PhinC \u2014 Case Studies (T\u00e9l\u00e9chargement)<\/title>\r\n <style>\r\n :root{\r\n --phinc-navy:#00005f;\r\n --phinc-pink:#f947ac;\r\n --bg:#fbfafc;\r\n --card:#ffffff;\r\n --text:#0b0b1a;\r\n --muted:#4a4a68;\r\n --border:rgba(0,0,95,.12);\r\n --shadow:0 14px 40px rgba(0,0,0,.08);\r\n --radius:18px;\r\n --max:1180px;\r\n }\r\n html{scroll-behavior:smooth;}\r\n body{margin:0;font-family:system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif;background:var(--bg);color:var(--text);}\r\n a{color:inherit}\r\n .wrap{max-width:var(--max);margin:0 auto;padding:0 18px;}\r\n\r\n \/* Hero *\/\r\n .hero{padding:50px 0 50px;background:#ffffff;}\r\n .hero-grid{display:grid;grid-template-columns:1.05fr .95fr;gap:22px;align-items:stretch;}\r\n @media (max-width: 980px){.hero-grid{grid-template-columns:1fr;}}\r\n .hero-card{border:none;box-shadow:none;background:#ffffff;}\r\n .hero-body{padding:0px;\r\n max-width:53ch;\r\n }\r\n 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.btn-ghost{background:transparent;color:var(--phinc-navy);border-color:var(--border);}\r\n\r\n .hero-img{\r\n width:100%;\r\n height:100%;\r\n min-height:320px;\r\n object-fit:cover;\r\n display:block;\r\n background:#eee;\r\n }\r\n\r\n \/* Cards grid *\/\r\n .section{padding:30px 0 44px;}\r\n .section-title{display:flex;align-items:baseline;justify-content:space-between;gap:14px;margin:0 0 24px;}\r\n .section-title h2{margin:0;color:var(--phinc-navy);font-size:22px;}\r\n .section-title p{margin:0;color:var(--muted);font-size:14px;line-height:1.5;}\r\n\r\n .cards{\r\n display:grid;\r\n grid-template-columns:repeat(4, minmax(0, 1fr));\r\n gap:16px;\r\n }\r\n @media (max-width: 1100px){.cards{grid-template-columns:repeat(3, minmax(0, 1fr));}}\r\n @media (max-width: 820px){.cards{grid-template-columns:repeat(2, minmax(0, 1fr));}}\r\n @media (max-width: 520px){.cards{grid-template-columns:1fr;}}\r\n\r\n .card{\r\n background:var(--card);\r\n border:1px solid var(--border);\r\n border-radius:var(--radius);\r\n box-shadow:var(--shadow);\r\n overflow:hidden;\r\n display:flex;\r\n flex-direction:column;\r\n min-height:100%;\r\n }\r\n .card img{\r\n width:100%;\r\n height:160px;\r\n object-fit:cover;\r\n display:block;\r\n background:#eee;\r\n }\r\n .card-body{padding:16px;display:flex;flex-direction:column;gap:10px;flex:1;}\r\n .tag{color:var(--phinc-pink);font-weight:800;font-size:12px;letter-spacing:.02em;margin:0;}\r\n .card h3{margin:0;color:var(--phinc-navy);font-size:16px;line-height:1.25;}\r\n .card p{margin:0;color:var(--muted);font-size:13px;line-height:1.55;}\r\n .card .card-cta{margin-top:auto;display:flex;gap:10px;flex-wrap:wrap;}\r\n .btn-sm{padding:10px 12px;border-radius:12px;font-weight:800;font-size:13px;}\r\n .section-divider{max-width:1180px;margin:20px auto;height:1px;background:rgba(0,0,0,0.08);}\r\n\r\n \/* Form section *\/\r\n .form-section{padding:8px 0 70px;}\r\n .form-card{\r\n background:var(--card);\r\n border:1px solid var(--border);\r\n border-radius:var(--radius);\r\n box-shadow:var(--shadow);\r\n overflow:hidden;\r\n }\r\n .form-head{padding:22px 22px 0;}\r\n .form-head h2{margin:0 0 6px;color:var(--phinc-navy);font-size:22px;}\r\n .form-head p{margin:0 0 14px;color:var(--muted);font-size:14px;line-height:1.55;}\r\n form{padding:0 22px 22px;}\r\n .fields{display:grid;grid-template-columns:1fr 1fr;gap:12px;}\r\n @media (max-width: 640px){.fields{grid-template-columns:1fr;}}\r\n .field label{display:block;font-size:13px;font-weight:800;color:var(--text);margin:0 0 6px;}\r\n .field input, .field select{\r\n width:100%;\r\n padding:11px 12px;\r\n border-radius:12px;\r\n border:1px solid var(--border);\r\n outline:none;\r\n font-size:14px;\r\n background:#fff;\r\n color:var(--text);\r\n }\r\n .field input:focus, .field select:focus{\r\n border-color:rgba(249,71,172,.55);\r\n box-shadow:0 0 0 4px rgba(249,71,172,.12);\r\n }\r\n .full{grid-column:1 \/ -1;}\r\n .checks{margin-top:12px;display:grid;gap:10px;}\r\n .check{display:flex;gap:10px;align-items:flex-start;color:var(--muted);font-size:13px;line-height:1.45;}\r\n .check input{margin-top:2px;transform:scale(1.05);}\r\n .check a{color:var(--phinc-navy);text-decoration:underline;}\r\n .req{color:var(--phinc-pink);}\r\n .success{\r\n display:none;\r\n margin:12px 22px 0;\r\n padding:12px 14px;\r\n border-radius:14px;\r\n border:1px solid rgba(0,0,95,.14);\r\n background:#fff;\r\n color:var(--text);\r\n font-size:13px;\r\n line-height:1.45;\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n \r\n <header class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"hero-grid\">\r\n <div class=\"hero-card\">\r\n <div class=\"hero-body\">\r\n <h2>Des cas r\u00e9els pour illustrer l\u2019impact de la mod\u00e9lisation<\/h2>\r\n\r\n <p class=\"lead\">\r\n Ces case studies sont issus de <strong>projets de mod\u00e9lisation men\u00e9s par PhinC<\/strong>\r\n pour des biotechs et des pharmas, \u00e0 diff\u00e9rentes \u00e9tapes du d\u00e9veloppement.\r\n <\/p>\r\n\r\n <ul class=\"hero-bullets\">\r\n <li><strong>La mol\u00e9cule et son contexte de d\u00e9veloppement<\/strong><\/li>\r\n <li><strong>La probl\u00e9matique scientifique ou clinique du client<\/strong><\/li>\r\n <li><strong>L\u2019approche mise en \u0153uvre par PhinC<\/strong> (PopPK, PK\/PD, PBPK...)<\/li>\r\n <li><strong>L\u2019apport concret de la mod\u00e9lisation<\/strong> : d\u00e9cisions \u00e9clair\u00e9es, strat\u00e9gie de dose,\r\n design d\u2019\u00e9tude optimis\u00e9, justification r\u00e9glementaire, etc.<\/li>\r\n <\/ul>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn btn-ghost\" href=\"#pbpk-case-studies\">Voir nos cas d'\u00e9tudes<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-card\" aria-label=\"Illustration hero\">\r\n <img decoding=\"async\" class=\"hero-img\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2024\/12\/shutterstock_407609158.jpg\"\r\n alt=\"Illustration pharmacom\u00e9trie\"\r\n loading=\"lazy\" \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/header>\r\n\r\n \r\n <main class=\"section\" id=\"pbpk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Faites progresser votre strat\u00e9gie DDI et FIH gr\u00e2ce \u00e0 l\u2019expertise PBPK de PhinC<\/h2>\r\n <\/div>\r\n <p>Que vous pr\u00e9pariez une \u00e9tude First-in-Human, \u00e9valuiez les risques li\u00e9s aux enzymes et transporteurs, ou construisiez une strat\u00e9gie DDI pr\u00eate pour le r\u00e9glementaire, la m\u00e9thodologie PBPK de PhinC et sa Standard Library vous apportent les \u00e9clairages m\u00e9canistiques n\u00e9cessaires \u00e0 des d\u00e9cisions en toute confiance.<br><br> <b>D\u00e9couvrez la valeur ajout\u00e9e de notre approche.<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI Prediction using pre-clinical data only<\/h3>\r\n <p>Le sponsor avait besoin d\u2019une \u00e9valuation pr\u00e9coce du risque de DDI chez l\u2019humain afin d\u2019appuyer le choix de dose FIH et la planification clinique.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\"\r\n href=\"#download-form\"\r\n data-case=\"CS01\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI_Prediction-using-pre-clinical-data.pdf\">\r\n T\u00e9l\u00e9charger le PDF\r\n <\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI exploration for a drug with complex pharmacokinetics<\/h3>\r\n <p>Le sponsor avait besoin d\u2019une compr\u00e9hension m\u00e9canistique des DDI afin d\u2019anticiper le risque clinique et d\u2019orienter la poursuite du d\u00e9veloppement.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS02\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI-Exploration-for-a-drug-with-Complex-Pharmacokinetics.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Mechanism identification of complex DDI using PBPK<\/h3>\r\n <p>Le sponsor devait caract\u00e9riser des interactions m\u00e9dicamenteuses complexes (DDI) impliquant plusieurs m\u00e9dicaments co-administr\u00e9s.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS03\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Mechanism-Identification-of-Complex-DDI.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 4\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Network interaction PBPK modeling for complex victim-perpetrator DDIs<\/h3>\r\n <p>Un programme de d\u00e9veloppement visant \u00e0 pr\u00e9dire avec pr\u00e9cision les interactions m\u00e9dicamenteuses (DDI) pour une mol\u00e9cule \u00ab X \u00bb.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS04\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Modeling-for-Complex-Victim-Perpetrator-DDI.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 5\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>PBPK model development and comprehensive DDI assessment of oral solution <\/h3>\r\n <p>Le sponsor avait besoin d\u2019un mod\u00e8le PBPK robuste et pr\u00eat pour les exigences r\u00e9glementaires afin de soutenir l\u2019\u00e9valuation du risque DDI.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS05\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Model-Development-and-Comprehensive-DDI-Assessment-of-Oral-Solution.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 6\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 FIH<\/p>\r\n <h3>PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/h3>\r\n <p>Un programme de d\u00e9veloppement n\u00e9cessitait une pr\u00e9diction fiable de la dose First-in-Human (FIH), bas\u00e9e uniquement sur des donn\u00e9es pharmacocin\u00e9tiques pr\u00e9cliniques.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS06\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/PBPK-Modeling-Using-Pre-Clinical-Data-for-FIH-Translation.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n <div class=\"section-divider\"><\/div>\r\n\r\n \r\n <main class=\"section\" id=\"poppk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Transformez vos donn\u00e9es cliniques en d\u00e9cisions gr\u00e2ce \u00e0 l\u2019approche PopPK <\/h2>\r\n <\/div>\r\n <p>Que vous cherchiez \u00e0 comprendre la variabilit\u00e9 interindividuelle, \u00e0 identifier les covariables cliniquement pertinentes, ou \u00e0 optimiser la s\u00e9lection de dose pour vos \u00e9tudes Phase II\/III, l\u2019approche PopPK de PhinC vous apporte les \u00e9clairages quantitatifs n\u00e9cessaires \u00e0 des d\u00e9cisions robustes et align\u00e9es avec vos enjeux r\u00e9glementaires.<br><br> <b>D\u00e9couvrez la valeur ajout\u00e9e de notre approche.<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 7\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>An iterative, Population PK approach to inform Dosing\r\nStrategy in Human African Trypanosomiasis (HAT)<\/h3>\r\n <p>D\u00e9finition d'un sch\u00e9ma posologique optimal de l'IMP et et une strat\u00e9gie d'\u00e9chantillonnage PK efficace pour les adultes atteints de trypanosomiase humaine africaine (THA)<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS07\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-to-Inform-Dosing-Strategy-in-Human-African-Trypanosomiasis.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 8\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III <\/h3>\r\n <p>Le sponsor a demand\u00e9 le d\u00e9veloppement d\u2019un mod\u00e8le PopPK complet bas\u00e9 sur une population p\u00e9diatrique atteinte de HAT (Phase III).<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS08\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-Modeling-to-Inform-Pediatric-Dosing-in-Human-African-Trypanosomiasis-in-Phase-3.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n \r\n <section class=\"form-section\" id=\"download-form\">\r\n <div class=\"wrap\">\r\n <div class=\"form-card\">\r\n <div class=\"form-head\">\r\n <h2>Demander une \u00e9tude de cas<\/h2>\r\n <p>Renseignez vos informations pour recevoir un email avec le lien de t\u00e9l\u00e9chargement.<\/p>\r\n <\/div>\r\n\r\n <div class=\"success\" id=\"successBox\" style=\"display:none;\">\r\n \u2705 Thank you for your interest in our work. You should receive your download link by email within the next few minutes.\r\n <br><span style=\"opacity:.85;\">If you don\u2019t see it, please check your spam folder.<\/span>\r\n <\/div>\r\n\r\n \r\n <form id=\"phincForm\" action=\"https:\/\/www.phinc-group.com\/wp-admin\/admin-post.php\" method=\"post\">\r\n <input type=\"hidden\" name=\"action\" value=\"phinc_send_case_study\">\r\n <input type=\"hidden\" id=\"pdf_link\" name=\"pdf_link\" value=\"\">\r\n <input type=\"hidden\" id=\"case_code\" name=\"case_code\" value=\"\">\r\n\r\n <div class=\"fields\">\r\n <div class=\"field\">\r\n <label for=\"firstname\">Pr\u00e9nom <span class=\"req\">*<\/span><\/label>\r\n <input id=\"firstname\" name=\"firstname\" type=\"text\" autocomplete=\"given-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field\">\r\n <label for=\"lastname\">Nom <span class=\"req\">*<\/span><\/label>\r\n <input id=\"lastname\" name=\"lastname\" type=\"text\" autocomplete=\"family-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"company\">Soci\u00e9t\u00e9 <span class=\"req\">*<\/span><\/label>\r\n <input id=\"company\" name=\"company\" type=\"text\" autocomplete=\"organization\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"email\">Adresse mail <span class=\"req\">*<\/span><\/label>\r\n <input id=\"email\" name=\"email\" type=\"email\" autocomplete=\"email\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"case_selected\">Etude de cas s\u00e9lectionn\u00e9e<\/label>\r\n <select id=\"case_selected\" name=\"case_selected\">\r\n <option value=\"\">Choisir <\/option>\r\n <option value=\"CS01\">CS01 \u2014 DDI Prediction Using Pre-Clinical Data Only<\/option>\r\n <option value=\"CS02\">CS02 \u2014 DDI Exploration for a drug with Complex Pharmacokinetics<\/option>\r\n <option value=\"CS03\">CS03 \u2014 Mechanism Identification of Complex DDI using Predictive PBPK Modeling<\/option>\r\n <option value=\"CS04\">CS04 \u2014 Network Interaction PBPK Modeling for Complex Victim-Perpetrator DDIs<\/option>\r\n <option value=\"CS05\">CS05 \u2014 PBPK Model Development and Comprehensive DDI Assessment of Oral Solution<\/option>\r\n <option value=\"CS06\">CS06 \u2014 PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/option>\r\n <option value=\"CS07\">CS07 \u2014 An iterative, Population PK approach to inform Dosing Strategy in Human African Trypanosomiasis (HAT)<\/option>\r\n<option value=\"CS08\">CS08 \u2014 Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III development.<\/option>\r\n \r\n <\/select>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"checks\">\r\n <label class=\"check\">\r\n <input type=\"checkbox\" name=\"privacy\" value=\"1\" required>\r\n <span>\r\n J\u2019ai lu et j\u2019accepte la\r\n <a href=\"\/fr\/politique-de-confidentialite\/\" target=\"_blank\" rel=\"noopener\">politique de confidentialit\u00e9<\/a>\r\n de PhinC <span class=\"req\">*<\/span>\r\n <\/span>\r\n <\/label>\r\n\r\n <label class=\"check\">\r\n <input type=\"checkbox\" name=\"contact_optin\" value=\"1\">\r\n <span>J\u2019accepte d\u2019\u00eatre contact\u00e9(e) par PhinC au sujet de ses services.<\/span>\r\n <\/label>\r\n <\/div>\r\n\r\n <button class=\"btn btn-primary\" type=\"submit\" style=\"margin-top:24px;width:20%;\">\r\n Recevoir l'\u00e9tude de cas\r\n <\/button>\r\n <\/form>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <script>\r\n (function(){\r\n \/\/ 1) Show thank-you message if sent=1\r\n const params = new URLSearchParams(window.location.search);\r\n if (params.get('sent') === '1') {\r\n const box = document.getElementById('successBox');\r\n if (box) box.style.display = 'block';\r\n }\r\n\r\n \/\/ 2) Pre-fill selected case when clicking a card CTA\r\n const select = document.getElementById('case_selected');\r\n const pdfInput = document.getElementById('pdf_link');\r\n const caseInput = document.getElementById('case_code');\r\n const downloadLinks = document.querySelectorAll('.phinc-download');\r\n\r\n downloadLinks.forEach(a => {\r\n a.addEventListener('click', () => {\r\n const code = a.getAttribute('data-case') || '';\r\n const pdf = a.getAttribute('data-pdf') || '';\r\n if (select && code) select.value = code;\r\n if (pdfInput) pdfInput.value = pdf;\r\n if (caseInput) caseInput.value = code;\r\n });\r\n });\r\n })();\r\n <\/script>\r\n\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>", "protected": false }, "excerpt": { "rendered": "<p>Real projects, real impact \u2014 explore how PhinC’s modeling expertise has shaped drug development strategies across therapeutic areas and development stages.<\/p>", "protected": false }, "author": 2, "featured_media": 4548, "parent": 0, "menu_order": 0, "comment_status": "closed", "ping_status": "closed", "template": "", "meta": { "_acf_changed": false, "footnotes": "" }, "class_list": 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\n\t\t\t\t\t\r\n\r\n\r\n \r\n \r\n PhinC \u2014 Case Studies (T\u00e9l\u00e9chargement)<\/title>\r\n <style>\r\n :root{\r\n --phinc-navy:#00005f;\r\n --phinc-pink:#f947ac;\r\n --bg:#fbfafc;\r\n --card:#ffffff;\r\n --text:#0b0b1a;\r\n --muted:#4a4a68;\r\n --border:rgba(0,0,95,.12);\r\n --shadow:0 14px 40px rgba(0,0,0,.08);\r\n --radius:18px;\r\n --max:1180px;\r\n }\r\n html{scroll-behavior:smooth;}\r\n body{margin:0;font-family:system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif;background:var(--bg);color:var(--text);}\r\n a{color:inherit}\r\n .wrap{max-width:var(--max);margin:0 auto;padding:0 18px;}\r\n\r\n \/* Hero *\/\r\n .hero{padding:50px 0 50px;background:#ffffff;}\r\n .hero-grid{display:grid;grid-template-columns:1.05fr .95fr;gap:22px;align-items:stretch;}\r\n @media (max-width: 980px){.hero-grid{grid-template-columns:1fr;}}\r\n .hero-card{border:none;box-shadow:none;background:#ffffff;}\r\n .hero-body{padding:0px;\r\n max-width:53ch;\r\n }\r\n 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.checks{margin-top:12px;display:grid;gap:10px;}\r\n .check{display:flex;gap:10px;align-items:flex-start;color:var(--muted);font-size:13px;line-height:1.45;}\r\n .check input{margin-top:2px;transform:scale(1.05);}\r\n .check a{color:var(--phinc-navy);text-decoration:underline;}\r\n .req{color:var(--phinc-pink);}\r\n .success{\r\n display:none;\r\n margin:12px 22px 0;\r\n padding:12px 14px;\r\n border-radius:14px;\r\n border:1px solid rgba(0,0,95,.14);\r\n background:#fff;\r\n color:var(--text);\r\n font-size:13px;\r\n line-height:1.45;\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n \r\n <header class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"hero-grid\">\r\n <div class=\"hero-card\">\r\n <div class=\"hero-body\">\r\n <h2>Des cas r\u00e9els pour illustrer l\u2019impact de la mod\u00e9lisation<\/h2>\r\n\r\n <p class=\"lead\">\r\n Ces case studies sont issus de <strong>projets de mod\u00e9lisation men\u00e9s par PhinC<\/strong>\r\n pour des biotechs et des pharmas, \u00e0 diff\u00e9rentes \u00e9tapes du d\u00e9veloppement.\r\n <\/p>\r\n\r\n <ul class=\"hero-bullets\">\r\n <li><strong>La mol\u00e9cule et son contexte de d\u00e9veloppement<\/strong><\/li>\r\n <li><strong>La probl\u00e9matique scientifique ou clinique du client<\/strong><\/li>\r\n <li><strong>L\u2019approche mise en \u0153uvre par PhinC<\/strong> (PopPK, PK\/PD, PBPK...)<\/li>\r\n <li><strong>L\u2019apport concret de la mod\u00e9lisation<\/strong> : d\u00e9cisions \u00e9clair\u00e9es, strat\u00e9gie de dose,\r\n design d\u2019\u00e9tude optimis\u00e9, justification r\u00e9glementaire, etc.<\/li>\r\n <\/ul>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn btn-ghost\" href=\"#pbpk-case-studies\">Voir nos cas d'\u00e9tudes<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-card\" aria-label=\"Illustration hero\">\r\n <img decoding=\"async\" class=\"hero-img\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2024\/12\/shutterstock_407609158.jpg\"\r\n alt=\"Illustration pharmacom\u00e9trie\"\r\n loading=\"lazy\" \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/header>\r\n\r\n \r\n <main class=\"section\" id=\"pbpk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Faites progresser votre strat\u00e9gie DDI et FIH gr\u00e2ce \u00e0 l\u2019expertise PBPK de PhinC<\/h2>\r\n <\/div>\r\n <p>Que vous pr\u00e9pariez une \u00e9tude First-in-Human, \u00e9valuiez les risques li\u00e9s aux enzymes et transporteurs, ou construisiez une strat\u00e9gie DDI pr\u00eate pour le r\u00e9glementaire, la m\u00e9thodologie PBPK de PhinC et sa Standard Library vous apportent les \u00e9clairages m\u00e9canistiques n\u00e9cessaires \u00e0 des d\u00e9cisions en toute confiance.<br><br> <b>D\u00e9couvrez la valeur ajout\u00e9e de notre approche.<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI Prediction using pre-clinical data only<\/h3>\r\n <p>Le sponsor avait besoin d\u2019une \u00e9valuation pr\u00e9coce du risque de DDI chez l\u2019humain afin d\u2019appuyer le choix de dose FIH et la planification clinique.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\"\r\n href=\"#download-form\"\r\n data-case=\"CS01\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI_Prediction-using-pre-clinical-data.pdf\">\r\n T\u00e9l\u00e9charger le PDF\r\n <\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI exploration for a drug with complex pharmacokinetics<\/h3>\r\n <p>Le sponsor avait besoin d\u2019une compr\u00e9hension m\u00e9canistique des DDI afin d\u2019anticiper le risque clinique et d\u2019orienter la poursuite du d\u00e9veloppement.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS02\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI-Exploration-for-a-drug-with-Complex-Pharmacokinetics.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Mechanism identification of complex DDI using PBPK<\/h3>\r\n <p>Le sponsor devait caract\u00e9riser des interactions m\u00e9dicamenteuses complexes (DDI) impliquant plusieurs m\u00e9dicaments co-administr\u00e9s.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS03\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Mechanism-Identification-of-Complex-DDI.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 4\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Network interaction PBPK modeling for complex victim-perpetrator DDIs<\/h3>\r\n <p>Un programme de d\u00e9veloppement visant \u00e0 pr\u00e9dire avec pr\u00e9cision les interactions m\u00e9dicamenteuses (DDI) pour une mol\u00e9cule \u00ab X \u00bb.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS04\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Modeling-for-Complex-Victim-Perpetrator-DDI.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 5\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>PBPK model development and comprehensive DDI assessment of oral solution <\/h3>\r\n <p>Le sponsor avait besoin d\u2019un mod\u00e8le PBPK robuste et pr\u00eat pour les exigences r\u00e9glementaires afin de soutenir l\u2019\u00e9valuation du risque DDI.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS05\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Model-Development-and-Comprehensive-DDI-Assessment-of-Oral-Solution.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 6\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 FIH<\/p>\r\n <h3>PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/h3>\r\n <p>Un programme de d\u00e9veloppement n\u00e9cessitait une pr\u00e9diction fiable de la dose First-in-Human (FIH), bas\u00e9e uniquement sur des donn\u00e9es pharmacocin\u00e9tiques pr\u00e9cliniques.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS06\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/PBPK-Modeling-Using-Pre-Clinical-Data-for-FIH-Translation.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n <div class=\"section-divider\"><\/div>\r\n\r\n \r\n <main class=\"section\" id=\"poppk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Transformez vos donn\u00e9es cliniques en d\u00e9cisions gr\u00e2ce \u00e0 l\u2019approche PopPK <\/h2>\r\n <\/div>\r\n <p>Que vous cherchiez \u00e0 comprendre la variabilit\u00e9 interindividuelle, \u00e0 identifier les covariables cliniquement pertinentes, ou \u00e0 optimiser la s\u00e9lection de dose pour vos \u00e9tudes Phase II\/III, l\u2019approche PopPK de PhinC vous apporte les \u00e9clairages quantitatifs n\u00e9cessaires \u00e0 des d\u00e9cisions robustes et align\u00e9es avec vos enjeux r\u00e9glementaires.<br><br> <b>D\u00e9couvrez la valeur ajout\u00e9e de notre approche.<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 7\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>An iterative, Population PK approach to inform Dosing\r\nStrategy in Human African Trypanosomiasis (HAT)<\/h3>\r\n <p>D\u00e9finition d'un sch\u00e9ma posologique optimal de l'IMP et et une strat\u00e9gie d'\u00e9chantillonnage PK efficace pour les adultes atteints de trypanosomiase humaine africaine (THA)<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS07\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-to-Inform-Dosing-Strategy-in-Human-African-Trypanosomiasis.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 8\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III <\/h3>\r\n <p>Le sponsor a demand\u00e9 le d\u00e9veloppement d\u2019un mod\u00e8le PopPK complet bas\u00e9 sur une population p\u00e9diatrique atteinte de HAT (Phase III).<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS08\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-Modeling-to-Inform-Pediatric-Dosing-in-Human-African-Trypanosomiasis-in-Phase-3.pdf\">T\u00e9l\u00e9charger le PDF<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n \r\n <section class=\"form-section\" id=\"download-form\">\r\n <div class=\"wrap\">\r\n <div class=\"form-card\">\r\n <div class=\"form-head\">\r\n <h2>Demander une \u00e9tude de cas<\/h2>\r\n <p>Renseignez vos informations pour recevoir un email avec le lien de t\u00e9l\u00e9chargement.<\/p>\r\n <\/div>\r\n\r\n <div class=\"success\" id=\"successBox\" style=\"display:none;\">\r\n \u2705 Thank you for your interest in our work. You should receive your download link by email within the next few minutes.\r\n <br><span style=\"opacity:.85;\">If you don\u2019t see it, please check your spam folder.<\/span>\r\n <\/div>\r\n\r\n \r\n <form id=\"phincForm\" action=\"https:\/\/www.phinc-group.com\/wp-admin\/admin-post.php\" method=\"post\">\r\n <input type=\"hidden\" name=\"action\" value=\"phinc_send_case_study\">\r\n <input type=\"hidden\" id=\"pdf_link\" name=\"pdf_link\" value=\"\">\r\n <input type=\"hidden\" id=\"case_code\" name=\"case_code\" value=\"\">\r\n\r\n <div class=\"fields\">\r\n <div class=\"field\">\r\n <label for=\"firstname\">Pr\u00e9nom <span class=\"req\">*<\/span><\/label>\r\n <input id=\"firstname\" name=\"firstname\" type=\"text\" autocomplete=\"given-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field\">\r\n <label for=\"lastname\">Nom <span class=\"req\">*<\/span><\/label>\r\n <input id=\"lastname\" name=\"lastname\" type=\"text\" autocomplete=\"family-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"company\">Soci\u00e9t\u00e9 <span class=\"req\">*<\/span><\/label>\r\n <input id=\"company\" name=\"company\" type=\"text\" autocomplete=\"organization\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"email\">Adresse mail <span class=\"req\">*<\/span><\/label>\r\n <input id=\"email\" name=\"email\" type=\"email\" autocomplete=\"email\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"case_selected\">Etude de cas s\u00e9lectionn\u00e9e<\/label>\r\n <select id=\"case_selected\" name=\"case_selected\">\r\n <option value=\"\">Choisir <\/option>\r\n <option value=\"CS01\">CS01 \u2014 DDI Prediction Using Pre-Clinical Data Only<\/option>\r\n <option value=\"CS02\">CS02 \u2014 DDI Exploration for a drug with Complex Pharmacokinetics<\/option>\r\n <option value=\"CS03\">CS03 \u2014 Mechanism Identification of Complex DDI using Predictive PBPK Modeling<\/option>\r\n <option value=\"CS04\">CS04 \u2014 Network Interaction PBPK Modeling for Complex Victim-Perpetrator DDIs<\/option>\r\n <option value=\"CS05\">CS05 \u2014 PBPK Model Development and Comprehensive DDI Assessment of Oral Solution<\/option>\r\n <option value=\"CS06\">CS06 \u2014 PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/option>\r\n <option value=\"CS07\">CS07 \u2014 An iterative, Population PK approach to inform Dosing Strategy in Human African Trypanosomiasis (HAT)<\/option>\r\n<option value=\"CS08\">CS08 \u2014 Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III development.<\/option>\r\n \r\n <\/select>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"checks\">\r\n <label class=\"check\">\r\n <input type=\"checkbox\" name=\"privacy\" value=\"1\" required>\r\n <span>\r\n J\u2019ai lu et j\u2019accepte la\r\n <a href=\"\/fr\/politique-de-confidentialite\/\" target=\"_blank\" rel=\"noopener\">politique de confidentialit\u00e9<\/a>\r\n de 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document.getElementById('case_code');\r\n const downloadLinks = document.querySelectorAll('.phinc-download');\r\n\r\n downloadLinks.forEach(a => {\r\n a.addEventListener('click', () => {\r\n const code = a.getAttribute('data-case') || '';\r\n const pdf = a.getAttribute('data-pdf') || '';\r\n if (select && code) select.value = code;\r\n if (pdfInput) pdfInput.value = pdf;\r\n if (caseInput) caseInput.value = code;\r\n });\r\n });\r\n })();\r\n <\/script>\r\n\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>", "protected": false }, "excerpt": { "rendered": "<p>Real projects, real impact \u2014 explore how PhinC’s modeling expertise has shaped drug development strategies across therapeutic areas and development stages.<\/p>", "protected": false }, "author": 2, "featured_media": 4548, "parent": 0, "menu_order": 0, "comment_status": "closed", "ping_status": "closed", "template": "", "meta": { "_acf_changed": false, "footnotes": "" }, "class_list": 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