PhinC \u2014 Case Studies (T\u00e9l\u00e9chargement)<\/title>\r\n <style>\r\n :root{\r\n --phinc-navy:#00005f;\r\n --phinc-pink:#f947ac;\r\n --bg:#fbfafc;\r\n --card:#ffffff;\r\n --text:#0b0b1a;\r\n --muted:#4a4a68;\r\n --border:rgba(0,0,95,.12);\r\n --shadow:0 14px 40px rgba(0,0,0,.08);\r\n --radius:18px;\r\n --max:1180px;\r\n }\r\n html{scroll-behavior:smooth;}\r\n body{margin:0;font-family:system-ui,-apple-system,Segoe UI,Roboto,Helvetica,Arial,sans-serif;background:var(--bg);color:var(--text);}\r\n a{color:inherit}\r\n .wrap{max-width:var(--max);margin:0 auto;padding:0 18px;}\r\n\r\n \/* Hero *\/\r\n .hero{padding:50px 0 50px;background:#ffffff;}\r\n .hero-grid{display:grid;grid-template-columns:1.05fr .95fr;gap:22px;align-items:stretch;}\r\n @media (max-width: 980px){.hero-grid{grid-template-columns:1fr;}}\r\n .hero-card{border:none;box-shadow:none;background:#ffffff;}\r\n .hero-body{padding:0px;\r\n max-width:53ch;\r\n }\r\n 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var(--border);\r\n border-radius:var(--radius);\r\n box-shadow:var(--shadow);\r\n overflow:hidden;\r\n }\r\n .form-head{padding:22px 22px 0;}\r\n .form-head h2{margin:0 0 6px;color:var(--phinc-navy);font-size:22px;}\r\n .form-head p{margin:0 0 14px;color:var(--muted);font-size:14px;line-height:1.55;}\r\n form{padding:0 22px 22px;}\r\n .fields{display:grid;grid-template-columns:1fr 1fr;gap:12px;}\r\n @media (max-width: 640px){.fields{grid-template-columns:1fr;}}\r\n .field label{display:block;font-size:13px;font-weight:800;color:var(--text);margin:0 0 6px;}\r\n .field input, .field select{\r\n width:100%;\r\n padding:11px 12px;\r\n border-radius:12px;\r\n border:1px solid var(--border);\r\n outline:none;\r\n font-size:14px;\r\n background:#fff;\r\n color:var(--text);\r\n }\r\n .field input:focus, .field select:focus{\r\n border-color:rgba(249,71,172,.55);\r\n box-shadow:0 0 0 4px rgba(249,71,172,.12);\r\n }\r\n .full{grid-column:1 \/ -1;}\r\n .checks{margin-top:12px;display:grid;gap:10px;}\r\n .check{display:flex;gap:10px;align-items:flex-start;color:var(--muted);font-size:13px;line-height:1.45;}\r\n .check input{margin-top:2px;transform:scale(1.05);}\r\n .check a{color:var(--phinc-navy);text-decoration:underline;}\r\n .req{color:var(--phinc-pink);}\r\n .success{\r\n display:none;\r\n margin:12px 22px 0;\r\n padding:12px 14px;\r\n border-radius:14px;\r\n border:1px solid rgba(0,0,95,.14);\r\n background:#fff;\r\n color:var(--text);\r\n font-size:13px;\r\n line-height:1.45;\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n \r\n <header class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"hero-grid\">\r\n <div class=\"hero-card\">\r\n <div class=\"hero-body\">\r\n <h2>Real case studies illustrating the impact of modeling<\/h2>\r\n\r\n <p class=\"lead translation-block\">These case studies are derived from <strong>modeling projects conducted by PhinC<\/strong>\nfor biotech and pharmaceutical companies, across various stages of development.<\/p>\r\n\r\n <ul class=\"hero-bullets\">\r\n <li><strong>The molecule and its development context<\/strong><\/li>\r\n <li><strong>The client\u2019s scientific or clinical challenge<\/strong><\/li>\r\n <li class=\"translation-block\">The<b> approach<\/b> implemented by PhinC (PopPK, PK\/PD, PBPK\u2026)<\/li>\r\n <li class=\"translation-block\">The concrete<strong> contribution of modeling<\/strong>: informed decision-making, dose strategy, optimized study design, regulatory justification, etc.<\/li>\r\n <\/ul>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn btn-ghost\" href=\"#pbpk-case-studies\">See case studies<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-card\" aria-label=\"Illustration hero\">\r\n <img decoding=\"async\" class=\"hero-img\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2024\/12\/shutterstock_407609158.jpg\"\r\n alt=\"Illustration pharmacom\u00e9trie\"\r\n loading=\"lazy\" \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/header>\r\n\r\n \r\n <main class=\"section\" id=\"pbpk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Advance your DDI strategy with PhinC\u2019s PBPK expertise<\/h2>\r\n <\/div>\r\n <p>Whether you are preparing a First-in-Human study, assessing enzyme and transporter liabilities, or building a regulatory-ready DDI strategy, PhinC\u2019s PBPK methodology and Standard Library provide the mechanistic insight needed for confident decision-making.<br><br> <b>See how our approach drives measurable impact<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI Prediction using pre-clinical data only<\/h3>\r\n <p>The sponsor required early human DDI risk assessment to confidently support FIH dose selection and clinical planning.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\"\r\n href=\"#download-form\"\r\n data-case=\"CS01\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI_Prediction-using-pre-clinical-data.pdf\">\r\n Download\r\n <\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI exploration for a drug with complex pharmacokinetics<\/h3>\r\n <p>The sponsor needed a mechanistic understanding of DDIs in order to anticipate clinical risk and guide further development.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS02\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI-Exploration-for-a-drug-with-Complex-Pharmacokinetics.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Mechanism identification of complex DDI using PBPK<\/h3>\r\n <p>The sponsor was to characterize complex drug interactions (DDIs) involving multiple co-administered drugs.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS03\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Mechanism-Identification-of-Complex-DDI.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 4\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Network interaction PBPK modeling for complex victim-perpetrator DDIs<\/h3>\r\n <p>A development program aimed at accurately predicting drug interactions (DDIs) for a molecule \"X\".<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS04\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Modeling-for-Complex-Victim-Perpetrator-DDI.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 5\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>PBPK model development and comprehensive DDI assessment of oral solution <\/h3>\r\n <p>The sponsor required a robust, regulatory-ready PBPK model to support DDI risk assessment.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS05\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Model-Development-and-Comprehensive-DDI-Assessment-of-Oral-Solution.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 6\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 FIH<\/p>\r\n <h3>PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/h3>\r\n <p>A development program required a reliable First-in-Human (FIH) dose prediction based solely on preclinical pharmacokinetic data.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS06\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/PBPK-Modeling-Using-Pre-Clinical-Data-for-FIH-Translation.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n <div class=\"section-divider\"><\/div>\r\n\r\n \r\n <main class=\"section\" id=\"poppk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Transform your clinical data into decisions with the PopPK approach <\/h2>\r\n <\/div>\r\n <p>Whether you aim to understand interindividual variability, identify clinically relevant covariates, or optimize dose selection for your Phase II\/III studies, PhinC\u2019s PopPK approach delivers the quantitative insight needed for robust, regulator-aligned decisions.<br><br> <b>See how our approach drives measurable impact<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 7\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>An iterative, Population PK approach to inform Dosing\r\nStrategy in Human African Trypanosomiasis (HAT)<\/h3>\r\n <p>Definition of an optimal IMP dosing regimen and an effective PK sampling strategy for adults with human African trypanosomiasis (HAT)<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS07\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-to-Inform-Dosing-Strategy-in-Human-African-Trypanosomiasis.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 8\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III <\/h3>\r\n <p>The sponsor requested the development of a complete PopPK model based on a pediatric population with HAT (Phase III).<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS08\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-Modeling-to-Inform-Pediatric-Dosing-in-Human-African-Trypanosomiasis-in-Phase-3.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n \r\n <section class=\"form-section\" id=\"download-form\">\r\n <div class=\"wrap\">\r\n <div class=\"form-card\">\r\n <div class=\"form-head\">\r\n <h2>Download our case studies<\/h2>\r\n <p>Fill the form to receive an email with the download link.<\/p>\r\n <\/div>\r\n\r\n <div class=\"success\" id=\"successBox\" style=\"display:none;\">\r\n \u2705 Thank you for your interest in our work. You should receive your download link by email within the next few minutes.\r\n <br><span style=\"opacity:.85;\">If you don\u2019t see it, please check your spam folder.<\/span>\r\n <\/div>\r\n\r\n \r\n <form id=\"phincForm\" action=\"https:\/\/www.phinc-group.com\/wp-admin\/admin-post.php\" method=\"post\">\r\n <input type=\"hidden\" name=\"action\" value=\"phinc_send_case_study\">\r\n <input type=\"hidden\" id=\"pdf_link\" name=\"pdf_link\" value=\"\">\r\n <input type=\"hidden\" id=\"case_code\" name=\"case_code\" value=\"\">\r\n\r\n <div class=\"fields\">\r\n <div class=\"field\">\r\n <label for=\"firstname\">First name <span class=\"req\">*<\/span><\/label>\r\n <input id=\"firstname\" name=\"firstname\" type=\"text\" autocomplete=\"given-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field\">\r\n <label for=\"lastname\">Last name <span class=\"req\">*<\/span><\/label>\r\n <input id=\"lastname\" name=\"lastname\" type=\"text\" autocomplete=\"family-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"company\">Company <span class=\"req\">*<\/span><\/label>\r\n <input id=\"company\" name=\"company\" type=\"text\" autocomplete=\"organization\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"email\">Email <span class=\"req\">*<\/span><\/label>\r\n <input id=\"email\" name=\"email\" type=\"email\" autocomplete=\"email\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"case_selected\">Case study selected<\/label>\r\n <select id=\"case_selected\" name=\"case_selected\">\r\n <option value=\"\">Choisir <\/option>\r\n <option value=\"CS01\">CS01 \u2014 DDI Prediction Using Pre-Clinical Data Only<\/option>\r\n <option value=\"CS02\">CS02 \u2014 DDI Exploration for a drug with Complex Pharmacokinetics<\/option>\r\n <option value=\"CS03\">CS03 \u2014 Mechanism Identification of Complex DDI using Predictive PBPK Modeling<\/option>\r\n <option value=\"CS04\">CS04 \u2014 Network Interaction PBPK Modeling for Complex Victim-Perpetrator DDIs<\/option>\r\n <option value=\"CS05\">CS05 \u2014 PBPK Model Development and Comprehensive DDI Assessment of Oral Solution<\/option>\r\n <option value=\"CS06\">CS06 \u2014 PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/option>\r\n <option value=\"CS07\">CS07 \u2014 An iterative, Population PK approach to inform Dosing Strategy in Human African Trypanosomiasis (HAT)<\/option>\r\n<option value=\"CS08\">CS08 \u2014 Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III development.<\/option>\r\n \r\n <\/select>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"checks\">\r\n <label class=\"check\">\r\n <input type=\"checkbox\" name=\"privacy\" value=\"1\" required>\r\n <span>\r\n I confirm that I have read and accept the\r\n <a href=\"\/en\/politique-de-confidentialite\/\" target=\"_blank\" rel=\"noopener\">privacy policy<\/a>\r\n de PhinC <span class=\"req\">*<\/span>\r\n <\/span>\r\n <\/label>\r\n\r\n <label class=\"check\">\r\n <input type=\"checkbox\" name=\"contact_optin\" value=\"1\">\r\n <span>I agree to be contacted by PhinC regarding its services.<\/span>\r\n <\/label>\r\n <\/div>\r\n\r\n <button class=\"btn btn-primary\" type=\"submit\" style=\"margin-top:24px;width:20%;\">\r\n Get the link\r\n <\/button>\r\n <\/form>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <script>\r\n (function(){\r\n \/\/ 1) Show thank-you message if sent=1\r\n const params = new URLSearchParams(window.location.search);\r\n if (params.get('sent') === '1') {\r\n const box = document.getElementById('successBox');\r\n if (box) box.style.display = 'block';\r\n }\r\n\r\n \/\/ 2) Pre-fill selected case when clicking a card CTA\r\n const select = document.getElementById('case_selected');\r\n const pdfInput = document.getElementById('pdf_link');\r\n const caseInput = document.getElementById('case_code');\r\n const downloadLinks = document.querySelectorAll('.phinc-download');\r\n\r\n downloadLinks.forEach(a => {\r\n a.addEventListener('click', () => {\r\n const code = a.getAttribute('data-case') || '';\r\n const pdf = a.getAttribute('data-pdf') || '';\r\n if (select && code) select.value = code;\r\n if (pdfInput) pdfInput.value = pdf;\r\n if (caseInput) caseInput.value = code;\r\n });\r\n });\r\n })();\r\n <\/script>\r\n\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Real projects, real impact \u2014 explore how PhinC’s modeling expertise has shaped drug development strategies across therapeutic areas and development stages.<\/p>","protected":false},"author":2,"featured_media":4548,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3980","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>Case studies - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/case-studies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Case studies - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"Real projects, real impact \u2014 explore how PhinC's modeling expertise has shaped drug development strategies across therapeutic areas and development stages.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/en\/case-studies\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC Group\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-30T08:40:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2024\/12\/cases-menu-thumbnail-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/case-studies\\\/\",\"url\":\"https:\\\/\\\/www.phinc-group.com\\\/case-studies\\\/\",\"name\":\"Case studies - 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var(--border);\r\n border-radius:var(--radius);\r\n box-shadow:var(--shadow);\r\n overflow:hidden;\r\n }\r\n .form-head{padding:22px 22px 0;}\r\n .form-head h2{margin:0 0 6px;color:var(--phinc-navy);font-size:22px;}\r\n .form-head p{margin:0 0 14px;color:var(--muted);font-size:14px;line-height:1.55;}\r\n form{padding:0 22px 22px;}\r\n .fields{display:grid;grid-template-columns:1fr 1fr;gap:12px;}\r\n @media (max-width: 640px){.fields{grid-template-columns:1fr;}}\r\n .field label{display:block;font-size:13px;font-weight:800;color:var(--text);margin:0 0 6px;}\r\n .field input, .field select{\r\n width:100%;\r\n padding:11px 12px;\r\n border-radius:12px;\r\n border:1px solid var(--border);\r\n outline:none;\r\n font-size:14px;\r\n background:#fff;\r\n color:var(--text);\r\n }\r\n .field input:focus, .field select:focus{\r\n border-color:rgba(249,71,172,.55);\r\n box-shadow:0 0 0 4px rgba(249,71,172,.12);\r\n }\r\n .full{grid-column:1 \/ -1;}\r\n .checks{margin-top:12px;display:grid;gap:10px;}\r\n .check{display:flex;gap:10px;align-items:flex-start;color:var(--muted);font-size:13px;line-height:1.45;}\r\n .check input{margin-top:2px;transform:scale(1.05);}\r\n .check a{color:var(--phinc-navy);text-decoration:underline;}\r\n .req{color:var(--phinc-pink);}\r\n .success{\r\n display:none;\r\n margin:12px 22px 0;\r\n padding:12px 14px;\r\n border-radius:14px;\r\n border:1px solid rgba(0,0,95,.14);\r\n background:#fff;\r\n color:var(--text);\r\n font-size:13px;\r\n line-height:1.45;\r\n }\r\n <\/style>\r\n<\/head>\r\n\r\n<body>\r\n \r\n <header class=\"hero\">\r\n <div class=\"wrap\">\r\n <div class=\"hero-grid\">\r\n <div class=\"hero-card\">\r\n <div class=\"hero-body\">\r\n <h2>Real case studies illustrating the impact of modeling<\/h2>\r\n\r\n <p class=\"lead translation-block\">These case studies are derived from <strong>modeling projects conducted by PhinC<\/strong>\nfor biotech and pharmaceutical companies, across various stages of development.<\/p>\r\n\r\n <ul class=\"hero-bullets\">\r\n <li><strong>The molecule and its development context<\/strong><\/li>\r\n <li><strong>The client\u2019s scientific or clinical challenge<\/strong><\/li>\r\n <li class=\"translation-block\">The<b> approach<\/b> implemented by PhinC (PopPK, PK\/PD, PBPK\u2026)<\/li>\r\n <li class=\"translation-block\">The concrete<strong> contribution of modeling<\/strong>: informed decision-making, dose strategy, optimized study design, regulatory justification, etc.<\/li>\r\n <\/ul>\r\n\r\n <div class=\"cta-row\">\r\n <a class=\"btn btn-ghost\" href=\"#pbpk-case-studies\">See case studies<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"hero-card\" aria-label=\"Illustration hero\">\r\n <img decoding=\"async\" class=\"hero-img\"\r\n src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2024\/12\/shutterstock_407609158.jpg\"\r\n alt=\"Illustration pharmacom\u00e9trie\"\r\n loading=\"lazy\" \/>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/header>\r\n\r\n \r\n <main class=\"section\" id=\"pbpk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Advance your DDI strategy with PhinC\u2019s PBPK expertise<\/h2>\r\n <\/div>\r\n <p>Whether you are preparing a First-in-Human study, assessing enzyme and transporter liabilities, or building a regulatory-ready DDI strategy, PhinC\u2019s PBPK methodology and Standard Library provide the mechanistic insight needed for confident decision-making.<br><br> <b>See how our approach drives measurable impact<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI Prediction using pre-clinical data only<\/h3>\r\n <p>The sponsor required early human DDI risk assessment to confidently support FIH dose selection and clinical planning.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\"\r\n href=\"#download-form\"\r\n data-case=\"CS01\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI_Prediction-using-pre-clinical-data.pdf\">\r\n Download\r\n <\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 2\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>DDI exploration for a drug with complex pharmacokinetics<\/h3>\r\n <p>The sponsor needed a mechanistic understanding of DDIs in order to anticipate clinical risk and guide further development.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS02\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-DDI-Exploration-for-a-drug-with-Complex-Pharmacokinetics.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 3\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Mechanism identification of complex DDI using PBPK<\/h3>\r\n <p>The sponsor was to characterize complex drug interactions (DDIs) involving multiple co-administered drugs.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS03\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Mechanism-Identification-of-Complex-DDI.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 4\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>Network interaction PBPK modeling for complex victim-perpetrator DDIs<\/h3>\r\n <p>A development program aimed at accurately predicting drug interactions (DDIs) for a molecule \"X\".<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS04\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Modeling-for-Complex-Victim-Perpetrator-DDI.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 5\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 DDI<\/p>\r\n <h3>PBPK model development and comprehensive DDI assessment of oral solution <\/h3>\r\n <p>The sponsor required a robust, regulatory-ready PBPK model to support DDI risk assessment.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS05\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/PBPK-Model-Development-and-Comprehensive-DDI-Assessment-of-Oral-Solution.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 6\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PBPK \u2022 FIH<\/p>\r\n <h3>PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/h3>\r\n <p>A development program required a reliable First-in-Human (FIH) dose prediction based solely on preclinical pharmacokinetic data.<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS06\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/PBPK-Modeling-Using-Pre-Clinical-Data-for-FIH-Translation.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n <div class=\"section-divider\"><\/div>\r\n\r\n \r\n <main class=\"section\" id=\"poppk-case-studies\">\r\n <div class=\"wrap\">\r\n <div class=\"section-title\">\r\n <h2>Transform your clinical data into decisions with the PopPK approach <\/h2>\r\n <\/div>\r\n <p>Whether you aim to understand interindividual variability, identify clinically relevant covariates, or optimize dose selection for your Phase II\/III studies, PhinC\u2019s PopPK approach delivers the quantitative insight needed for robust, regulator-aligned decisions.<br><br> <b>See how our approach drives measurable impact<\/b><\/p>\r\n\r\n <div class=\"cards\">\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 7\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>An iterative, Population PK approach to inform Dosing\r\nStrategy in Human African Trypanosomiasis (HAT)<\/h3>\r\n <p>Definition of an optimal IMP dosing regimen and an effective PK sampling strategy for adults with human African trypanosomiasis (HAT)<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS07\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-to-Inform-Dosing-Strategy-in-Human-African-Trypanosomiasis.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <article class=\"card\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 8\" loading=\"lazy\">\r\n <div class=\"card-body\">\r\n <p class=\"tag\">PopPK<\/p>\r\n <h3>Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III <\/h3>\r\n <p>The sponsor requested the development of a complete PopPK model based on a pediatric population with HAT (Phase III).<\/p>\r\n <div class=\"card-cta\">\r\n <a class=\"btn btn-ghost btn-sm phinc-download\" href=\"#download-form\"\r\n data-case=\"CS08\"\r\n data-pdf=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/03\/Pop-PK-Modeling-to-Inform-Pediatric-Dosing-in-Human-African-Trypanosomiasis-in-Phase-3.pdf\">Download<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/article>\r\n <\/div>\r\n <\/div>\r\n <\/main>\r\n\r\n \r\n <section class=\"form-section\" id=\"download-form\">\r\n <div class=\"wrap\">\r\n <div class=\"form-card\">\r\n <div class=\"form-head\">\r\n <h2>Download our case studies<\/h2>\r\n <p>Fill the form to receive an email with the download link.<\/p>\r\n <\/div>\r\n\r\n <div class=\"success\" id=\"successBox\" style=\"display:none;\">\r\n \u2705 Thank you for your interest in our work. You should receive your download link by email within the next few minutes.\r\n <br><span style=\"opacity:.85;\">If you don\u2019t see it, please check your spam folder.<\/span>\r\n <\/div>\r\n\r\n \r\n <form id=\"phincForm\" action=\"https:\/\/www.phinc-group.com\/wp-admin\/admin-post.php\" method=\"post\">\r\n <input type=\"hidden\" name=\"action\" value=\"phinc_send_case_study\">\r\n <input type=\"hidden\" id=\"pdf_link\" name=\"pdf_link\" value=\"\">\r\n <input type=\"hidden\" id=\"case_code\" name=\"case_code\" value=\"\">\r\n\r\n <div class=\"fields\">\r\n <div class=\"field\">\r\n <label for=\"firstname\">First name <span class=\"req\">*<\/span><\/label>\r\n <input id=\"firstname\" name=\"firstname\" type=\"text\" autocomplete=\"given-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field\">\r\n <label for=\"lastname\">Last name <span class=\"req\">*<\/span><\/label>\r\n <input id=\"lastname\" name=\"lastname\" type=\"text\" autocomplete=\"family-name\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"company\">Company <span class=\"req\">*<\/span><\/label>\r\n <input id=\"company\" name=\"company\" type=\"text\" autocomplete=\"organization\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"email\">Email <span class=\"req\">*<\/span><\/label>\r\n <input id=\"email\" name=\"email\" type=\"email\" autocomplete=\"email\" required>\r\n <\/div>\r\n\r\n <div class=\"field full\">\r\n <label for=\"case_selected\">Case study selected<\/label>\r\n <select id=\"case_selected\" name=\"case_selected\">\r\n <option value=\"\">Choisir <\/option>\r\n <option value=\"CS01\">CS01 \u2014 DDI Prediction Using Pre-Clinical Data Only<\/option>\r\n <option value=\"CS02\">CS02 \u2014 DDI Exploration for a drug with Complex Pharmacokinetics<\/option>\r\n <option value=\"CS03\">CS03 \u2014 Mechanism Identification of Complex DDI using Predictive PBPK Modeling<\/option>\r\n <option value=\"CS04\">CS04 \u2014 Network Interaction PBPK Modeling for Complex Victim-Perpetrator DDIs<\/option>\r\n <option value=\"CS05\">CS05 \u2014 PBPK Model Development and Comprehensive DDI Assessment of Oral Solution<\/option>\r\n <option value=\"CS06\">CS06 \u2014 PBPK Modeling using pre-clinical data for First-in-Human (FIH) translation<\/option>\r\n <option value=\"CS07\">CS07 \u2014 An iterative, Population PK approach to inform Dosing Strategy in Human African Trypanosomiasis (HAT)<\/option>\r\n<option value=\"CS08\">CS08 \u2014 Population PK Modeling to Inform Pediatric Dosing in Human African Trypanosomiasis (HAT) during Phase III development.<\/option>\r\n \r\n <\/select>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"checks\">\r\n <label class=\"check\">\r\n <input type=\"checkbox\" name=\"privacy\" value=\"1\" required>\r\n <span>\r\n I confirm that I have read and accept the\r\n <a href=\"\/en\/politique-de-confidentialite\/\" target=\"_blank\" rel=\"noopener\">privacy policy<\/a>\r\n de PhinC <span class=\"req\">*<\/span>\r\n <\/span>\r\n <\/label>\r\n\r\n <label class=\"check\">\r\n <input type=\"checkbox\" name=\"contact_optin\" value=\"1\">\r\n <span>I agree to be contacted by PhinC regarding its services.<\/span>\r\n <\/label>\r\n <\/div>\r\n\r\n <button class=\"btn btn-primary\" type=\"submit\" style=\"margin-top:24px;width:20%;\">\r\n Get the link\r\n <\/button>\r\n <\/form>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <script>\r\n (function(){\r\n \/\/ 1) Show thank-you message if sent=1\r\n const params = new URLSearchParams(window.location.search);\r\n if (params.get('sent') === '1') {\r\n const box = document.getElementById('successBox');\r\n if (box) box.style.display = 'block';\r\n }\r\n\r\n \/\/ 2) Pre-fill selected case when clicking a card CTA\r\n const select = document.getElementById('case_selected');\r\n const pdfInput = document.getElementById('pdf_link');\r\n const caseInput = document.getElementById('case_code');\r\n const downloadLinks = document.querySelectorAll('.phinc-download');\r\n\r\n downloadLinks.forEach(a => {\r\n a.addEventListener('click', () => {\r\n const code = a.getAttribute('data-case') || '';\r\n const pdf = a.getAttribute('data-pdf') || '';\r\n if (select && code) select.value = code;\r\n if (pdfInput) pdfInput.value = pdf;\r\n if (caseInput) caseInput.value = code;\r\n });\r\n });\r\n })();\r\n <\/script>\r\n\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Real projects, real impact \u2014 explore how PhinC’s modeling expertise has shaped drug development strategies across therapeutic areas and development stages.<\/p>","protected":false},"author":2,"featured_media":4548,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3980","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>Case studies - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/case-studies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Case studies - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"Real projects, real impact \u2014 explore how PhinC's modeling expertise has shaped drug development strategies across therapeutic areas and development stages.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/en\/case-studies\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC Group\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-30T08:40:19+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2024\/12\/cases-menu-thumbnail-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"400\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.phinc-group.com\\\/case-studies\\\/\",\"url\":\"https:\\\/\\\/www.phinc-group.com\\\/case-studies\\\/\",\"name\":\"Case studies - 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