PhinC \u2013 PBPK & PBBM (Aper\u00e7u)<\/title>\r\n<\/head>\r\n\r\n<body style=\"margin:0;background:#ffffff;\">\r\n<section class=\"phinc-pbpkpbbm\">\r\n <style>\r\n :root{\r\n --phinc-blue:#00005f;\r\n --phinc-pink:#D94B9F;\r\n --ink:#0F172A;\r\n --muted:#475569;\r\n --line:#E6EAF2;\r\n --bg:#F7F9FC; \/* gris clair *\/\r\n --card:#FFFFFF; \/* blanc *\/\r\n --radius:18px;\r\n --shadow: 0 10px 30px rgba(15, 23, 42, .08);\r\n --max:1120px;\r\n }\r\n\r\n .phinc-pbpkpbbm{\r\n font-family: inherit; \/* Inter via Elementor *\/\r\n color:var(--ink);\r\n }\r\n\r\n .phinc-wrap{\r\n max-width:var(--max);\r\n margin:0 auto;\r\n padding:6px 78px;\r\n }\r\n\r\n \/* \u2705 Alternance de fond par section *\/\r\n .phinc-sec{ padding:56px 0; }\r\n .phinc-sec.is-white{ background:#fff; }\r\n .phinc-sec.is-gray{ background:var(--bg); }\r\n\r\n \/* \u2705 S\u00e9parateur fin full-width entre sections *\/\r\n .phinc-sep{\r\n height:1px;\r\n width:100%;\r\n background:var(--line);\r\n margin:0;\r\n 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p{\r\n margin:0;\r\n color:var(--muted);\r\n font-size:14.5px;\r\n line-height:1.6;\r\n max-width:92ch;\r\n }\r\n .cta-final .cta-row{ margin-top:16px; }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .hero-grid{ grid-template-columns:1fr; }\r\n .grid-3{ grid-template-columns:1fr; }\r\n .grid-2{ grid-template-columns:1fr; }\r\n ul.clean.clean--4col{ grid-template-columns: repeat(2, 1fr); }\r\n .card--full{ grid-column:auto; }\r\n .phinc-wrap{ padding:44px 18px; }\r\n }\r\n @media (max-width: 560px){\r\n ul.clean.clean--4col{ grid-template-columns: 1fr; }\r\n }\r\n <\/style>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"hero\">\r\n <div class=\"hero-grid\">\r\n <div>\r\n <div class=\"kicker\">PBPK & PBBM \u2022 Mechanistic Modeling<\/div>\r\n <h2 style=\"margin-top:14px;\">From non-clinical data and formulation design to First-in-Human<\/h2>\r\n <p class=\"subhead translation-block\">PhinC supports development teams with <b>PBPK<\/b> and <b>PBBM<\/b> strategies to anticipate exposure, optimize doses,\n\nsecure key decisions and strengthen regulatory dossiers.<\/p>\r\n\r\n <div class=\"cta-row\">\r\n \r\n<a class=\"btn phinc-btn primary\" href=\"\/en\/case-studies\/#pbpk-case-studies\">\r\n See case studies\r\n \r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-media\" aria-label=\"Cover Phase 1\">\r\n <img decoding=\"async\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/cover-pbpk-800x533-1.jpg\"\r\n alt=\"Couverture Phase 1\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Physiology-based pharmacokinetic modeling (PBPK)<\/h2>\r\n <p class=\"lead\">For better translation from non-clinical to human.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Explaining PBPK<\/div>\r\n <h3>A robust mechanistic ADME model<\/h3>\r\n <p class=\"translation-block\">PBPK modeling predicts <b>absorption, distribution, metabolism, and excretion<\/b> by integrating molecule-specific properties and physiological system knowledge within a unified quantitative framework.<\/p>\r\n\r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Anatomy and physiology<\/b><span>Representation of the human or animal body.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Physicochemical properties<\/b><span>Parameters influencing distribution and permeability.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>In vitro Biotransformation<\/b><span>Enzymes, metabolic pathways, intrinsic clearance.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Transportation process<\/b><span>Active\/passive transport across tissues.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Why is it essential<\/div>\r\n <h3>Derisking early clinical development<\/h3>\r\n <p>\r\n PBPK supports dose and dosing regimen selection by explicitly considering physiology,\n\nin vitro metabolism\/transport and inter-individual variability \u2014 reducing the need for extensive in vivo studies and accelerating turnaround times.\r\n <\/p>\r\n<br><br>\r\n \r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> When to use PBPK<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>First-in-Human (FIH)<\/b><span>Testing dose scenarios in silico before clinical execution.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Drug-Drug Interactions (DDI)<\/b><span>Estimate the extent of the interactions and support the mitigation strategy.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Special populations<\/b><span>Pediatrics, liver or kidney failure, and other situations.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Food & bridging<\/b><span>Food effect, change in formulation, justification for bridging.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Data often available<\/div>\r\n <h3>Datasets that can be used quickly<\/h3>\r\n <p>Preclinical PK, animal studies, and in vitro metabolism and transport data provide a solid basis for starting a PBPK analysis.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Delivrables<\/div>\r\n <h3>Clear, submission-ready outputs.<\/h3>\r\n <p>Simulation reports, scenario comparisons, sensitivity analyses, full traceability of assumptions, and decision-oriented recommendations.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Platform<\/div>\r\n <h3>GastroPlus\u00ae Expertise<\/h3>\r\n <p>PhinC pioneered the use of GastroPlus\u00ae and maintains a strong partnership with Simulations Plus\u00ae to deploy best-practice PBPK workflows.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Physiology-based biopharmaceutical modeling (PBBM)<\/h2>\r\n <p class=\"lead\">For a better translation from formulation design to in vivo performance<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Explaining PBBM<\/div>\r\n <h3>Mechanistic modeling of absorption and bioavailability<\/h3>\r\n <p class=\"translation-block\">PBBM predicts <b>absorption and bioavailability<\/b> by integrating formulation characteristics with gastrointestinal physiology,\n\nallowing a quantitative link between <b>in vitro<\/b> observations and <b>in vivo<\/b> performance.<\/p>\r\n\r\n \r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Physicochemical properties<\/b><span>Solubility, permeability, stability (pKa, LogP).<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Formulation models<\/b><span>Dissolution, particle size, release.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Gastrointestinal physiology<\/b><span>pH, transit, first-pass effect, bile.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Variability<\/b><span>Age, GI conditions, patient subgroups.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Why is it essential<\/div>\r\n <h3>Optimize formulation and bioequivalence strategy<\/h3>\r\n <p>\r\n Formulation and manufacturing determine the consistency of absorption and success in bioequivalence.\nPBBM simulates the interaction between the active substance, the formulation matrix, and human physiology to guide development decisions.\r\n <\/p>\r\n <br><br>\r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> What PBBM enables<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>CRDS<\/b><span>Clinically relevant dissolution specifications.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Virtual Bioequivalence (vBE)<\/b><span>Virtual bioequivalence & formulation bridging.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Biowaivers<\/b><span>Mechanistic rationale, food effect, antacids.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Screening<\/b><span>Test variants before clinical PK.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Data often available<\/div>\r\n <h3>From API to in vitro dissolution<\/h3>\r\n <p>API characterization, solubility\/permeability profiles, multi-media dissolution testing, and release rate assessments.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Study approach<\/div>\r\n <h3>Design \u2192 simulate \u2192 de-risk<\/h3>\r\n <p>Evaluate formulation options and dissolution specifications in silico, then prioritize the most promising scenarios for clinical PK studies.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Platform<\/div>\r\n <h3>PBBM workflows in GastroPlus\u00ae<\/h3>\r\n <p>PhinC excels in delivering advanced PBBM using GastroPlus, supported by a long-standing collaboration with Simulations Plus.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\" id=\"cta-final\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"cta-final\">\r\n <h3>Turn your data into robust PBPK\/PBBM decisions<\/h3>\r\n <p class=\"translation-block\">With PhinC, secure your key milestones through robust mechanistic modeling: dose selection, FIH scenarios, DDI strategy, formulation optimization, bioequivalence, and bridging.\n\nOur teams combine PBPK and PBBM expertise to deliver traceable, defensible, and decision-oriented analyses.<\/p>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn phinc-btn primary\" href=\"\/en\/contact\/\">\r\n Get in touch\r\n <span aria-hidden=\"true\">\u2197<\/span>\r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n<\/section>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>For a better translation from non-clinical to human studies<\/p>","protected":false},"featured_media":4009,"template":"","meta":{"_acf_changed":false},"domaine":[],"class_list":["post-1421","service","type-service","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>La mod\u00e9lisation PBPK - PBBM - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/service\/pbpk\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La mod\u00e9lisation PBPK - PBBM - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"D\u00e9veloppement optimis\u00e9 d\u00e8s la pr\u00e9-clinique jusqu\u2019aux essais de phase I\/II\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/en\/service\/pbpk\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC 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font-size:20px;\r\n color:var(--phinc-blue);\r\n letter-spacing:-.2px;\r\n }\r\n .cta-final p{\r\n margin:0;\r\n color:var(--muted);\r\n font-size:14.5px;\r\n line-height:1.6;\r\n max-width:92ch;\r\n }\r\n .cta-final .cta-row{ margin-top:16px; }\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .hero-grid{ grid-template-columns:1fr; }\r\n .grid-3{ grid-template-columns:1fr; }\r\n .grid-2{ grid-template-columns:1fr; }\r\n ul.clean.clean--4col{ grid-template-columns: repeat(2, 1fr); }\r\n .card--full{ grid-column:auto; }\r\n .phinc-wrap{ padding:44px 18px; }\r\n }\r\n @media (max-width: 560px){\r\n ul.clean.clean--4col{ grid-template-columns: 1fr; }\r\n }\r\n <\/style>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"hero\">\r\n <div class=\"hero-grid\">\r\n <div>\r\n <div class=\"kicker\">PBPK & PBBM \u2022 Mechanistic Modeling<\/div>\r\n <h2 style=\"margin-top:14px;\">From non-clinical data and formulation design to First-in-Human<\/h2>\r\n <p class=\"subhead translation-block\">PhinC supports development teams with <b>PBPK<\/b> and <b>PBBM<\/b> strategies to anticipate exposure, optimize doses,\n\nsecure key decisions and strengthen regulatory dossiers.<\/p>\r\n\r\n <div class=\"cta-row\">\r\n \r\n<a class=\"btn phinc-btn primary\" href=\"\/en\/case-studies\/#pbpk-case-studies\">\r\n See case studies\r\n \r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-media\" aria-label=\"Cover Phase 1\">\r\n <img decoding=\"async\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/cover-pbpk-800x533-1.jpg\"\r\n alt=\"Couverture Phase 1\"\r\n loading=\"lazy\"\r\n \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Physiology-based pharmacokinetic modeling (PBPK)<\/h2>\r\n <p class=\"lead\">For better translation from non-clinical to human.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Explaining PBPK<\/div>\r\n <h3>A robust mechanistic ADME model<\/h3>\r\n <p class=\"translation-block\">PBPK modeling predicts <b>absorption, distribution, metabolism, and excretion<\/b> by integrating molecule-specific properties and physiological system knowledge within a unified quantitative framework.<\/p>\r\n\r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Anatomy and physiology<\/b><span>Representation of the human or animal body.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Physicochemical properties<\/b><span>Parameters influencing distribution and permeability.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>In vitro Biotransformation<\/b><span>Enzymes, metabolic pathways, intrinsic clearance.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Transportation process<\/b><span>Active\/passive transport across tissues.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Why is it essential<\/div>\r\n <h3>Derisking early clinical development<\/h3>\r\n <p>\r\n PBPK supports dose and dosing regimen selection by explicitly considering physiology,\n\nin vitro metabolism\/transport and inter-individual variability \u2014 reducing the need for extensive in vivo studies and accelerating turnaround times.\r\n <\/p>\r\n<br><br>\r\n \r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> When to use PBPK<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBPK\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>First-in-Human (FIH)<\/b><span>Testing dose scenarios in silico before clinical execution.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Drug-Drug Interactions (DDI)<\/b><span>Estimate the extent of the interactions and support the mitigation strategy.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Special populations<\/b><span>Pediatrics, liver or kidney failure, and other situations.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Food & bridging<\/b><span>Food effect, change in formulation, justification for bridging.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Data often available<\/div>\r\n <h3>Datasets that can be used quickly<\/h3>\r\n <p>Preclinical PK, animal studies, and in vitro metabolism and transport data provide a solid basis for starting a PBPK analysis.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Delivrables<\/div>\r\n <h3>Clear, submission-ready outputs.<\/h3>\r\n <p>Simulation reports, scenario comparisons, sensitivity analyses, full traceability of assumptions, and decision-oriented recommendations.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Platform<\/div>\r\n <h3>GastroPlus\u00ae Expertise<\/h3>\r\n <p>PhinC pioneered the use of GastroPlus\u00ae and maintains a strong partnership with Simulations Plus\u00ae to deploy best-practice PBPK workflows.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-white\">\r\n <div class=\"phinc-wrap\">\r\n\r\n <div class=\"section-head\">\r\n <div>\r\n <h2>Physiology-based biopharmaceutical modeling (PBBM)<\/h2>\r\n <p class=\"lead\">For a better translation from formulation design to in vivo performance<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"grid-2\">\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Explaining PBBM<\/div>\r\n <h3>Mechanistic modeling of absorption and bioavailability<\/h3>\r\n <p class=\"translation-block\">PBBM predicts <b>absorption and bioavailability<\/b> by integrating formulation characteristics with gastrointestinal physiology,\n\nallowing a quantitative link between <b>in vitro<\/b> observations and <b>in vivo<\/b> performance.<\/p>\r\n\r\n \r\n <ul class=\"clean clean--4col\" aria-label=\"Composants de la PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Physicochemical properties<\/b><span>Solubility, permeability, stability (pKa, LogP).<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Formulation models<\/b><span>Dissolution, particle size, release.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Gastrointestinal physiology<\/b><span>pH, transit, first-pass effect, bile.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Variability<\/b><span>Age, GI conditions, patient subgroups.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n \r\n <div class=\"card card--full\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Why is it essential<\/div>\r\n <h3>Optimize formulation and bioequivalence strategy<\/h3>\r\n <p>\r\n Formulation and manufacturing determine the consistency of absorption and success in bioequivalence.\nPBBM simulates the interaction between the active substance, the formulation matrix, and human physiology to guide development decisions.\r\n <\/p>\r\n <br><br>\r\n\r\n <div class=\"tag\"><span class=\"mini\"><\/span> What PBBM enables<\/div>\r\n <ul class=\"clean clean--4col\" aria-label=\"Cas d\u2019usage PBBM\">\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>CRDS<\/b><span>Clinically relevant dissolution specifications.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Virtual Bioequivalence (vBE)<\/b><span>Virtual bioequivalence & formulation bridging.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Biowaivers<\/b><span>Mechanistic rationale, food effect, antacids.<\/span><\/div>\r\n <\/li>\r\n <li class=\"li li--stack\">\r\n <span class=\"tick\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M9.2 16.6 4.9 12.3l-1.4 1.4 5.7 5.7L20.5 8.1l-1.4-1.4z\"\/><\/svg>\r\n <\/span>\r\n <div><b>Screening<\/b><span>Test variants before clinical PK.<\/span><\/div>\r\n <\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <\/div>\r\n\r\n <div class=\"grid-3\">\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Data often available<\/div>\r\n <h3>From API to in vitro dissolution<\/h3>\r\n <p>API characterization, solubility\/permeability profiles, multi-media dissolution testing, and release rate assessments.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Study approach<\/div>\r\n <h3>Design \u2192 simulate \u2192 de-risk<\/h3>\r\n <p>Evaluate formulation options and dissolution specifications in silico, then prioritize the most promising scenarios for clinical PK studies.<\/p>\r\n <\/div>\r\n <div class=\"card\">\r\n <div class=\"tag\"><span class=\"mini\"><\/span> Platform<\/div>\r\n <h3>PBBM workflows in GastroPlus\u00ae<\/h3>\r\n <p>PhinC excels in delivering advanced PBBM using GastroPlus, supported by a long-standing collaboration with Simulations Plus.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-sep\"><\/div>\r\n\r\n \r\n <div class=\"phinc-sec is-gray\" id=\"cta-final\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"cta-final\">\r\n <h3>Turn your data into robust PBPK\/PBBM decisions<\/h3>\r\n <p class=\"translation-block\">With PhinC, secure your key milestones through robust mechanistic modeling: dose selection, FIH scenarios, DDI strategy, formulation optimization, bioequivalence, and bridging.\n\nOur teams combine PBPK and PBBM expertise to deliver traceable, defensible, and decision-oriented analyses.<\/p>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn phinc-btn primary\" href=\"\/en\/contact\/\">\r\n Get in touch\r\n <span aria-hidden=\"true\">\u2197<\/span>\r\n<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n<\/section>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>For a better translation from non-clinical to human studies<\/p>","protected":false},"featured_media":4009,"template":"","meta":{"_acf_changed":false},"domaine":[],"class_list":["post-1421","service","type-service","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>La mod\u00e9lisation PBPK - PBBM - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/service\/pbpk\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La mod\u00e9lisation PBPK - PBBM - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"D\u00e9veloppement optimis\u00e9 d\u00e8s la pr\u00e9-clinique jusqu\u2019aux essais de phase I\/II\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/en\/service\/pbpk\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC 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