{ "id": 3795, "date": "2026-01-27T15:19:14", "date_gmt": "2026-01-27T14:19:14", "guid": { "rendered": "https:\/\/www.phinc-group.com\/?page_id=3795" }, "modified": "2026-03-30T10:38:58", "modified_gmt": "2026-03-30T08:38:58", "slug": "fih", "status": "publish", "type": "page", "link": "https:\/\/www.phinc-group.com\/fr\/fih\/", "title": { "rendered": "1ere administration (FiH)" }, "content": { "rendered": "
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.cases{grid-template-columns:1fr;}\r\n }\r\n <\/style>\r\n\r\n <!-- SECTION 1 \u2014 HERO -->\r\n <div class=\"hero\">\r\n <div class=\"wrap section\">\r\n <div class=\"split\">\r\n <div>\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> First-in-Human \u2022 PBPK \u2022 Mod\u00e9lisation<\/span>\r\n <h2><br>Des d\u00e9cisions FIH plus s\u00fbres, <br>gr\u00e2ce \u00e0 la PBPK<\/h2>\r\n <p class=\"muted\">\r\n Dose de d\u00e9part, escalade, DDI, variabilit\u00e9 : nous transformons vos donn\u00e9es en recommandations claires et actionnables.\r\n <\/p>\r\n\r\n <div class=\"actions\">\r\n <a class=\"btn primary\" href=\"#contact\">\r\n Parler \u00e0 un expert\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n <a class=\"btn secondary\" href=\"#case-studies\">Voir les \u00e9tudes de cas<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n <!-- \u2705 Replace PBPK block with an image -->\r\n <div class=\"hero-card\" aria-label=\"Visuel First-in-Human\">\r\n <div class=\"hero-image\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/cover-fih-1000-x-670px.jpg\" alt=\"First-in-Human \u2013 PBPK & Mod\u00e9lisation\" loading=\"lazy\" \/>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <!-- SECTION 2 \u2014 PBPK + WHAT WE DO (merged) -->\r\n <div class=\"section\" id=\"pbpk\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> PBPK en FIH \u2022 Notre approche<\/span>\r\n <h2>Construisez une strat\u00e9gie FIH robuste gr\u00e2ce \u00e0 la PBPK<\/h2>\r\n <p class=\"muted\" style=\"max-width:880px;\">\r\n Une approche l\u00e9g\u00e8re et orient\u00e9e d\u00e9cision : simulations cibl\u00e9es, hypoth\u00e8ses explicites, livrables faciles \u00e0 int\u00e9grer.\r\n <\/p>\r\n\r\n <div class=\"feature-grid\">\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M4 19h16v2H4v-2zm2-6h2v5H6v-5zm5-8h2v13h-2V5zm5 4h2v9h-2V9z\"\/><\/svg>\r\n <\/div>\r\n <h3>Dose & escalade<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>D\u00e9finir une dose de d\u00e9part robuste (hypoth\u00e8ses + marges de s\u00e9curit\u00e9).<\/li>\r\n <li><span class=\"b-dot\"><\/span>Des simulations SAD\/MAD pour une escalade de dose plus s\u00fbre et plus efficace.<\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M12 2a7 7 0 017 7c0 2.1-.9 4-2.4 5.4l2.3 5.6h-2.2l-1.7-4.1c-.6.2-1.3.3-2 .3a7 7 0 110-14zm0 2a5 5 0 100 10 5 5 0 000-10z\"\/><\/svg>\r\n <\/div>\r\n <h3>DDI & variabilit\u00e9<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>Anticiper l\u2019impact d\u2019inhibiteurs\/inducteurs (CYP\/transporteurs) sur l\u2019exposition.<\/li>\r\n <li><span class=\"b-dot\"><\/span>Tester des sc\u00e9narios \u201cworst case\u201d et quantifier l\u2019incertitude.<\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M7 2h10v2H7V2zM5 6h14v16H5V6zm2 2v12h10V8H7z\"\/><\/svg>\r\n <\/div>\r\n <h3>Rapport pr\u00eat \u00e0 int\u00e9grer<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>R\u00e9sultats, figures et hypoth\u00e8ses structur\u00e9es pour protocole & dossier.<\/li>\r\n <li><span class=\"b-dot\"><\/span>Aligner clinique, non-clinique et r\u00e9glementaire autour de messages cl\u00e9s partag\u00e9s.<\/li>\r\n <\/ul>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <\/div>\r\n <\/div>\r\n\r\n <!-- SECTION 3 \u2014 CASE STUDIES (simple template) -->\r\n <div class=\"section\" id=\"case-studies\" style=\"background:var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line);\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> Case studies<\/span>\r\n\r\n <div class=\"cases\">\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Pharmacokinetic prediction using pre-clinical data to develop a PBPK model for FIH translation<\/h3>\r\n <p>Le sponsor a demand\u00e9 le d\u00e9veloppement d\u2019un mod\u00e8le PBPK complet int\u00e9grant les donn\u00e9es pr\u00e9cliniques, afin de construire un cadre PBPK pour la transposition FIH.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/#pbpk-case-studies\">Voir l'\u00e9tude de cas<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <!-- SECTION 4 \u2014 FINAL CTA (very light) -->\r\n <div class=\"cta-band section tight\" id=\"contact\">\r\n <div class=\"wrap\">\r\n <div class=\"cta-box\">\r\n <div>\r\n <h2>Une strat\u00e9gie FIH construite sur des bases quantitatives solides<\/h2>\r\n <p>Des recommandations simples, d\u00e9fendables, et centr\u00e9es sur votre prochaine d\u00e9cision.<\/p>\r\n <\/div>\r\n <div class=\"actions\" style=\"margin-top:50;\">\r\n <a class=\"btn primary\" href=\"\/fr\/contact\/\">\r\n Parler \u00e0 un expert\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n <a class=\"btn secondary\" href=\"\/fr\/case-studies\/#pbpk-case-studies\">\r\n Voir les \u00e9tudes de cas\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n \r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <script>\r\n 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