{"id":53,"date":"2024-12-23T16:04:50","date_gmt":"2024-12-23T15:04:50","guid":{"rendered":"https:\/\/www.phinc-group.com\/?page_id=53"},"modified":"2026-05-12T10:21:22","modified_gmt":"2026-05-12T08:21:22","slug":"insights","status":"publish","type":"page","link":"https:\/\/www.phinc-group.com\/en\/insights\/","title":{"rendered":"News"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"53\" class=\"elementor elementor-53\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-abfd242 e-con-full e-flex e-con e-parent\" data-id=\"abfd242\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e2eb609 elementor-widget elementor-widget-shortcode\" data-id=\"e2eb609\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div 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ease,box-shadow .15s ease;\n    text-decoration:none;color:inherit;\n  }\n  .phinc-card:hover{transform:translateY(-3px);box-shadow:var(--shadow);}\n  .phinc-card-img{width:100%;aspect-ratio:16\/9;object-fit:cover;display:block;}\n  .phinc-card-img-placeholder{\n    width:100%;aspect-ratio:16\/9;\n    background:linear-gradient(135deg,rgba(0,0,95,.05),rgba(217,75,159,.09));\n    display:flex;align-items:center;justify-content:center;\n  }\n  .phinc-card-img-placeholder svg{opacity:.22;}\n  .phinc-card-body{padding:18px 20px 22px;flex:1;display:flex;flex-direction:column;gap:8px;}\n  .phinc-card-cat{font-size:11px;letter-spacing:.12em;text-transform:uppercase;color:var(--phinc-pink);font-weight:700;}\n  .phinc-card-title{font-size:15px;font-weight:700;line-height:1.35;letter-spacing:-.01em;margin:0;}\n  .phinc-card-excerpt{\n    font-size:13px;color:var(--muted);line-height:1.6;font-weight:300;margin:0;flex:1;\n    display:-webkit-box;-webkit-line-clamp:3;-webkit-box-orient:vertical;overflow:hidden;\n  }\n  .phinc-card-meta{display:flex;align-items:center;gap:8px;font-size:12px;color:var(--muted);font-weight:300;margin-top:4px;}\n\n  \/* \u2500\u2500 LOAD MORE \u2500\u2500 *\/\n  .phinc-loadmore-wrap{text-align:center;margin-top:36px;padding-bottom:56px;}\n  .phinc-loadmore{\n    display:inline-flex;align-items:center;gap:8px;\n    padding:14px 28px;border-radius:12px;\n    border:1px solid var(--line);background:#fff;\n    font-size:14px;font-weight:700;color:var(--ink);cursor:pointer;\n    transition:transform .12s ease,box-shadow .12s ease;\n  }\n  .phinc-loadmore:hover{transform:translateY(-1px);box-shadow:var(--shadow);}\n  .phinc-card.phinc-hidden{display:none;}\n\n  \/* \u2500\u2500 RESPONSIVE \u2500\u2500 *\/\n  @media(max-width:900px){\n    .phinc-featured{grid-template-columns:1fr;}\n    .phinc-featured-img,.phinc-featured-img-placeholder{min-height:220px;}\n    .phinc-grid-news{grid-template-columns:1fr 1fr;}\n    .phinc-h1{font-size:32px;}\n  }\n  @media(max-width:600px){\n    .phinc-grid-news{grid-template-columns:1fr;}\n    .phinc-featured-body{padding:22px 18px;}\n  }\n  <\/style>\n\n  <!-- HERO -->\n  <header class=\"phinc-hero-news\">\n    <div class=\"phinc-eyebrow\"><span class=\"phinc-dot\"><\/span> Latest from PhinC<\/div>\n    <h1 class=\"phinc-h1\">Stay connected to the heart of our business<\/h1>\n    <p class=\"phinc-sub\">Explore our latest publications, congress participation, new expertise, and insights in model-informed drug development.<\/p>\n  <\/header>\n\n  <!-- \u2550\u2550 FEATURED \u2014 cat\u00e9gorie \"Main\" \u2550\u2550 -->\n    <div class=\"phinc-featured-wrap\">\n    <a class=\"phinc-featured\" href=\"https:\/\/www.phinc-group.com\/en\/pbbm-connecting-drug-product-performance-to-clinical-outcomes\/\">\n      <div>\n                  <img decoding=\"async\" class=\"phinc-featured-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/09\/comprime-performances-resultats-phinc-PBBM-1024x768.png\" alt=\"PBBM : Relier les performances du produit m\u00e9dicamenteux aux r\u00e9sultats cliniques\" loading=\"lazy\">\n              <\/div>\n      <div class=\"phinc-featured-body\">\n        <span class=\"phinc-badge\">Featured<\/span>\n        <h2 class=\"phinc-featured-title\">PBBM: connecting drug product performance to clinical outcomes<\/h2>\n        <p class=\"phinc-featured-excerpt\">Physiologically Based Biopharmaceutics Modeling (PBBM) is no longer a peripheral, exploratory tool and has emerged as a central pillar in modern formulation development and an increasingly important component of Model-Informed Drug Development (MIDD) and regulatory decision-making.<\/p>\n        <div class=\"phinc-featured-meta\">\n          <span>9 Sep 2026<\/span>\n        <\/div>\n        <span class=\"phinc-featured-link\">\n          Read more\n          <svg width=\"14\" height=\"14\" viewbox=\"0 0 16 16\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\"><line x1=\"2\" y1=\"8\" x2=\"14\" y2=\"8\"\/><polyline points=\"9 3 14 8 9 13\"\/><\/svg>\n        <\/span>\n      <\/div>\n    <\/a>\n  <\/div>\n  \n  <!-- \u2550\u2550 GRILLE \u2014 tous les posts \u2550\u2550 -->\n    <div class=\"phinc-wrap phinc-grid-section\">\n    <div class=\"phinc-grid-news\" id=\"phinc-grid\">\n\n    \n      <a class=\"phinc-card\" href=\"https:\/\/www.phinc-group.com\/en\/phinc-corealis\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/09\/thumbnail-corealis-phinc-768x506.png\" alt=\"PhinC | Corealis : Expertise en formulation et mod\u00e9lisation pr\u00e9dictive\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">PRESS RELEASE<\/span>\n                    <h3 class=\"phinc-card-title\">PhinC | Corealis : Combining formulation expertise and predictive modeling<\/h3>\n          <p class=\"phinc-card-excerpt\">A strategic collaboration to integrate PBBM Modeling and PBPK modeling directly into oral solid dosage form development.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>16 Sep 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card\" href=\"https:\/\/www.phinc-group.com\/en\/pbbm-connecting-drug-product-performance-to-clinical-outcomes\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/09\/comprime-performances-resultats-phinc-PBBM-768x576.png\" alt=\"PBBM : Relier les performances du produit m\u00e9dicamenteux aux r\u00e9sultats cliniques\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Featured<\/span>\n                    <h3 class=\"phinc-card-title\">PBBM: connecting drug product performance to clinical outcomes<\/h3>\n          <p class=\"phinc-card-excerpt\">Physiologically Based Biopharmaceutics Modeling (PBBM) is no longer a peripheral, exploratory tool and has emerged as a central pillar in modern formulation development and an increasingly important component of Model-Informed Drug Development (MIDD) and regulatory decision-making.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>9 Sep 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card\" href=\"https:\/\/www.phinc-group.com\/en\/attentes-reglementaire-midd\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/07\/regulatory-expectations-MIDD-1200x900-1-768x576.png\" alt=\"Naviguer dans les attentes r\u00e9glementaires du d\u00e9veloppement de m\u00e9dicaments fond\u00e9 sur la mod\u00e9lisation\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Blog<\/span>\n                    <h3 class=\"phinc-card-title\">Navigating regulatory expectations in Model-Informed Drug Development<\/h3>\n          <p class=\"phinc-card-excerpt\">Longtemps cantonn\u00e9e au rang d'approche exp\u00e9rimentale, la mod\u00e9lisation au service du d\u00e9veloppement du m\u00e9dicament (MIDD \u2013 Model-Informed Drug Development) s'impose aujourd'hui comme\u2026<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>23 Jul 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card\" href=\"https:\/\/www.phinc-group.com\/en\/avoiding-late-stage-failure-in-oncology\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/07\/late-stage-failure-in-oncology-4-3-ratio-768x576.png\" alt=\"Eviter les \u00e9checs de stade avanc\u00e9 en oncologie\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Blog<\/span>\n                    <h3 class=\"phinc-card-title\">Avoiding Late-Stage Failure in Oncology Through MIDD<\/h3>\n          <p class=\"phinc-card-excerpt\">Late-stage attrition in oncology drug development represents a substantial scientific and economic inefficiency, with Phase III failure rates often exceeding 50%<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>20 Jul 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card\" href=\"https:\/\/www.phinc-group.com\/en\/a-guide-to-the-fda-announcement-to-phase-out-animal-testing\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/06\/FDA-Approval-MIDD-File-768x576.png\" alt=\"Guide de l&rsquo;annonce de la FDA sur l&rsquo;abandon progressif des tests sur les animaux\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Insights<\/span>\n                    <h3 class=\"phinc-card-title\">A guide to the FDA announcement to phase out animal testing<\/h3>\n          <p class=\"phinc-card-excerpt\">The landscape of preclinical drug development is undergoing a paradigm shift driven by the need for more human-relevant evidence and a global regulatory movement toward ethical safety testing.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>26 Jun 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card\" href=\"https:\/\/www.phinc-group.com\/en\/dose-optimization-in-oncology\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/06\/image-a-la-une-midd-challenge-oncology-optimus-project-768x527.png\" alt=\"Optimisation\u00a0de la dose\u00a0en\u00a0oncologie\u00a0: un\u00a0d\u00e9fi\u00a0cach\u00e9\u00a0du MIDD \u00e0\u00a0l&rsquo;\u00e8re\u00a0du\u00a0projet\u00a0Optimus\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Blog<\/span>\n                    <h3 class=\"phinc-card-title\">Dose optimization in oncology: a hidden MIDD challenge in the era of project Optimus<\/h3>\n          <p class=\"phinc-card-excerpt\">For decades, oncology followed a simple principle: administer the maximum tolerated dose. With modern therapies, this paradigm no longer holds \u2014 discover how MIDD addresses the FDA's new Project Optimus expectations.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>15 Jun 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card phinc-hidden\" href=\"https:\/\/www.phinc-group.com\/en\/midd-stop-guessing-start-modeling\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/06\/MIDD-Stop-Guessing-Thumbnail-768x505.png\" alt=\"MIDD : Arr\u00eatez de deviner, commencez \u00e0 mod\u00e9liser !\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Expertise<\/span>\n                    <h3 class=\"phinc-card-title\">MIDD: stop guessing, start modeling.<\/h3>\n          <p class=\"phinc-card-excerpt\">MIDD transforms drug development: predictive modeling, optimized dose selection, and stronger regulatory dialogue \u2014 from the earliest stages of development.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>4 Jun 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card phinc-hidden\" href=\"https:\/\/www.phinc-group.com\/en\/10-bonnes-raisons-dutiliser-la-modelisation-et-la-simulation\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/10-GOOD-reasons.jpg\" alt=\"10 bonnes raisons d&rsquo;utiliser la Mod\u00e9lisation et la Simulation dans le d\u00e9veloppement de m\u00e9dicament\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Insights<\/span>\n                    <h3 class=\"phinc-card-title\">10 good reasons to use Modeling and Simulation in your drug development<\/h3>\n          <p class=\"phinc-card-excerpt\">Modeling expertise is an essential building block for an optimal drug development strategy.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>11 May 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card phinc-hidden\" href=\"https:\/\/www.phinc-group.com\/en\/adc-pk-in-cancer-patients-using-pbpk-modeling\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/07\/bannere-chiara-2.jpg\" alt=\"Publication : D\u00e9veloppement d&rsquo;un mod\u00e8le PBPK pour les ADC (Oncologie)\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Expertise<\/span>\n                    <h3 class=\"phinc-card-title\">Publication: Development of a PBPK Model for ADC (oncology)<\/h3>\n          <p class=\"phinc-card-excerpt\">A first-in-class PBPK model for CLDN18.2-targeted ADCs using PK-Sim\u00ae and MoBi\u00ae. Read and discover the full article!<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>25 Apr 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card phinc-hidden\" href=\"https:\/\/www.phinc-group.com\/en\/fda-announces-plan-to-phase-out-animal-testing\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/03\/AdobeStock_323811316_Editorial_Use_Only-768x512.jpeg\" alt=\"FDA announces plan to phase out animal testing requirement for mAbs and other drugs\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Insights<\/span>\n                    <h3 class=\"phinc-card-title\">FDA announces plan to phase out animal testing requirement for mAbs and other drugs<\/h3>\n          <p class=\"phinc-card-excerpt\">The FDA is taking a groundbreaking step to advance public health by replacing animal testing in the development of mAbs therapies and\u2026<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>10 Apr 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card phinc-hidden\" href=\"https:\/\/www.phinc-group.com\/en\/la-modelisation-integree-dans-le-developpement-de-medicaments\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/hand-medicine-pills.1293x527-768x313.jpg\" alt=\"La mod\u00e9lisation int\u00e9gr\u00e9e dans le d\u00e9veloppement de m\u00e9dicaments\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Blog<\/span>\n                    <h3 class=\"phinc-card-title\">Modeling &amp; Simulation integrated in drug development<\/h3>\n          <p class=\"phinc-card-excerpt\">Modeling and simulation play an increasingly crucial role in the development of drug candidates.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>27 Mar 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card phinc-hidden\" href=\"https:\/\/www.phinc-group.com\/en\/nouvel-article-unlocking-the-power-of-pbpk-prediction\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/virginie-vignette.jpg\" alt=\"Nouvel article : Lib\u00e9rez tout le potentiel de la pr\u00e9diction PBPK !\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Blog<\/span>\n                    <h3 class=\"phinc-card-title\">New article: Unlock the power of PBPK Prediction!<\/h3>\n          <p class=\"phinc-card-excerpt\">In the ever-evolving landscape of pharmaceutical\nresearch, the quest for developing safer and more effective drugs is a continuous endeavor.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>25 Feb 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n      <a class=\"phinc-card phinc-hidden\" href=\"https:\/\/www.phinc-group.com\/en\/midd-ich-m15\/\">\n                  <img decoding=\"async\" class=\"phinc-card-img\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/samia-featured_post-800x526-1-768x505.png\" alt=\"La MIDD et la FDA : Ce que les Biotechs doivent savoir sur l&rsquo;ICH M15\" loading=\"lazy\">\n                <div class=\"phinc-card-body\">\n                      <span class=\"phinc-card-cat\">Expertise<\/span>\n                    <h3 class=\"phinc-card-title\">MIDD and FDA: What Biotechs need to know about ICH M15<\/h3>\n          <p class=\"phinc-card-excerpt\">The ICH M15 guidance introduces a harmonized framework that allows these models to be formally recognized as \u201cMIDD evidence\u201d by regulatory authorities such as the FDA.<\/p>\n          <div class=\"phinc-card-meta\">\n            <span>1 Jan 2026<\/span>\n          <\/div>\n        <\/div>\n      <\/a>\n\n    \n    <\/div>\n\n        <div class=\"phinc-loadmore-wrap\">\n      <button class=\"phinc-loadmore\" id=\"phinc-loadmore\" onclick=\"phincLoadMore()\">\n        Voir plus d'actualit\u00e9s\n        <svg width=\"16\" height=\"16\" viewbox=\"0 0 16 16\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\"><line x1=\"8\" y1=\"2\" x2=\"8\" y2=\"14\"\/><polyline points=\"4 10 8 14 12 10\"\/><\/svg>\n      <\/button>\n    <\/div>\n    \n  <\/div>\n  \n  <script>\n  (function(){\n    var STEP = 6;\n    function phincLoadMore(){\n      var btn    = document.getElementById('phinc-loadmore');\n      var hidden = document.querySelectorAll('#phinc-grid .phinc-card.phinc-hidden');\n      var toShow = Array.prototype.slice.call(hidden, 0, STEP);\n      toShow.forEach(function(card){ card.classList.remove('phinc-hidden'); 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