{"id":1610,"date":"2026-03-27T11:44:00","date_gmt":"2026-03-27T10:44:00","guid":{"rendered":"https:\/\/www.phinc-group.com\/?p=1610"},"modified":"2026-05-12T11:16:56","modified_gmt":"2026-05-12T09:16:56","slug":"la-modelisation-integree-dans-le-developpement-de-medicaments","status":"publish","type":"post","link":"https:\/\/www.phinc-group.com\/en\/la-modelisation-integree-dans-le-developpement-de-medicaments\/","title":{"rendered":"Modeling &amp; Simulation integrated in drug development"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Fifteen years ago, along with my three partners \u2014all experts from the pharmaceutical industry\u2014 we founded PhinC Development with a bold and disruptive vision: to place modeling at the heart of drug development. At that time, we had already anticipated the evolution of pharmacometric practices and highlighted the benefits of modeling in drug development. Since then, our goal has been to support small and medium-sized pharmaceutical or biotech companies throughout the stages of drug development, from preclinical to proof-of-concept in patients, in an operational and personalized way.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph translation-block\">Over the past 15 years, we have witnessed modeling and simulations play an increasingly crucial role in the successful development of drug candidates. The Model-Informed Drug Development (MIDD) approaches \u2014that we systematically promote\u2014 enable us to accurately predict how drugs will behave in the human body, characterize the pharmacological effect, optimize dosing regimens, and identify and mitigate potential risks before clinical trials even start. By using pharmacokinetic and pharmacodynamic modeling, we can simulate different scenarios enabling us to gain an in-depth understanding of drug mechanisms of action and make key informed decisions throughout the development process. The benefits of modeling and simulation have become undeniable. Not only they save time and resources by reducing the number of required clinical trials, they also help to improve the assessment of safety and efficacy of drugs under development.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Regulators are increasingly recognizing the value of these practices and encouraging their use in the drug approval process. By adopting these innovative approaches, we can not only optimize the development of new therapeutics but also ensure that they meet the highest standards. Moreover, as drug development evolves, modeling approaches have proven to be particularly effective in addressing the specificity and complexity of New Chemical Entities (NCEs) and New Biological Entities (NBEs). These drug candidates often present unique challenges in terms of pharmacokinetics, pharmacodynamics, and safety profiles, and modeling allows us to tailor our strategies to meet these challenges with precision.<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-7387b849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"595\" height=\"340\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/15ans-phinc-600px.1190x0.jpg\" alt=\"\" class=\"wp-image-1611\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/15ans-phinc-600px.1190x0.jpg 595w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/15ans-phinc-600px.1190x0-300x171.jpg 300w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/15ans-phinc-600px.1190x0-18x10.jpg 18w\" sizes=\"(max-width: 595px) 100vw, 595px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Today, we mark an important milestone in our journey. After 15 years in existence, we are more convinced than ever that pharmacometrics and Quantitative System Pharmacology (QSP) provide effective solutions in pharmaceutical development.<\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\">By adopting a holistic approach of all available technologies, we continually enhance our service offerings such as machine learning, artificial intelligence, and advanced bioinformatics platforms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We have always been committed to research, innovation, and collaboration with our partners in the pharmaceutical industry. Our expertise in integrated modeling enables us to tackle the complex challenges of drug development by identifying the best approaches and optimizing clinical strategies. Today, more than ever, as the pharmaceutical industry rapidly evolves, we are proud to contribute to transforming the landscape of drug development by promoting disruptive methodologies.<\/p>","protected":false},"excerpt":{"rendered":"<p>Modeling and simulation play an increasingly crucial role in the development of drug candidates.<\/p>","protected":false},"author":2,"featured_media":1642,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[37],"tags":[],"service-associe":[25],"class_list":["post-1610","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","service-associe-modelisation-integree"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La mod\u00e9lisation int\u00e9gr\u00e9e dans le d\u00e9veloppement de m\u00e9dicaments - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/la-modelisation-integree-dans-le-developpement-de-medicaments\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La mod\u00e9lisation int\u00e9gr\u00e9e dans le d\u00e9veloppement de m\u00e9dicaments - 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