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width:8px;height:8px;border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-blue), var(--phinc-pink));\r\n flex:0 0 auto;\r\n margin-top:7px;\r\n }\r\n\r\n \/* Case studies *\/\r\n .phinc-fih-lite .cases{\r\n display:grid; gap:16px;\r\n grid-template-columns: repeat(3, minmax(0,1fr));\r\n margin-top:16px;\r\n }\r\n .phinc-fih-lite .case{\r\n border-radius:22px;\r\n overflow:hidden;\r\n border:1px solid var(--line);\r\n background:#fff;\r\n box-shadow:0 18px 44px rgba(15,23,42,.10);\r\n display:flex;\r\n flex-direction:column;\r\n }\r\n .phinc-fih-lite .case .thumb{\r\n aspect-ratio: 16 \/ 10;\r\n border-bottom:1px solid var(--line);\r\n position:relative;\r\n overflow:hidden;\r\n background:#fff;\r\n }\r\n .phinc-fih-lite .case .thumb img{width:100%; height:100%; object-fit:cover;}\r\n .phinc-fih-lite .case .content{padding:16px;}\r\n .phinc-fih-lite .case p{color:var(--muted); margin-top:6px;}\r\n .phinc-fih-lite .case .cta{\r\n margin-top:auto;\r\n padding:0 16px 16px;\r\n }\r\n\r\n \/* Final CTA *\/\r\n .phinc-fih-lite .cta-band{\r\n background:\r\n radial-gradient(900px 420px at 10% 0%, rgba(217,75,159,.18), transparent 60%),\r\n radial-gradient(900px 420px at 90% 10%, rgba(0,0,95,.14), transparent 60%),\r\n linear-gradient(180deg, #ffffff 0%, var(--bg) 100%);\r\n border-top:1px solid var(--line);\r\n }\r\n .phinc-fih-lite .cta-box{\r\n background:#fff;\r\n border:1px solid var(--line);\r\n border-radius:26px;\r\n box-shadow:0 18px 44px rgba(15,23,42,.10);\r\n padding:22px;\r\n display:flex;\r\n flex-wrap:wrap;\r\n gap:14px;\r\n justify-content:space-between;\r\n align-items:center;\r\n }\r\n .phinc-fih-lite .cta-box h2{margin:0; font-size:clamp(22px, 2.6vw, 30px);}\r\n .phinc-fih-lite .cta-box p{margin:0; color:var(--muted); max-width:760px;}\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .phinc-fih-lite .split{grid-template-columns:1fr;}\r\n .phinc-fih-lite .feature-grid{grid-template-columns:1fr;}\r\n .phinc-fih-lite .cases{grid-template-columns:1fr;}\r\n }\r\n <\/style>\r\n\r\n \r\n <div class=\"hero\">\r\n <div class=\"wrap section\">\r\n <div class=\"split\">\r\n <div>\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> First-in-Human \u2022 PBPK \u2022 Modeling<\/span>\r\n <h2 class=\"translation-block\"><br>Safer FIH decisions, <br>powered by PBPK Modeling<\/h2>\r\n <p class=\"muted\">\r\n Starting dose, escalation, DDIs, variability: we turn your data into clear, actionable recommendations.\r\n <\/p>\r\n\r\n <div class=\"actions\">\r\n <a class=\"btn primary\" href=\"#contact\">\r\n Get in touch\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n <a class=\"btn secondary\" href=\"#case-studies\">See case studies<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"hero-card\" aria-label=\"Visuel First-in-Human\">\r\n <div class=\"hero-image\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/cover-fih-1000-x-670px.jpg\" alt=\"First-in-Human \u2013 PBPK & Mod\u00e9lisation\" loading=\"lazy\" \/>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"section\" id=\"pbpk\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> PBPK for FIH - Our approach<\/span>\r\n <h2>Build a robust FIH strategy thanks to PBPK Modeling<\/h2>\r\n <p class=\"muted\" style=\"max-width:880px;\">\r\n A lean, decision-driven approach: targeted simulations, explicit assumptions, and easy-to-use deliverables.\r\n <\/p>\r\n\r\n <div class=\"feature-grid\">\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M4 19h16v2H4v-2zm2-6h2v5H6v-5zm5-8h2v13h-2V5zm5 4h2v9h-2V9z\"\/><\/svg>\r\n <\/div>\r\n <h3>Dose & escalation<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>Define a robust starting dose (assumptions + safety margins).<\/li>\r\n <li><span class=\"b-dot\"><\/span>SAD\/MAD simulations for safer, more efficient dose escalation.<\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M12 2a7 7 0 017 7c0 2.1-.9 4-2.4 5.4l2.3 5.6h-2.2l-1.7-4.1c-.6.2-1.3.3-2 .3a7 7 0 110-14zm0 2a5 5 0 100 10 5 5 0 000-10z\"\/><\/svg>\r\n <\/div>\r\n <h3>DDI & variability<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>Anticipate the impact of inhibitors\/inducers (CYP\/transporters) on exposure.<\/li>\r\n <li><span class=\"b-dot\"><\/span>Test \u201cworst-case\u201d scenarios and quantify uncertainty.<\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M7 2h10v2H7V2zM5 6h14v16H5V6zm2 2v12h10V8H7z\"\/><\/svg>\r\n <\/div>\r\n <h3>Submission-ready report<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>Results, figures, and structured assumptions ready for protocol and dossier.<\/li>\r\n <li><span class=\"b-dot\"><\/span>Align clinical, non-clinical, and regulatory teams around shared key messages.<\/li>\r\n <\/ul>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"section\" id=\"case-studies\" style=\"background:var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line);\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> Case studies<\/span>\r\n\r\n <div class=\"cases\">\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Pharmacokinetic prediction using pre-clinical data to develop a PBPK model for FIH translation<\/h3>\r\n <p>The sponsor requested the development of a complete PBPK model incorporating preclinical data, in order to build a PBPK framework for FIH transposition.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/#pbpk-case-studies\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"cta-band section tight\" id=\"contact\">\r\n <div class=\"wrap\">\r\n <div class=\"cta-box\">\r\n <div>\r\n <h2>A FIH strategy supported by solid quantitative analyses<\/h2>\r\n <p>Clear, defensible recommendations focused on your next decision.<\/p>\r\n <\/div>\r\n <div class=\"actions\" style=\"margin-top:50;\">\r\n <a class=\"btn primary\" href=\"\/en\/contact\/\">\r\n Get in touch\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/#pbpk-case-studies\">\r\n See case studies\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n \r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <script>\r\n document.getElementById(\"y\") && (document.getElementById(\"y\").textContent = new Date().getFullYear());\r\n <\/script>\r\n<\/section>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>PhinC leverages advanced PK modeling to define safe and informed starting doses for your first-in-human studies.<\/p>","protected":false},"author":2,"featured_media":3909,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3795","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>1ere administration (FiH) - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/fih\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"1ere administration (FiH) - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"PhinC leverages advanced PK modeling to define safe and informed starting doses for your first-in-human studies.\" \/>\n<meta property=\"og:url\" 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width:8px;height:8px;border-radius:999px;\r\n background:linear-gradient(135deg, var(--phinc-blue), var(--phinc-pink));\r\n flex:0 0 auto;\r\n margin-top:7px;\r\n }\r\n\r\n \/* Case studies *\/\r\n .phinc-fih-lite .cases{\r\n display:grid; gap:16px;\r\n grid-template-columns: repeat(3, minmax(0,1fr));\r\n margin-top:16px;\r\n }\r\n .phinc-fih-lite .case{\r\n border-radius:22px;\r\n overflow:hidden;\r\n border:1px solid var(--line);\r\n background:#fff;\r\n box-shadow:0 18px 44px rgba(15,23,42,.10);\r\n display:flex;\r\n flex-direction:column;\r\n }\r\n .phinc-fih-lite .case .thumb{\r\n aspect-ratio: 16 \/ 10;\r\n border-bottom:1px solid var(--line);\r\n position:relative;\r\n overflow:hidden;\r\n background:#fff;\r\n }\r\n .phinc-fih-lite .case .thumb img{width:100%; height:100%; object-fit:cover;}\r\n .phinc-fih-lite .case .content{padding:16px;}\r\n .phinc-fih-lite .case p{color:var(--muted); margin-top:6px;}\r\n .phinc-fih-lite .case .cta{\r\n margin-top:auto;\r\n padding:0 16px 16px;\r\n }\r\n\r\n \/* Final CTA *\/\r\n .phinc-fih-lite .cta-band{\r\n background:\r\n radial-gradient(900px 420px at 10% 0%, rgba(217,75,159,.18), transparent 60%),\r\n radial-gradient(900px 420px at 90% 10%, rgba(0,0,95,.14), transparent 60%),\r\n linear-gradient(180deg, #ffffff 0%, var(--bg) 100%);\r\n border-top:1px solid var(--line);\r\n }\r\n .phinc-fih-lite .cta-box{\r\n background:#fff;\r\n border:1px solid var(--line);\r\n border-radius:26px;\r\n box-shadow:0 18px 44px rgba(15,23,42,.10);\r\n padding:22px;\r\n display:flex;\r\n flex-wrap:wrap;\r\n gap:14px;\r\n justify-content:space-between;\r\n align-items:center;\r\n }\r\n .phinc-fih-lite .cta-box h2{margin:0; font-size:clamp(22px, 2.6vw, 30px);}\r\n .phinc-fih-lite .cta-box p{margin:0; color:var(--muted); max-width:760px;}\r\n\r\n \/* Responsive *\/\r\n @media (max-width: 980px){\r\n .phinc-fih-lite .split{grid-template-columns:1fr;}\r\n .phinc-fih-lite .feature-grid{grid-template-columns:1fr;}\r\n .phinc-fih-lite .cases{grid-template-columns:1fr;}\r\n }\r\n <\/style>\r\n\r\n \r\n <div class=\"hero\">\r\n <div class=\"wrap section\">\r\n <div class=\"split\">\r\n <div>\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> First-in-Human \u2022 PBPK \u2022 Modeling<\/span>\r\n <h2 class=\"translation-block\"><br>Safer FIH decisions, <br>powered by PBPK Modeling<\/h2>\r\n <p class=\"muted\">\r\n Starting dose, escalation, DDIs, variability: we turn your data into clear, actionable recommendations.\r\n <\/p>\r\n\r\n <div class=\"actions\">\r\n <a class=\"btn primary\" href=\"#contact\">\r\n Get in touch\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n <a class=\"btn secondary\" href=\"#case-studies\">See case studies<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"hero-card\" aria-label=\"Visuel First-in-Human\">\r\n <div class=\"hero-image\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/cover-fih-1000-x-670px.jpg\" alt=\"First-in-Human \u2013 PBPK & Mod\u00e9lisation\" loading=\"lazy\" \/>\r\n <\/div>\r\n <\/div>\r\n\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"section\" id=\"pbpk\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> PBPK for FIH - Our approach<\/span>\r\n <h2>Build a robust FIH strategy thanks to PBPK Modeling<\/h2>\r\n <p class=\"muted\" style=\"max-width:880px;\">\r\n A lean, decision-driven approach: targeted simulations, explicit assumptions, and easy-to-use deliverables.\r\n <\/p>\r\n\r\n <div class=\"feature-grid\">\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M4 19h16v2H4v-2zm2-6h2v5H6v-5zm5-8h2v13h-2V5zm5 4h2v9h-2V9z\"\/><\/svg>\r\n <\/div>\r\n <h3>Dose & escalation<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>Define a robust starting dose (assumptions + safety margins).<\/li>\r\n <li><span class=\"b-dot\"><\/span>SAD\/MAD simulations for safer, more efficient dose escalation.<\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M12 2a7 7 0 017 7c0 2.1-.9 4-2.4 5.4l2.3 5.6h-2.2l-1.7-4.1c-.6.2-1.3.3-2 .3a7 7 0 110-14zm0 2a5 5 0 100 10 5 5 0 000-10z\"\/><\/svg>\r\n <\/div>\r\n <h3>DDI & variability<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>Anticipate the impact of inhibitors\/inducers (CYP\/transporters) on exposure.<\/li>\r\n <li><span class=\"b-dot\"><\/span>Test \u201cworst-case\u201d scenarios and quantify uncertainty.<\/li>\r\n <\/ul>\r\n <\/div>\r\n\r\n <div class=\"feature\">\r\n <div class=\"icon\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M7 2h10v2H7V2zM5 6h14v16H5V6zm2 2v12h10V8H7z\"\/><\/svg>\r\n <\/div>\r\n <h3>Submission-ready report<\/h3>\r\n <ul class=\"bullets\">\r\n <li><span class=\"b-dot\"><\/span>Results, figures, and structured assumptions ready for protocol and dossier.<\/li>\r\n <li><span class=\"b-dot\"><\/span>Align clinical, non-clinical, and regulatory teams around shared key messages.<\/li>\r\n <\/ul>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"section\" id=\"case-studies\" style=\"background:var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line);\">\r\n <div class=\"wrap\">\r\n <span class=\"eyebrow\"><span class=\"dot\"><\/span> Case studies<\/span>\r\n\r\n <div class=\"cases\">\r\n <article class=\"case\">\r\n <div class=\"thumb\">\r\n <img decoding=\"async\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/02\/case-studies-cover-600x400-1.jpg\" alt=\"Case study 1\" loading=\"lazy\" \/>\r\n <\/div>\r\n <div class=\"content\">\r\n <h3>Pharmacokinetic prediction using pre-clinical data to develop a PBPK model for FIH translation<\/h3>\r\n <p>The sponsor requested the development of a complete PBPK model incorporating preclinical data, in order to build a PBPK framework for FIH transposition.<\/p>\r\n <\/div>\r\n <div class=\"cta\">\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/#pbpk-case-studies\">See case study<\/a>\r\n <\/div>\r\n <\/article>\r\n\r\n \r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n \r\n <div class=\"cta-band section tight\" id=\"contact\">\r\n <div class=\"wrap\">\r\n <div class=\"cta-box\">\r\n <div>\r\n <h2>A FIH strategy supported by solid quantitative analyses<\/h2>\r\n <p>Clear, defensible recommendations focused on your next decision.<\/p>\r\n <\/div>\r\n <div class=\"actions\" style=\"margin-top:50;\">\r\n <a class=\"btn primary\" href=\"\/en\/contact\/\">\r\n Get in touch\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n <a class=\"btn secondary\" href=\"\/en\/case-studies\/#pbpk-case-studies\">\r\n See case studies\r\n <span class=\"arrow\" aria-hidden=\"true\">\r\n <svg viewbox=\"0 0 24 24\"><path d=\"M13.5 5l7 7-7 7-1.4-1.4 4.6-4.6H4v-2h12.7l-4.6-4.6L13.5 5z\"\/><\/svg>\r\n <\/span>\r\n <\/a>\r\n \r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n\r\n <script>\r\n document.getElementById(\"y\") && (document.getElementById(\"y\").textContent = new Date().getFullYear());\r\n <\/script>\r\n<\/section>\r\n<\/body>\r\n<\/html>\r\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>PhinC leverages advanced PK modeling to define safe and informed starting doses for your first-in-human studies.<\/p>","protected":false},"author":2,"featured_media":3909,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3795","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>1ere administration (FiH) - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/fih\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"1ere administration (FiH) - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"PhinC leverages advanced PK modeling to define safe and informed starting doses for your first-in-human studies.\" \/>\n<meta property=\"og:url\" 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