{
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    "date": "2025-08-13T15:22:46",
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    "modified": "2026-03-30T10:51:39",
    "modified_gmt": "2026-03-30T08:51:39",
    "slug": "clinical-trial-simulation",
    "status": "publish",
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    "link": "https:\/\/www.phinc-group.com\/fr\/clinical-trial-simulation\/",
    "title": {
        "rendered": "Simulation d’essais cliniques"
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    "content": {
        "rendered": "<div data-elementor-type=\"wp-page\" data-elementor-id=\"3270\" class=\"elementor elementor-3270\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-54045b4 e-con-full e-flex e-con e-parent\" data-id=\"54045b4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-bcff02c e-con-full e-flex e-con e-child\" data-id=\"bcff02c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-1a38d71 e-con-full e-flex e-con e-child\" data-id=\"1a38d71\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4a8fc04 elementor-widget elementor-widget-image\" data-id=\"4a8fc04\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1536\" height=\"1024\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Clinical-Trial-Simulation-1-1.png\" class=\"attachment-full size-full wp-image-3322\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Clinical-Trial-Simulation-1-1.png 1536w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Clinical-Trial-Simulation-1-1-300x200.png 300w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Clinical-Trial-Simulation-1-1-1024x683.png 1024w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Clinical-Trial-Simulation-1-1-768x512.png 768w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Clinical-Trial-Simulation-1-1-18x12.png 18w\" sizes=\"(max-width: 1536px) 100vw, 1536px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7980f89 e-con-full e-flex e-con e-child\" data-id=\"7980f89\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22dffc7 elementor-widget elementor-widget-heading\" data-id=\"22dffc7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">SOLUTIONS<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3cc2a98 elementor-widget elementor-widget-heading\" data-id=\"3cc2a98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pour une meilleure transposition de la conception de l\u2019\u00e9tude vers le succ\u00e8s de l\u2019essai.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3fee7ded elementor-widget elementor-widget-text-editor\" data-id=\"3fee7ded\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La simulation d\u2019essais cliniques (CTS \u2013 Clinical Trial Simulation) est une approche stochastique permettant de pr\u00e9dire les r\u00e9sultats des essais cliniques et la puissance statistique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6d324d elementor-align-left elementor-tablet-align-center elementor-widget elementor-widget-button\" data-id=\"d6d324d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm elementor-animation-grow\" href=\"\/fr\/contact\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Nous contacter !<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-deec8c8 elementor-absolute elementor-hidden-tablet elementor-hidden-mobile elementor-align-center elementor-widget elementor-widget-lottie\" data-id=\"deec8c8\" data-element_type=\"widget\" data-e-type=\"widget\" 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class=\"elementor-element elementor-element-679588dc elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-invisible elementor-widget elementor-widget-icon-box\" data-id=\"679588dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMod\u00e8les de la maladie\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\td\u00e9crivant l\u2019\u00e9volution naturelle de la pathologie.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div 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data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tMod\u00e8les d\u2019essais cliniques\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tint\u00e9grant les taux d\u2019abandon, l\u2019observance et les effets placebo\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9d69dfd e-con-full e-flex e-con e-child\" data-id=\"9d69dfd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-33b6400a elementor-view-framed elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"33b6400a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"a0416152-6e70-420c-a0f9-189edff1fe9e\" data-name=\"Layer 1\" width=\"148\" height=\"148\" viewbox=\"0 0 148 148\"><g style=\"opacity:0\"><rect width=\"148\" height=\"148\" style=\"fill:#fff\"><\/rect><\/g><path d=\"M126,74.0005c0-2.2373-1.375-4.4072-4.0869-6.4492a25.0508,25.0508,0,0,0-3.3946-2.12,25.0206,25.0206,0,0,0,3.3946-2.12C124.6252,61.27,126,59.1,126,56.8628s-1.375-4.4063-4.0869-6.4492A37.9014,37.9014,0,0,0,110.77,45.1475C100.949,42.0181,87.89,40.2944,74,40.2944S47.051,42.0181,37.23,45.1475a37.8986,37.8986,0,0,0-11.1435,5.2661C23.3748,52.4565,22,54.6265,22,56.8628s1.375,4.4072,4.0864,6.4492a25.0282,25.0282,0,0,0,3.3946,2.12,25.0364,25.0364,0,0,0-3.3941,2.12C23.3748,69.5933,22,71.7632,22,74.0005s1.375,4.4062,4.0869,6.4492a25.0858,25.0858,0,0,0,3.3949,2.1191,25.0958,25.0958,0,0,0-3.3949,2.1192C23.3748,86.73,22,88.9,22,91.1372s1.375,4.4072,4.0864,6.4492A37.9045,37.9045,0,0,0,37.23,102.853c9.8194,3.1289,22.878,4.8526,36.77,4.8526s26.9506-1.7237,36.77-4.8526a37.9012,37.9012,0,0,0,11.1435-5.2666C124.6252,95.5444,126,93.3745,126,91.1372s-1.375-4.4072-4.0869-6.4492a25.0824,25.0824,0,0,0-3.3944-2.1192,25.0724,25.0724,0,0,0,3.3944-2.1191C124.6252,78.4067,126,76.2368,126,74.0005ZM27.29,61.7144C25.1375,60.0933,24,58.416,24,56.8628s1.1377-3.23,3.29-4.8516a36.5208,36.5208,0,0,1,10.5478-4.9585C47.4675,43.9844,60.31,42.2944,74,42.2944s26.5327,1.69,36.1626,4.7583A36.5119,36.5119,0,0,1,120.71,52.0112c2.1523,1.6211,3.29,3.2989,3.29,4.8516s-1.1377,3.23-3.29,4.8516a25.6336,25.6336,0,0,1-4.4845,2.6189,54.0491,54.0491,0,0,0-5.4559-2.05c-9.8218-3.1289-22.88-4.8521-36.77-4.8521S47.052,59.1548,37.23,62.2837A53.98,53.98,0,0,0,31.774,64.333,25.6488,25.6488,0,0,1,27.29,61.7144Zm86.3685,3.7169q-1.6473.6477-3.4959,1.2411C100.5339,69.7417,87.6912,71.4312,74,71.4312s-26.5337-1.69-36.1622-4.7588q-1.8513-.59-3.4954-1.2411,1.6473-.6479,3.4954-1.2414C47.468,61.1216,60.3108,59.4312,74,59.4312s26.5322,1.69,36.1626,4.7587Q112.014,64.78,113.6583,65.4313ZM120.71,86.2856c2.1523,1.6211,3.29,3.2989,3.29,4.8516s-1.1377,3.23-3.29,4.8516a36.4867,36.4867,0,0,1-10.5478,4.958c-9.6285,3.0693-22.4712,4.7588-36.1626,4.7588s-26.5337-1.69-36.1622-4.7588A36.5,36.5,0,0,1,27.29,95.9888C25.1375,94.3677,24,92.69,24,91.1372s1.1377-3.2305,3.29-4.8516a25.68,25.68,0,0,1,4.4846-2.6187A54.0214,54.0214,0,0,0,37.23,85.7163C47.053,88.8452,60.1111,90.5688,74,90.5688s26.9472-1.7236,36.77-4.8525a54.009,54.009,0,0,0,5.456-2.0492A25.647,25.647,0,0,1,120.71,86.2856ZM34.3416,82.5688q1.6475-.6478,3.496-1.2412C47.469,78.2583,60.3118,76.5688,74,76.5688s26.5312,1.69,36.1626,4.7588q1.8512.59,3.4954,1.2412-1.6473.6478-3.4954,1.2413C100.531,86.8794,87.6882,88.5688,74,88.5688S47.469,86.8794,37.8376,83.81Q35.986,83.22,34.3416,82.5688Zm81.8842-1.0982a54.009,54.009,0,0,0-5.456-2.0492C100.947,76.2925,87.8884,74.5688,74,74.5688S47.053,76.2925,37.23,79.4214a54.0214,54.0214,0,0,0-5.4558,2.0494A25.68,25.68,0,0,1,27.29,78.8521C25.1375,77.23,24,75.5522,24,74.0005s1.1377-3.2305,3.29-4.8516A25.6569,25.6569,0,0,1,31.7746,66.53,54.1044,54.1044,0,0,0,37.23,68.5786C47.05,71.7075,60.1082,73.4312,74,73.4312s26.9506-1.7237,36.77-4.8526a54.0674,54.0674,0,0,0,5.4559-2.0491,25.6343,25.6343,0,0,1,4.4845,2.6194c2.1523,1.6211,3.29,3.2989,3.29,4.8516s-1.1377,3.23-3.29,4.8516A25.647,25.647,0,0,1,116.2258,81.4706Z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b6748b elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-invisible elementor-widget elementor-widget-icon-box\" data-id=\"5b6748b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tDistribution des covariables\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tau sein de la population cible de patients\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a3befdd e-flex e-con-boxed e-con e-parent\" data-id=\"a3befdd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e0ac44d elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"e0ac44d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1998e735 elementor-widget elementor-widget-icon-box\" data-id=\"1998e735\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tLa mise en relation de l\u2019ensemble de ces informations au sein d\u2019un mod\u00e8le unique est rendue possible gr\u00e2ce \u00e0 l\u2019analyse CTS. Celle-ci permet de mieux comprendre la variabilit\u00e9 des r\u00e9sultats d\u2019un essai et d\u2019optimiser la strat\u00e9gie clinique.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-729a418 e-flex e-con-boxed e-con e-parent\" data-id=\"729a418\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4814b13 e-con-full e-flex e-con e-child\" data-id=\"4814b13\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9718cb7 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"9718cb7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49ba3ad6 elementor-widget elementor-widget-heading\" data-id=\"49ba3ad6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Conception des \u00e9tudes et succ\u00e8s op\u00e9rationnel dans le d\u00e9veloppement du m\u00e9dicament<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ff588f elementor-position-inline-start elementor-view-default elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"8ff588f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon elementor-animation-grow\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"a\" width=\"118\" height=\"91.6987\" viewbox=\"0 0 118 91.6987\"><path d=\"M113.3633,41.3608c-2.9707-2.2432-7.2246-4.2578-12.6445-5.9878-.5542-.1769-1.1243-.3469-1.6963-.5159C94.5818,14.8683,78.3264,0,59,0S23.4176,14.8683,18.9771,34.8572c-.572,.169-1.1421,.3389-1.6963,.5158-5.4175,1.7295-9.6719,3.7441-12.6445,5.9873-3.0762,2.3228-4.6362,4.7896-4.6362,7.3325s1.5601,5.0098,4.6362,7.332c2.9727,2.2441,7.2271,4.2588,12.6445,5.9873,1.1295,.3607,2.3062,.7005,3.5083,1.028,6.1289,16.7862,20.9424,28.6586,38.2109,28.6586s32.0811-11.8719,38.2101-28.6577c1.2023-.3275,2.379-.6672,3.5086-1.0278,5.4199-1.7305,9.6738-3.7451,12.6445-5.9883,3.0771-2.3223,4.6367-4.7891,4.6367-7.332s-1.5596-5.0098-4.6367-7.332ZM59,2c18.0346,0,33.2559,13.6783,37.8219,32.2381-10.5937-2.8356-23.8333-4.3826-37.8219-4.3826s-27.228,1.5471-37.8223,4.3827C25.7437,15.6783,40.9654,2,59,2Zm39.2285,43.8496c0,5.4691-.908,10.7033-2.5519,15.5357-10.3173,2.6849-23.1327,4.1454-36.6766,4.1454s-26.3595-1.4606-36.6771-4.1457c-1.6438-4.8323-2.5519-10.0665-2.5519-15.5355,0-3.2278,.3227-6.3714,.9177-9.4024,10.5837-2.9673,24.0403-4.5917,38.3113-4.5917s27.7272,1.6245,38.3108,4.5915c.595,3.0311,.9177,6.1748,.9177,9.4026ZM17.8892,60.1079c-5.1289-1.6377-9.2949-3.6016-12.0479-5.6787-2.5488-1.9248-3.8413-3.8545-3.8413-5.7363s1.2925-3.812,3.8413-5.7358c2.7529-2.0776,6.9189-4.0415,12.0479-5.6787,.2112-.0674,.4328-.1304,.6467-.1967-.4966,2.8397-.7649,5.7691-.7649,8.7679,0,5.2175,.7986,10.2285,2.2487,14.9051-.7242-.2093-1.4351-.4247-2.1306-.6468Zm41.1108,29.5908c-15.9609,0-29.7163-10.7159-35.8361-26.0441,10.2418,2.5116,22.7073,3.8761,35.8361,3.8761s25.5946-1.3644,35.8354-3.8754c-6.1198,15.3278-19.8748,26.0433-35.8354,26.0433Zm53.1582-35.2695c-2.751,2.0771-6.916,4.04-12.0469,5.6787-.6958,.2222-1.407,.4377-2.1316,.6471,1.4501-4.6766,2.2488-9.6878,2.2488-14.9054,0-2.999-.2682-5.9285-.765-8.7682,.2143,.0664,.4362,.1294,.6478,.197,5.1309,1.6377,9.2959,3.6016,12.0469,5.6787,2.5488,1.9243,3.8418,3.854,3.8418,5.7358s-1.293,3.8115-3.8418,5.7363Z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tL\u2019optimisation de la conception des \u00e9tudes et des param\u00e8tres op\u00e9rationnels est cruciale dans le d\u00e9veloppement du m\u00e9dicament. Ces \u00e9l\u00e9ments d\u00e9terminent la puissance statistique de l\u2019\u00e9tude, les crit\u00e8res de recrutement des patients, la mesure des crit\u00e8res d\u2019\u00e9valuation et, in fine, le succ\u00e8s ou l\u2019\u00e9chec de l\u2019essai.<br><br>\n\nLa mod\u00e9lisation et la simulation, en particulier via les approches CTS, permettent de pr\u00e9dire ces sc\u00e9narios en tenant compte de la variabilit\u00e9 de la r\u00e9ponse au traitement, de la progression de la maladie et du comportement des patients (notamment l\u2019observance). Ces outils facilitent l\u2019optimisation des protocoles et l\u2019\u00e9valuation des risques, tout en r\u00e9duisant la probabilit\u00e9 d\u2019essais non concluants ou infructueux, rationalisant ainsi le d\u00e9veloppement du m\u00e9dicament et augmentant les chances d\u2019approbation r\u00e9glementaire.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22282eb elementor-widget elementor-widget-text-editor\" data-id=\"22282eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Votre entreprise dispose d\u00e9j\u00e0 de donn\u00e9es issues des \u00e9tudes pr\u00e9cliniques et des phases I\/II ; votre candidat m\u00e9dicament a d\u00e9montr\u00e9 une preuve de concept ; vous avez \u00e9tudi\u00e9 les relations dose-r\u00e9ponse chez les patients. Ces r\u00e9sultats permettent d\u2019aller plus loin et d\u2019initier des \u00e9tudes pivots de phase III.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-62ffff9d e-con-full e-flex e-con e-child\" data-id=\"62ffff9d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429df572 elementor-widget-mobile__width-initial elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-invisible elementor-widget elementor-widget-image\" data-id=\"429df572\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"504\" height=\"762\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img2.png\" class=\"attachment-large size-large wp-image-3289\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img2.png 504w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img2-198x300.png 198w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img2-8x12.png 8w\" sizes=\"(max-width: 504px) 100vw, 504px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31461ff7 elementor-widget-mobile__width-initial elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-invisible elementor-widget elementor-widget-image\" data-id=\"31461ff7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"507\" height=\"762\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img3.png\" class=\"attachment-large size-large wp-image-3290\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img3.png 507w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img3-200x300.png 200w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img3-8x12.png 8w\" sizes=\"(max-width: 507px) 100vw, 507px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-716eec9d elementor-widget-mobile__width-initial elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-invisible elementor-widget elementor-widget-image\" data-id=\"716eec9d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"508\" height=\"762\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img4.png\" class=\"attachment-large size-large wp-image-3291\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img4.png 508w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img4-200x300.png 200w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img4-8x12.png 8w\" sizes=\"(max-width: 508px) 100vw, 508px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4976edb3 elementor-widget-mobile__width-initial elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-invisible elementor-widget elementor-widget-image\" data-id=\"4976edb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_delay&quot;:&quot;200&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"505\" height=\"762\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img1.png\" class=\"attachment-large size-large wp-image-3288\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img1.png 505w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img1-199x300.png 199w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/CTS-img1-8x12.png 8w\" sizes=\"(max-width: 505px) 100vw, 505px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7eee63b e-flex e-con-boxed e-con e-parent\" data-id=\"7eee63b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-06598c3 elementor-widget elementor-widget-icon-box\" data-id=\"06598c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tL\u2019approche CTS permet d\u2019\u00e9valuer in silico diff\u00e9rents sch\u00e9mas d\u2019essais et plans d\u2019analyses statistiques qui seront ensuite test\u00e9s dans les essais cliniques confirmatoires.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d738daf elementor-widget elementor-widget-heading\" data-id=\"d738daf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">En compl\u00e9ment, le CTS permet \u00e9galement de :<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7080c56 e-flex e-con-boxed e-con e-parent\" data-id=\"7080c56\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-02611e3 e-con-full e-flex e-con e-child\" data-id=\"02611e3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-16eefc0 elementor-view-framed elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"16eefc0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"a6e4e448-62eb-4a20-8ade-ac923322afab\" data-name=\"Layer 1\" width=\"148\" height=\"148\" viewbox=\"0 0 148 148\"><g style=\"opacity:0\"><rect width=\"148\" height=\"148\" style=\"fill:#fff\"><\/rect><\/g><path 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class=\"elementor-element elementor-element-68022ef elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-invisible elementor-widget elementor-widget-icon-box\" data-id=\"68022ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\t\u00c9valuer\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tla puissance statistique attendue selon diff\u00e9rents sc\u00e9narios.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-56ddc85 e-con-full e-flex e-con e-child\" data-id=\"56ddc85\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93d5175 elementor-view-framed elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"93d5175\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"fda62741-ee22-4fe4-b122-bd6f2b92a880\" data-name=\"Layer 1\" width=\"148\" height=\"148\" viewbox=\"0 0 148 148\"><g style=\"opacity:0\"><rect width=\"148\" height=\"148\" style=\"fill:#fff\"><\/rect><\/g><path 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d=\"M100.8,53.6a15.4425,15.4425,0,0,1,.8,4.4,15.4425,15.4425,0,0,1,.8-4.4,11.0373,11.0373,0,0,1,6.8-7.3,14.3667,14.3667,0,0,1,4.9-.8,14.3667,14.3667,0,0,1-4.9-.8,11.4627,11.4627,0,0,1-6.8-7.3,15.4425,15.4425,0,0,1-.8-4.4,15.4425,15.4425,0,0,1-.8,4.4A11.0373,11.0373,0,0,1,94,44.7a14.3667,14.3667,0,0,1-4.9.8,14.3667,14.3667,0,0,1,4.9.8A11.4627,11.4627,0,0,1,100.8,53.6Zm-3.6-8.7a13.6246,13.6246,0,0,0,4.2-4.9c.1-.2.1-.3.2-.5.1.1.1.3.2.5a11.4363,11.4363,0,0,0,4.2,4.9c.4.2.8.5,1.2.7a7.4586,7.4586,0,0,0-1.2.7,13.6246,13.6246,0,0,0-4.2,4.9c-.1.2-.1.3-.2.5,0-.2-.1-.3-.2-.5a11.4363,11.4363,0,0,0-4.2-4.9c-.4-.2-.8-.5-1.2-.7A7.4586,7.4586,0,0,0,97.2,44.9Z\" style=\"fill-rule:evenodd\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f137eb elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-invisible elementor-widget elementor-widget-icon-box\" data-id=\"9f137eb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tD\u00e9terminer\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tdes crit\u00e8res d\u2019inclusion\/exclusion optimaux afin d\u2019enrichir la population d\u2019\u00e9tude.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a321875 e-con-full e-flex e-con e-child\" data-id=\"a321875\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-196e0a4 elementor-view-framed elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"196e0a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" id=\"a0416152-6e70-420c-a0f9-189edff1fe9e\" data-name=\"Layer 1\" width=\"148\" height=\"148\" viewbox=\"0 0 148 148\"><g style=\"opacity:0\"><rect width=\"148\" height=\"148\" style=\"fill:#fff\"><\/rect><\/g><path 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class=\"elementor-element elementor-element-2ec6992 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-invisible elementor-widget elementor-widget-icon-box\" data-id=\"2ec6992\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tSoutenir\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tle rationnel des calculs de taille d\u2019\u00e9chantillon et des sch\u00e9mas d\u2019\u00e9chantillonnage.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-33849e9 e-flex e-con-boxed e-con e-parent\" data-id=\"33849e9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e055897 e-con-full e-flex e-con e-child\" data-id=\"e055897\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e59c0d8 elementor-widget elementor-widget-image\" data-id=\"e59c0d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1536\" height=\"1024\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Modeling-CTS.png\" class=\"attachment-full size-full wp-image-3299\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Modeling-CTS.png 1536w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Modeling-CTS-300x200.png 300w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Modeling-CTS-1024x683.png 1024w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Modeling-CTS-768x512.png 768w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/Modeling-CTS-18x12.png 18w\" sizes=\"(max-width: 1536px) 100vw, 1536px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-754de37 e-con-full e-flex e-con e-child\" data-id=\"754de37\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a5dbe78 elementor-widget elementor-widget-heading\" data-id=\"a5dbe78\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Transformer la simulation clinique en avantage strat\u00e9gique<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d112adf elementor-widget elementor-widget-text-editor\" data-id=\"d112adf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>PhinC Development excelle dans l\u2019utilisation de plateformes CTS avanc\u00e9es telles que MonolixSuite\u00ae et les logiciels SAS\u00ae.<\/p><p>Depuis de nombreuses ann\u00e9es, nous avons renforc\u00e9 notre expertise sur ces outils et \u00e9tabli un partenariat solide avec <strong data-start=\"2959\" 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contacter !<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>",
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