u00e9 d\u00e8s la pr\u00e9-clinique jusqu\u2019aux essais de phase I\/II<\/p>", "protected": false }, "featured_media": 4009, "template": "", "meta": { "_acf_changed": false }, "domaine": [], "class_list": [ "post-1421", "service", "type-service", "status-publish", "has-post-thumbnail", "hentry" ], "acf": [], "yoast_head": "\n<title>La mod\u00e9lisation PBPK - PBBM - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/fr\/service\/pbpk\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La mod\u00e9lisation PBPK - 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\n\t\t\t\t\t\r\n\r\n\r\n \r\n \r\n PhinC \u2013 PBPK & PBBM (Aper\u00e7u)<\/title>\r\n<\/head>\r\n\r\n<body style=\"margin:0;background:#ffffff;\">\r\n<section class=\"phinc-pbpkpbbm\">\r\n <style>\r\n :root{\r\n --phinc-blue:#00005f;\r\n --phinc-pink:#D94B9F;\r\n --ink:#0F172A;\r\n --muted:#475569;\r\n --line:#E6EAF2;\r\n --bg:#F7F9FC; \/* gris clair *\/\r\n --card:#FFFFFF; \/* blanc *\/\r\n --radius:18px;\r\n --shadow: 0 10px 30px rgba(15, 23, 42, .08);\r\n --max:1120px;\r\n }\r\n\r\n .phinc-pbpkpbbm{\r\n font-family: inherit; \/* Inter via Elementor *\/\r\n color:var(--ink);\r\n }\r\n\r\n .phinc-wrap{\r\n max-width:var(--max);\r\n margin:0 auto;\r\n padding:6px 78px;\r\n }\r\n\r\n \/* \u2705 Alternance de fond par section *\/\r\n .phinc-sec{ padding:56px 0; }\r\n .phinc-sec.is-white{ background:#fff; }\r\n .phinc-sec.is-gray{ background:var(--bg); }\r\n\r\n \/* \u2705 S\u00e9parateur fin full-width entre sections *\/\r\n .phinc-sep{\r\n height:1px;\r\n width:100%;\r\n background:var(--line);\r\n margin:0;\r\n }\r\n\r\n .kicker{\r\n display:inline-flex;\r\n gap:10px;\r\n align-items:center;\r\n padding:6px 12px;\r\n background:rgba(217,75,159,.10);\r\n border:1px solid rgba(217,75,159,.25);\r\n color:var(--phinc-blue);\r\n border-radius:999px;\r\n font-weight:500;\r\n font-size:12px;\r\n letter-spacing:.2px;\r\n }\r\n\r\n \/* HERO (suppression arri\u00e8re-plan + contour) *\/\r\n .hero{\r\n position:relative;\r\n border-radius:0;\r\n padding:0;\r\n background:transparent;\r\n border:0;\r\n box-shadow:none;\r\n overflow:visible;\r\n }\r\n\r\n .hero-grid{\r\n display:grid;\r\n grid-template-columns: 1.2fr .8fr;\r\n gap:36px;\r\n align-items:center;\r\n }\r\n\r\n .subhead{\r\n margin-top:18px;\r\n font-size:16px;\r\n line-height:1.55;\r\n color:var(--muted);\r\n max-width:62ch;\r\n }\r\n\r\n .cta-row{\r\n display:flex;\r\n flex-wrap:wrap;\r\n gap:12px;\r\n margin-top:18px;\r\n }\r\n\r\n .btn{\r\n appearance:none;\r\n padding: 18px 16px;\r\n border:0;\r\n cursor:pointer;\r\n border-radius:14px;\r\n font-weight:700;\r\n font-size:14px;\r\n line-height:1;\r\n display:inline-flex;\r\n align-items:center;\r\n gap:10px;\r\n \r\n user-select:none;\r\n text-decoration:none;\r\n }\r\n \r\n\r\n .phinc-btn.primary{\r\n border:none;\r\n padding: 14px 16px;\r\n color:#fff;\r\n background: linear-gradient(185deg, var(--phinc-pink));\r\n \r\n }\r\n .phinc-btn.primary:hover{ transform: translateY(1px); }\r\n .phinc-btn.secondary{\r\n border: 1px solid #00005f;\r\n padding: 14px 16px;\r\n color:var(--phinc-pink);\r\n background: #fff;\r\n}\r\n.phinc-btn.secondary:hover{\r\n box-shadow: 0 4px 4px rgba(15, 23, 42, .10);\r\n transform: translateY(1px);\r\n}\r\n\r\n .hero-media{\r\n border-radius:22px;\r\n overflow:hidden;\r\n border:0;\r\n box-shadow: 0 10px 24px rgba(15,23,42,.10);\r\n background:#fff;\r\n }\r\n .hero-media img{ width:100%; height:auto; display:block; }\r\n\r\n .section-head{\r\n display:flex;\r\n justify-content:space-between;\r\n gap:20px;\r\n align-items:flex-end;\r\n margin:0 0 24px;\r\n }\r\n\r\n h2{\r\n margin:0;\r\n font-size: clamp(22px, 2.6vw, 30px);\r\n line-height:1.15;\r\n color:var(--phinc-blue);\r\n letter-spacing:-.2px;\r\n }\r\n\r\n .lead{\r\n margin:6px 0 0;\r\n color:var(--muted);\r\n line-height:1.55;\r\n max-width:78ch;\r\n font-size:15px;\r\n }\r\n\r\n .grid-2{\r\n display:grid;\r\n grid-template-columns: 1fr 1fr;\r\n gap:20px;\r\n margin-top:14px;\r\n }\r\n\r\n .grid-3{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:16px;\r\n }\r\n\r\n \r\n .card{\r\n background:;\r\n border:0; \r\n border-radius:22px;\r\n padding:18px;\r\n \r\n }\r\n\r\n \r\n .card--full{ grid-column: 1 \/ -1; }\r\n\r\n .tag{\r\n display:inline-flex;\r\n align-items:center;\r\n gap:18px;\r\n font-size:12px;\r\n font-weight:700;\r\n color:var(--phinc-pink);\r\n padding:7px 10px;\r\n border-radius:999px;\r\n background: rgba(0,0,95,.06);\r\n border:1px solid rgba(0,0,95,.10);\r\n }\r\n\r\n .tag .mini{\r\n width:8px;height:8px;border-radius:999px;background:var(--phinc-blue);\r\n box-shadow: 0 0 0 6px rgba(0,0,95,.08);\r\n }\r\n\r\n .card h3{\r\n margin:12px 0 8px;\r\n font-size:16px;\r\n line-height:1.25;\r\n color:var(--ink);\r\n }\r\n\r\n .card p{\r\n margin:0;\r\n color:var(--muted);\r\n font-size:14px;\r\n line-height:1.55;\r\n }\r\n\r\n ul.clean{\r\n margin:12px 0 0;\r\n padding:0;\r\n list-style:none;\r\n display:grid;\r\n gap:10px;\r\n }\r\n\r\n \/* \u2705 4 colonnes *\/\r\n ul.clean.clean--4col{\r\n grid-template-columns: repeat(4, 1fr);\r\n gap:12px;\r\n }\r\n\r\n .li{\r\n display:flex;\r\n gap:10px;\r\n align-items:flex-start;\r\n padding:10px 10px;\r\n background:rgba(255,255,255,.65);\r\n border:1px solid rgba(230,234,242,.9);\r\n border-radius:16px;\r\n }\r\n\r\n .li.li--stack{\r\n flex-direction:column;\r\n gap:8px;\r\n align-items:flex-start;\r\n }\r\n\r\n .tick{\r\n width:18px;height:18px;border-radius:6px;\r\n background: rgba(0,0,95,.10);\r\n border:1px solid rgba(0,0,95,.14);\r\n display:grid;\r\n place-items:center;\r\n flex:0 0 auto;\r\n margin-top:2px;\r\n }\r\n .tick svg{ width:12px;height:12px; fill: var(--phinc-blue); }\r\n\r\n .li b{\r\n display:block;\r\n font-size:13.5px;\r\n color:var(--ink);\r\n margin:0 0 2px;\r\n line-height:1.25;\r\n }\r\n .li span{\r\n display:block;\r\n font-size:13px;\r\n color:var(--muted);\r\n line-height:1.35;\r\n }\r\n\r\n .divider{\r\n height:1px;\r\n background:var(--line);\r\n margin-top:10px;\r\n }\r\n\r\n \/* \u2705 CTA final *\/\r\n .cta-final{\r\n border-radius:26px;\r\n padding:26px;\r\n background:\r\n radial-gradient(1100px 320px at 15% 0%, rgba(217,75,159,.14), transparent 55%),\r\n radial-gradient(900px 260px at 85% 10%, rgba(0,0,95,.12), transparent 55%),\r\n linear-gradient(180deg, #FFFFFF 0%, #FBFCFF 100%);\r\n box-shadow: var(--shadow);\r\n }\r\n .cta-final h3{\r\n margin:0 0 10px;\r\n font-size:20px;\r\n color:var(--phinc-blue);\r\n letter-spacing:-.2px;\r\n }\r\n .cta-final p{\r\n margin:0;\r\n color:var(--muted);\r\n font-size:14.5px;\r\n line-height:1.6;\r\n max-width:92ch;\r\n }\r\n .cta-final .cta-row{ margin-top:16px; }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .hero-grid{ grid-template-columns:1fr; }\r\n .grid-3{ grid-template-columns:1fr; }\r\n .grid-2{ grid-template-columns:1fr; }\r\n ul.clean.clean--4col{ grid-template-columns: repeat(2, 1fr); }\r\n .card--full{ grid-column:auto; }\r\n .phinc-wrap{ padding:44px 18px; }\r\n }\r\n @media (max-width: 560px){\r\n ul.clean.clean--4col{ grid-template-columns: 1fr; }\r\n }\r\n <\/style>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"hero\">\r\n <div class=\"hero-grid\">\r\n <div>\r\n <div class=\"kicker\">PBPK & PBBM \u2022 Mod\u00e9lisation m\u00e9canistique<\/div>\r\n <h2 style=\"margin-top:14px;\">Des donn\u00e9es non cliniques et du design de formulation jusqu\u2019\u00e0 la performance in vivo chez l\u2019humain.<\/h2>\r\n <p class=\"subhead\">\r\n PhinC accompagne les \u00e9quipes de d\u00e9veloppement avec des strat\u00e9gies <b>PBPK<\/b> et <b>PBBM<\/b> pour anticiper l\u2019exposition, optimiser les doses,\r\n s\u00e9curiser les d\u00e9cisions cl\u00e9s et renforcer les dossiers r\u00e9glementaires.\r\n <\/p>\r\n\r\n <div class=\"cta-row\">\r\n \r\n<a class=\"btn phinc-btn primary\" href=\"\/fr\/case-studies\/#pbpk-case-studies\">\r\n Voir nos cas d'\u00e9tudes\r\n \r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-media\" aria-label=\"Cover Phase 1\">\r\n <img decoding=\"async\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/cover-pbpk-800x533-1.jpg\"\r\n alt=\"Couverture Phase 1\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Mod\u00e9lisation pharmacocin\u00e9tique bas\u00e9e sur la physiologie (PBPK)<\/h2>\r\n <p class=\"lead\">Pour une meilleure extrapolation du non clinique vers l\u2019humain.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Qu\u2019est-ce que la PBPK<\/div>\r\n <h3>Un mod\u00e8le m\u00e9canistique de l\u2019ADME<\/h3>\r\n <p>\r\n La mod\u00e9lisation PBPK pr\u00e9dit <b>l\u2019absorption, la distribution, le m\u00e9tabolisme et l\u2019excr\u00e9tion<\/b> en int\u00e9grant les propri\u00e9t\u00e9s sp\u00e9cifiques de la mol\u00e9cule et\r\n les connaissances des syst\u00e8mes physiologiques au sein d\u2019un cadre quantitatif unique.\r\n <\/p>\r\n\r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Anatomie & physiologie<\/b><span>Repr\u00e9sentation du corps humain ou animal.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Propri\u00e9t\u00e9s physico-chimiques<\/b><span>Param\u00e8tres influen\u00e7ant la distribution et la perm\u00e9abilit\u00e9.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Biotransformation in vitro<\/b><span>Enzymes, voies m\u00e9taboliques, clairance intrins\u00e8que.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Processus de transport<\/b><span>Transport actif\/passif \u00e0 travers les tissus.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Pourquoi c\u2019est cl\u00e9<\/div>\r\n <h3>S\u00e9curiser le d\u00e9veloppement clinique pr\u00e9coce<\/h3>\r\n <p>\r\n La PBPK soutient la s\u00e9lection des doses et sch\u00e9mas posologiques en tenant explicitement compte de la physiologie,\r\n du m\u00e9tabolisme\/transport in vitro et de la variabilit\u00e9 interindividuelle \u2014 r\u00e9duisant le besoin d\u2019\u00e9tudes in vivo \u00e9tendues et acc\u00e9l\u00e9rant les d\u00e9lais.\r\n <\/p>\r\n<br><br>\r\n \r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Quand utiliser la PBPK<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>First-in-Human (FIH)<\/b><span>Tester in silico des sc\u00e9narios de doses avant ex\u00e9cution clinique.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Les DDI<\/b><span>Estimer l\u2019ampleur des interactions et soutenir la strat\u00e9gie de mitigation.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Populations sp\u00e9ciales<\/b><span>P\u00e9diatrie, insuffisance h\u00e9patique ou r\u00e9nale, et autres situations.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Alimentation & bridging<\/b><span>Effet food, changement de formulation, justification de bridging.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Donn\u00e9es souvent disponibles<\/div>\r\n <h3>Jeux de donn\u00e9es exploitables rapidement<\/h3>\r\n <p>La PK pr\u00e9clinique, les \u00e9tudes animales, ainsi que les donn\u00e9es in vitro de m\u00e9tabolisme et de transport fournissent une base solide pour d\u00e9marrer une analyse PBPK.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Livrables<\/div>\r\n <h3>Sorties claires, pr\u00eates pour le r\u00e9glementaire<\/h3>\r\n <p>Rapports de simulation, comparaisons de sc\u00e9narios, analyses de sensibilit\u00e9, tra\u00e7abilit\u00e9 des hypoth\u00e8ses et recommandations orient\u00e9es d\u00e9cision.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Plateforme<\/div>\r\n <h3>Expertise GastroPlus\u00ae<\/h3>\r\n <p>PhinC a \u00e9t\u00e9 pionnier dans l\u2019utilisation de GastroPlus\u00ae et maintient un partenariat solide avec Simulations Plus\u00ae pour d\u00e9ployer des workflows PBPK best-practice.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Mod\u00e9lisation biopharmaceutique bas\u00e9e sur la physiologie (PBBM)<\/h2>\r\n <p class=\"lead\">Pour une meilleure extrapolation du design de formulation vers la performance in vivo.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Qu\u2019est-ce que la PBBM<\/div>\r\n <h3>Mod\u00e9lisation m\u00e9canistique de l\u2019absorption & de la biodisponibilit\u00e9<\/h3>\r\n <p>\r\n La PBBM pr\u00e9dit <b>l\u2019absorption et la biodisponibilit\u00e9<\/b> en int\u00e9grant les caract\u00e9ristiques de formulation \u00e0 la physiologie gastro-intestinale,\r\n permettant un lien quantitatif entre les observations <b>in vitro<\/b> et la performance <b>in vivo<\/b>.\r\n <\/p>\r\n\r\n \r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Propri\u00e9t\u00e9s physico-chimiques<\/b><span>Solubilit\u00e9, perm\u00e9abilit\u00e9, stabilit\u00e9 (pKa, LogP).<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Mod\u00e8les de formulation<\/b><span>Dissolution, taille de particule, lib\u00e9ration.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Physiologie GI<\/b><span>pH, transit, premier passage, bile.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Variabilit\u00e9<\/b><span>\u00c2ge, pathologies GI, sous-groupes patients.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Pourquoi c\u2019est cl\u00e9<\/div>\r\n <h3>Optimiser la formulation et la strat\u00e9gie de bio\u00e9quivalence<\/h3>\r\n <p>\r\n La formulation et la fabrication d\u00e9terminent la constance de l\u2019absorption et la r\u00e9ussite en bio\u00e9quivalence.\r\n La PBBM simule l\u2019interaction entre substance active, matrice de formulation et physiologie humaine afin de guider les choix de d\u00e9veloppement.\r\n <\/p>\r\n <br><br>\r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Ce que permet la PBBM<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>CRDS<\/b><span>Sp\u00e9cifications de dissolution cliniquement pertinentes.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>VBE<\/b><span>Bio\u00e9quivalence virtuelle & bridging de formulation.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Biowaivers<\/b><span>Rationnel, effet de l\u2019alimentation, antiacides.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Criblage<\/b><span>Tester des variantes avant PK clinique.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Donn\u00e9es souvent disponibles<\/div>\r\n <h3>De l\u2019API \u00e0 la dissolution in vitro<\/h3>\r\n <p>Caract\u00e9risation de l\u2019API, profils solubilit\u00e9\/perm\u00e9abilit\u00e9, essais de dissolution multi-milieux et \u00e9valuations de vitesse de lib\u00e9ration.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Approche d\u2019\u00e9tude<\/div>\r\n <h3>Concevoir \u2192 simuler \u2192 s\u00e9curiser<\/h3>\r\n <p>\u00c9valuer in silico les options de formulation et sp\u00e9cifications de dissolution, puis prioriser les sc\u00e9narios les plus prometteurs pour les \u00e9tudes PK cliniques.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Plateforme<\/div>\r\n <h3>Workflows PBBM sous GastroPlus\u00ae<\/h3>\r\n <p>PhinC excelle dans l\u2019ex\u00e9cution de PBBM avanc\u00e9e sous GastroPlus\u00ae, soutenue par une collaboration de long terme avec Simulations Plus\u00ae.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\" id=\"cta-final\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"cta-final\">\r\n <h3>Transformez vos donn\u00e9es en d\u00e9cisions PBPK\/PBBM robustes<\/h3>\r\n <p>\r\n Avec PhinC, s\u00e9curisez vos jalons cl\u00e9s gr\u00e2ce \u00e0 une mod\u00e9lisation m\u00e9canistique ma\u00eetris\u00e9e : s\u00e9lection de dose, sc\u00e9narios FIH,\r\n strat\u00e9gie DDI, optimisation de formulation, bio\u00e9quivalence et bridging. Nos \u00e9quipes combinent <b>expertise PBPK<\/b> et <b>PBBM<\/b>\r\n pour d\u00e9livrer des analyses tra\u00e7ables, d\u00e9fendables et orient\u00e9es d\u00e9cision.\r\n <\/p>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn phinc-btn primary\" href=\"\/fr\/contact\/\">\r\n Planifier un \u00e9change\r\n <span aria-hidden=\"true\">\u2197<\/span>\r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n<\/section>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>", "protected": false }, "excerpt": { "rendered": "<p>D\u00e9veloppement optimis\u00e9 d\u00e8s la pr\u00e9-clinique jusqu\u2019aux essais de phase I\/II<\/p>", "protected": false }, "featured_media": 4009, "template": "", "meta": { "_acf_changed": false }, "domaine": [], "class_list": [ "post-1421", "service", "type-service", "status-publish", "has-post-thumbnail", "hentry" ], "acf": [], "yoast_head": "\n<title>La mod\u00e9lisation PBPK - PBBM - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/fr\/service\/pbpk\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La mod\u00e9lisation PBPK - 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