DDI \u2014 Apport de la mod\u00e9lisation | PhinC<\/title>\r\n <style>\r\n :root{\r\n --phinc-navy:#00005f;\r\n --phinc-pink:#f947ac;\r\n --bg:#fbfafc; \/* blanc cass\u00e9 *\/\r\n --card:#ffffff;\r\n --text:#0b0b1a;\r\n --muted:#4a4a68;\r\n --border:rgba(0,0,95,.12);\r\n --shadow:0 14px 40px rgba(0,0,95,.10);\r\n --radius:18px;\r\n --radius-lg:26px;\r\n --max:1120px;\r\n --line:rgba(0,0,95,.12); \/* compat case studies *\/\r\n }\r\n\r\n *{box-sizing:border-box}\r\n html,body{height:100%}\r\n body{\r\n margin:0;\r\n font-family: ui-sans-serif, system-ui, -apple-system, Segoe UI, Roboto, Helvetica, Arial, \"Apple Color Emoji\",\"Segoe UI Emoji\";\r\n color:var(--text);\r\n background:\r\n radial-gradient(1000px 700px at 15% 0%, rgba(249,71,172,.10), transparent 60%),\r\n radial-gradient(900px 600px at 85% 10%, rgba(0,0,95,.12), transparent 55%),\r\n var(--bg);\r\n line-height:1.5;\r\n }\r\n\r\n a{color:inherit}\r\n .wrap{max-width:var(--max); margin:0 auto; padding:0 20px;}\r\n\r\n \/* Buttons *\/\r\n .btnRow{display:flex; 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align-items:center; gap:10px;\r\n color:var(--phinc-navy);\r\n font-weight:800;\r\n font-size:12px;\r\n letter-spacing:.18em;\r\n text-transform:uppercase;\r\n }\r\n .eyebrow .dot{\r\n margin-top:0;\r\n width:12px; height:12px;\r\n border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-pink), var(--phinc-navy));\r\n }\r\n\r\n .cases{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:18px;\r\n }\r\n .case{\r\n border-radius:18px;\r\n border:1px solid var(--border);\r\n background:var(--card);\r\n box-shadow:0 10px 26px rgba(0,0,95,.08);\r\n overflow:hidden;\r\n display:flex;\r\n flex-direction:column;\r\n min-height:100%;\r\n }\r\n .case .thumb{\r\n width:100%;\r\n aspect-ratio: 3 \/ 2;\r\n background:rgba(0,0,95,.03);\r\n overflow:hidden;\r\n }\r\n .case .thumb img{\r\n width:100%;\r\n height:100%;\r\n object-fit:cover;\r\n display:block;\r\n transition:transform .18s ease;\r\n }\r\n .case:hover .thumb img{transform:scale(1.02);}\r\n .case .content{padding:16px 16px 0;}\r\n .case .content h3{\r\n margin:0 0 6px;\r\n font-size:16px;\r\n color:var(--phinc-navy);\r\n }\r\n .case .content p{font-size:14px; color:var(--muted);}\r\n .case .cta{padding:14px 16px 16px; margin-top:auto;}\r\n\r\n \/* Contact *\/\r\n .contactShell{\r\n padding:26px;\r\n border-radius:var(--radius-lg);\r\n background:\r\n radial-gradient(1000px 600px at 10% 10%, rgba(249,71,172,.10), transparent 55%),\r\n radial-gradient(900px 520px at 90% 20%, rgba(0,0,95,.10), transparent 55%),\r\n var(--card);\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .heroGrid{grid-template-columns:1fr;}\r\n .heroRight{min-height:260px;}\r\n .threeCols{grid-template-columns:1fr;}\r\n .cases{grid-template-columns:1fr;}\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n\r\n \r\n <main id=\"top\">\r\n <section class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"heroGrid\">\r\n \r\n <div class=\"heroLeft\">\r\n <div class=\"kicker\">DDI<\/div>\r\n <h2>Anticipate, quantify, and explain interaction risk \u2014 before the trial.<\/h2>\r\n <p class=\"lead\">\r\n Modeling & simulation (PK\/PD, PBPK, popPK) help you prioritize DDI studies, justify clinical scenarios, and secure recommendations (labeling, dose adjustments, contraindications).\r\n <\/p>\r\n\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/en\/contact\/\">Get in touch<\/a>\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case studies<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <figure class=\"heroRight\" aria-label=\"Visuel DDI\">\r\n <img decoding=\"async\"\r\n class=\"heroImg\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/DDI-cover-1000-x-670px.jpg\"\r\n alt=\"DDI \u2014 visuel\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/figure>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"applications-ddi\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Applications<\/div>\r\n <h2>Applications of modeling: which approaches for DDIs<\/h2>\r\n <p>Data-driven analyses to prioritize studies and support clear recommendations.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cperpetrator\u201d (inhibition\/induction)<\/h3>\r\n <p>Predict the impact on substrate exposure (AUC, Cmax), frame scenarios, and define the need for clinical studies.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cvictim\u201d (candidate sensitivity)<\/h3>\r\n <p>Quantify sensitivity to inhibitors\/inducers, identify worst-case scenarios, and pinpoint critical co-medications.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Recommandations & label<\/h3>\r\n <p>Translate results into defensible recommendations: dose adjustments, dosing windows, contraindications.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>PBPK & \u201cwhat-if\u201d scenarios<\/h3>\r\n <p>Explore enzymes\/transporters, polymorphisms, organ impairment, multiple perpetrators, and extrapolations.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>PopPK \/ integrated modeling<\/h3>\r\n <p>Leverage clinical data (sparse\/dense), covariates, real-world co-medications, and interindividual variability.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Study design & prioritization<\/h3>\r\n <p>Selection of substrates\/inhibitors\/inducers, doses, dosing windows, washout, and power \u2014 for an efficient DDI plan.<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"expertise\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">PhinC Expertise<\/div>\r\n <h2>A DDI strategy aligned with data, mechanisms, and regulatory expectations<\/h2>\r\n <p>From rapid triage to a full PBPK model \u2014 with deliverables ready for clinical and regulatory use.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>Mechanistic interpretation<\/h3>\r\n <p>Enzyme\/transporter hypotheses, in vitro\/in vivo parameters, uncertainties, and a model qualification plan.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Scientific evidence strategy<\/h3>\r\n <p>What level of evidence is needed for each decision: extrapolation, dedicated study, or opportunistic analysis.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Submission-ready deliverables<\/h3>\r\n <p>Reports, appendices, and justification materials to support agency interactions and regulatory dossiers (protocols, SAPs, CSRs).<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <div class=\"section\" id=\"case-studies\" style=\"background:var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line);\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> Case studies<\/span>\r\n\r\n <div class=\"cases\">\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #1<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #2<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #3<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <section id=\"contact\">\r\n <div class=\"wrap\">\r\n <div class=\"contactShell\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Get in touch<\/div>\r\n <h2>Share your DDI context: mechanism, data, and the decision to be secured<\/h2>\r\n <p>We get back to you with a clear strategy, defined timelines, and tailored deliverables (triage \u2192 model \u2192 recommendations).<\/p>\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/en\/contact\/\">Book a call with an expert<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <\/main>\r\n\r\n <script>\r\n const y = document.getElementById('year');\r\n if (y) y.textContent = new Date().getFullYear();\r\n <\/script>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"domaine":[],"class_list":["post-2413","service","type-service","status-publish","hentry"],"acf":[],"yoast_head":"\n<title>Interactions m\u00e9dicamenteuses (DDI) - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/service\/ddi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/en\/service\/ddi\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC Group\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-13T15:00:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/\",\"url\":\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/\",\"name\":\"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.phinc-group.com\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/case-studies-cover-600x400-1.jpg\",\"datePublished\":\"2025-04-10T11:47:52+00:00\",\"dateModified\":\"2026-02-13T15:00:46+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.phinc-group.com\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/case-studies-cover-600x400-1.jpg\",\"contentUrl\":\"https:\\\/\\\/www.phinc-group.com\\\/wp-content\\\/uploads\\\/2026\\\/02\\\/case-studies-cover-600x400-1.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/service\\\/ddi\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/www.phinc-group.com\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Interactions m\u00e9dicamenteuses (DDI)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/\",\"name\":\"PhinC Group\",\"description\":\"Quantitative Pharmacology Solutions & Modeling\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/#organization\",\"name\":\"PhinC Group\",\"url\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.phinc-group.com\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/Icone-PhinC-New_white-600px.jpg\",\"contentUrl\":\"https:\\\/\\\/www.phinc-group.com\\\/wp-content\\\/uploads\\\/2025\\\/01\\\/Icone-PhinC-New_white-600px.jpg\",\"width\":600,\"height\":600,\"caption\":\"PhinC Group\"},\"image\":{\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n","yoast_head_json":{"title":"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.phinc-group.com\/en\/service\/ddi\/","og_locale":"en_US","og_type":"article","og_title":"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group","og_description":"DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). 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align-items:center; gap:10px;\r\n color:var(--phinc-navy);\r\n font-weight:800;\r\n font-size:12px;\r\n letter-spacing:.18em;\r\n text-transform:uppercase;\r\n }\r\n .eyebrow .dot{\r\n margin-top:0;\r\n width:12px; height:12px;\r\n border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-pink), var(--phinc-navy));\r\n }\r\n\r\n .cases{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:18px;\r\n }\r\n .case{\r\n border-radius:18px;\r\n border:1px solid var(--border);\r\n background:var(--card);\r\n box-shadow:0 10px 26px rgba(0,0,95,.08);\r\n overflow:hidden;\r\n display:flex;\r\n flex-direction:column;\r\n min-height:100%;\r\n }\r\n .case .thumb{\r\n width:100%;\r\n aspect-ratio: 3 \/ 2;\r\n background:rgba(0,0,95,.03);\r\n overflow:hidden;\r\n }\r\n .case .thumb img{\r\n width:100%;\r\n height:100%;\r\n object-fit:cover;\r\n display:block;\r\n transition:transform .18s ease;\r\n }\r\n .case:hover .thumb img{transform:scale(1.02);}\r\n .case .content{padding:16px 16px 0;}\r\n .case .content h3{\r\n margin:0 0 6px;\r\n font-size:16px;\r\n color:var(--phinc-navy);\r\n }\r\n .case .content p{font-size:14px; color:var(--muted);}\r\n .case .cta{padding:14px 16px 16px; margin-top:auto;}\r\n\r\n \/* Contact *\/\r\n .contactShell{\r\n padding:26px;\r\n border-radius:var(--radius-lg);\r\n background:\r\n radial-gradient(1000px 600px at 10% 10%, rgba(249,71,172,.10), transparent 55%),\r\n radial-gradient(900px 520px at 90% 20%, rgba(0,0,95,.10), transparent 55%),\r\n var(--card);\r\n border:1px solid var(--border);\r\n box-shadow:var(--shadow);\r\n }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .heroGrid{grid-template-columns:1fr;}\r\n .heroRight{min-height:260px;}\r\n .threeCols{grid-template-columns:1fr;}\r\n .cases{grid-template-columns:1fr;}\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n\r\n \r\n <main id=\"top\">\r\n <section class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"heroGrid\">\r\n \r\n <div class=\"heroLeft\">\r\n <div class=\"kicker\">DDI<\/div>\r\n <h2>Anticipate, quantify, and explain interaction risk \u2014 before the trial.<\/h2>\r\n <p class=\"lead\">\r\n Modeling & simulation (PK\/PD, PBPK, popPK) help you prioritize DDI studies, justify clinical scenarios, and secure recommendations (labeling, dose adjustments, contraindications).\r\n <\/p>\r\n\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/en\/contact\/\">Get in touch<\/a>\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case studies<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <figure class=\"heroRight\" aria-label=\"Visuel DDI\">\r\n <img decoding=\"async\"\r\n class=\"heroImg\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/DDI-cover-1000-x-670px.jpg\"\r\n alt=\"DDI \u2014 visuel\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/figure>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"applications-ddi\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Applications<\/div>\r\n <h2>Applications of modeling: which approaches for DDIs<\/h2>\r\n <p>Data-driven analyses to prioritize studies and support clear recommendations.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cperpetrator\u201d (inhibition\/induction)<\/h3>\r\n <p>Predict the impact on substrate exposure (AUC, Cmax), frame scenarios, and define the need for clinical studies.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>DDI \u201cvictim\u201d (candidate sensitivity)<\/h3>\r\n <p>Quantify sensitivity to inhibitors\/inducers, identify worst-case scenarios, and pinpoint critical co-medications.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Recommandations & label<\/h3>\r\n <p>Translate results into defensible recommendations: dose adjustments, dosing windows, contraindications.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>PBPK & \u201cwhat-if\u201d scenarios<\/h3>\r\n <p>Explore enzymes\/transporters, polymorphisms, organ impairment, multiple perpetrators, and extrapolations.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>PopPK \/ integrated modeling<\/h3>\r\n <p>Leverage clinical data (sparse\/dense), covariates, real-world co-medications, and interindividual variability.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Study design & prioritization<\/h3>\r\n <p>Selection of substrates\/inhibitors\/inducers, doses, dosing windows, washout, and power \u2014 for an efficient DDI plan.<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <section id=\"expertise\">\r\n <div class=\"wrap\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">PhinC Expertise<\/div>\r\n <h2>A DDI strategy aligned with data, mechanisms, and regulatory expectations<\/h2>\r\n <p>From rapid triage to a full PBPK model \u2014 with deliverables ready for clinical and regulatory use.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"threeCols\">\r\n <div class=\"feature card\">\r\n <h3>Mechanistic interpretation<\/h3>\r\n <p>Enzyme\/transporter hypotheses, in vitro\/in vivo parameters, uncertainties, and a model qualification plan.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Scientific evidence strategy<\/h3>\r\n <p>What level of evidence is needed for each decision: extrapolation, dedicated study, or opportunistic analysis.<\/p>\r\n <\/div>\r\n <div class=\"feature card\">\r\n <h3>Submission-ready deliverables<\/h3>\r\n <p>Reports, appendices, and justification materials to support agency interactions and regulatory dossiers (protocols, SAPs, CSRs).<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n \r\n <div class=\"section\" id=\"case-studies\" style=\"background:var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line);\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> Case studies<\/span>\r\n\r\n <div class=\"cases\">\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #1<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #2<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Case study #3<\/h3>\r\n <p>Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <section id=\"contact\">\r\n <div class=\"wrap\">\r\n <div class=\"contactShell\">\r\n <div class=\"sectionHead\">\r\n <div>\r\n <div class=\"kicker\">Get in touch<\/div>\r\n <h2>Share your DDI context: mechanism, data, and the decision to be secured<\/h2>\r\n <p>We get back to you with a clear strategy, defined timelines, and tailored deliverables (triage \u2192 model \u2192 recommendations).<\/p>\r\n <div class=\"btnRow\">\r\n <a class=\"btn primary\" href=\"\/en\/contact\/\">Book a call with an expert<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <\/main>\r\n\r\n <script>\r\n const y = document.getElementById('year');\r\n if (y) y.textContent = new Date().getFullYear();\r\n <\/script>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). Planifier un \u00e9change Voir les \u00e9tudes de cas Applications Applications de […]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"domaine":[],"class_list":["post-2413","service","type-service","status-publish","hentry"],"acf":[],"yoast_head":"\n<title>Interactions m\u00e9dicamenteuses (DDI) - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/service\/ddi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Interactions m\u00e9dicamenteuses (DDI) - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"DDI \u2014 Apport de la mod\u00e9lisation | PhinC DDI Anticipez, quantifiez et expliquez le risque d\u2019interactions \u2014 avant l\u2019essai. La mod\u00e9lisation & simulation (PK\/PD, PBPK, popPK) vous aide \u00e0 prioriser les \u00e9tudes DDI, justifier les sc\u00e9narios cliniques et s\u00e9curiser les recommandations (\u00e9tiquetage, ajustements, contre-indications). 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