PhinC \u2013 Offre MIDD (Preview)<\/title>\r\n<\/head>\r\n<body style=\"margin:0;background:#ffffff;\">\r\n<section class=\"phinc-midd\">\r\n\r\n <style>\r\n :root{\r\n --phinc-blue:#00005f;\r\n --phinc-pink:#D94B9F;\r\n --ink:#0F172A;\r\n --muted:#475569;\r\n --line:#E6EAF2;\r\n --bg:#F7F9FC;\r\n --card:#FFFFFF;\r\n --radius:18px;\r\n --shadow: 0 10px 30px rgba(15, 23, 42, .08);\r\n --max:1120px;\r\n }\r\n\r\n .phinc-midd{\r\n font-family: inherit; \/* Inter via Elementor *\/\r\n color:var(--ink);\r\n }\r\n\r\n .phinc-wrap{ max-width:var(--max); margin:0 auto; padding:72px 20px; }\r\n .phinc-eyebrow{\r\n display:inline-flex; gap:10px; align-items:center;\r\n padding:8px 12px; border:1px solid var(--line); border-radius:999px;\r\n color:var(--muted); background:#fff; font-size:13px; font-weight:400;\r\n }\r\n .phinc-dot{\r\n width:10px; height:10px; border-radius:999px;\r\n background: var(--phinc-blue); \/* full bleu *\/\r\n display:inline-block;\r\n }\r\n\r\n .phinc-h1{\r\n 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solid var(--line);\r\n border-radius: var(--radius);\r\n background: rgba(255,255,255,.65);\r\n padding:16px;\r\n }\r\n\r\n .phinc-list{ margin:0; padding:0; list-style:none; display:grid; gap:10px; }\r\n .phinc-list li{\r\n display:flex; gap:10px; align-items:flex-start;\r\n color:var(--muted); font-size:14px; line-height:1.45; font-weight:300;\r\n }\r\n .phinc-check{\r\n width:18px; height:18px; border-radius:6px;\r\n background: linear-gradient(135deg, var(--phinc-blue), var(--phinc-pink));\r\n flex: 0 0 auto; margin-top:2px;\r\n }\r\n\r\n \/* ====== Regulatory endorsement (Certara-like) ====== *\/\r\n .phinc-endorse{ text-align:center; }\r\n .phinc-endorse .phinc-p{ max-width: 920px; margin: 0 auto; }\r\n .phinc-endorse-grid{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:28px;\r\n }\r\n .phinc-endorse-card{\r\n background: var(--card);\r\n border:1px solid var(--line);\r\n border-radius: var(--radius);\r\n padding:22px 18px;\r\n 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16\/9;\r\n border-radius: 14px;\r\n border:1px solid var(--line);\r\n background: linear-gradient(135deg, rgba(0,0,95,.10), rgba(217,75,159,.10));\r\n margin-bottom:2px;\r\n background-size: cover;\r\n background-position: center;\r\n background-repeat: no-repeat;\r\n }\r\n .phinc-cs-top{\r\n display:flex;\r\n justify-content:space-between;\r\n align-items:center;\r\n gap:10px;\r\n }\r\n .phinc-cs-pill{\r\n font-size:12px;\r\n padding:6px 10px;\r\n border:1px solid var(--line);\r\n border-radius:999px;\r\n background:#fff;\r\n color:var(--muted);\r\n font-weight:400;\r\n white-space:nowrap;\r\n }\r\n .phinc-cs-card h3{\r\n margin:0;\r\n font-size:16px;\r\n font-weight:700;\r\n letter-spacing:-.01em;\r\n line-height:1.25;\r\n }\r\n .phinc-cs-lines{\r\n display:grid;\r\n gap:8px;\r\n margin:0;\r\n padding:0;\r\n list-style:none;\r\n }\r\n .phinc-cs-lines li{\r\n display:flex;\r\n gap:10px;\r\n align-items:flex-start;\r\n color:var(--muted);\r\n font-size:14px;\r\n line-height:1.45;\r\n 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font-weight: 400;\r\n white-space: nowrap;\r\n transition: transform .16s ease, box-shadow .16s ease, border-color .16s ease;\r\n }\r\n .phinc-side a .phinc-side-dot{\r\n width: 10px; height: 10px; border-radius: 999px;\r\n border: 2px solid var(--phinc-blue);\r\n background: #fff;\r\n flex: 0 0 auto;\r\n }\r\n .phinc-side a:hover{\r\n transform: scale(1.06);\r\n box-shadow: 0 12px 30px rgba(15,23,42,.12);\r\n border-color: rgba(0,0,95,.22);\r\n }\r\n\r\n \/* Optional: active state (JS will toggle) *\/\r\n .phinc-side a.is-active{\r\n border-color: rgba(0,0,95,.35);\r\n box-shadow: 0 12px 30px rgba(15,23,42,.14);\r\n }\r\n .phinc-side a.is-active .phinc-side-dot{\r\n background: var(--phinc-blue);\r\n }\r\n\r\n \/* Hide side menu on small screens *\/\r\n @media (max-width: 980px){\r\n .phinc-side{ display:none; }\r\n }\r\n\r\n @media (max-width: 920px){\r\n .phinc-hero-grid, .phinc-split, .phinc-cta{ grid-template-columns: 1fr; }\r\n .phinc-split.reverse .phinc-split-media{ order: 0; }\r\n .phinc-cards, .phinc-steps-grid, .phinc-proof{ grid-template-columns: 1fr; }\r\n .phinc-endorse-grid{ grid-template-columns: 1fr; }\r\n .phinc-cs-grid{ grid-template-columns: 1fr; }\r\n .phinc-h1{ font-size:36px; }\r\n }\r\n <\/style>\r\n\r\n \r\n <nav class=\"phinc-side\" aria-label=\"Navigation rapide MIDD\">\r\n <a href=\"#top\" data-target=\"#top\"><span class=\"phinc-side-dot\"><\/span>MIDD Offer<\/a>\r\n <a href=\"#deliverables\" data-target=\"#deliverables\"><span class=\"phinc-side-dot\"><\/span>Benefits<\/a>\r\n <a href=\"#regulatory-endorsement\" data-target=\"#regulatory-endorsement\"><span class=\"phinc-side-dot\"><\/span>Regulatory acceptance<\/a>\r\n <a href=\"#roadmap\" data-target=\"#roadmap\"><span class=\"phinc-side-dot\"><\/span>Roadmap<\/a>\r\n <a href=\"#modules\" data-target=\"#modules\"><span class=\"phinc-side-dot\"><\/span>Custom solutions<\/a>\r\n <\/nav>\r\n\r\n <header class=\"phinc-hero\" id=\"top\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-hero-grid\">\r\n <div>\r\n <div class=\"phinc-eyebrow\"><span class=\"phinc-dot\"><\/span> <b>Complete MIDD offer - from lead optimization to registration<\/b><\/div>\r\n <h2 class=\"phinc-h2\">Optimize your development with a clear and traceable MIDD strategy.<\/h2>\r\n <p class=\"phinc-sub\">\r\n Through integrated quantitative approach applied from the earliest stages of drug development, MIDD (Model-Informed Drug Development) enables the generation of robust predictive models to inform decision-making and guide development through Phase III.\r\n <\/p>\r\n\r\n <div class=\"phinc-actions\">\r\n <a class=\"phinc-btn primary\" href=\"#contact\">Get in touch<\/a>\r\n <a class=\"phinc-btn\" href=\"#roadmap\">See the MIDD roadmap<\/a>\r\n <\/div>\r\n\r\n <div class=\"phinc-badges\">\r\n <span class=\"phinc-badge\">PK\/PD - PopPK<\/span>\r\n <span class=\"phinc-badge\">PBPK<\/span>\r\n <span class=\"phinc-badge\">QSP<\/span>\r\n <span class=\"phinc-badge\">Clinical Trial Simulation<\/span>\r\n <span class=\"phinc-badge\">NCA-CDISC<\/span>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-hero-card\">\r\n <div class=\"phinc-visual\" aria-label=\"Visuel MIDD\"><\/div>\r\n <p class=\"phinc-p\" style=\"margin-top:14px;\">\r\n Our experts support you from the earliest development stages through regulatory submission.\r\n <\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/header>\r\n\r\n <section class=\"phinc-section\" id=\"deliverables\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-kicker\">What you earn<\/div>\r\n <h2 class=\"phinc-h2\">Evidence\u2011based decision\u2011making and a well-justified dose.<\/h2>\r\n\r\n <div class=\"phinc-cards\">\r\n <div class=\"phinc-card\">\r\n <h3>Informed strategic decisions<\/h3>\r\n <p>Anticipate outcomes and reduce risk at key stages of development.<\/p>\r\n <div class=\"phinc-mini\"><span>go\/no-go<\/span><span>prioritization<\/span><span>time-to-PoC<\/span><\/div>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Smarter clinical trials<\/h3>\r\n <p>Reduce the number of cohorts, optimize dosing regimens, and shorten timelines.<\/p>\r\n <div class=\"phinc-mini\"><span>FIH<\/span><span>escalation<\/span><span>populations<\/span><\/div>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Strengthened regulatory dialogue<\/h3>\r\n <p>Support your decisions with transparent, model-based evidence.<\/p>\r\n <div class=\"phinc-mini\"><span>dose justification<\/span><span>Q&A authorities<\/span><\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section alt\" id=\"regulatory-endorsement\">\r\n <div class=\"phinc-wrap phinc-endorse\">\r\n <div class=\"phinc-kicker\">Regulatory acceptance<\/div>\r\n <h2 class=\"phinc-h2\">MIDD is supported by regulatory agencies.<\/h2>\r\n <p class=\"phinc-p\">\r\n Regulatory agencies increasingly value MIDD Strategy to improve development efficiency, strengthen dose justification, and support robust decision-making.\r\n <\/p>\r\n\r\n <div class=\"phinc-endorse-grid\">\r\n <div class=\"phinc-endorse-card\">\r\n <h3>\r\n <a href=\"https:\/\/www.fda.gov\/drugs\/development-resources\/model-informed-drug-development-paired-meeting-program\"\r\n target=\"_blank\" rel=\"noopener noreferrer\">\r\n \ud83c\uddfa\ud83c\uddf8 FDA Paired Meeting\r\n <\/a>\r\n <\/h3>\r\n <p>\r\n FDA Paired Meetings enable early alignment of modeling strategies with the agency expectations, helping to secure key decisions and de-risking future submissions.\r\n <\/p>\r\n <\/div>\r\n\r\n <div class=\"phinc-endorse-card\">\r\n <h3>\r\n <a href=\"https:\/\/database.ich.org\/sites\/default\/files\/ICH_M15_Step4_Final_Guideline_2026_0129.pdf\"\r\n target=\"_blank\" rel=\"noopener noreferrer\">\r\n \ud83d\udcd8 ICH M15 \u2013 Guideline MIDD\r\n <\/a>\r\n <\/h3>\r\n <p>\r\n The ICH M15 guideline formalizes the principles of Model-Informed Drug Development and recognizes its central role in development decision-making.\r\n <\/p>\r\n <\/div>\r\n\r\n <div class=\"phinc-endorse-card\">\r\n <h3>\r\n <a href=\"https:\/\/www.ema.europa.eu\/en\/guideline-assessment-reporting-mechanistic-models-used-context-model-informed-drug-development\"\r\n target=\"_blank\" rel=\"noopener noreferrer\">\r\n \ud83c\uddea\ud83c\uddfa EMA & mechanistic models\r\n <\/a>\r\n <\/h3>\r\n <p>\r\n The EMA highlights the value of mechanistic models to strengthen assessment, interpretation, and the robustness of decisions within a MIDD framework.\r\n <\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section alt\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-split\">\r\n <div class=\"phinc-split-media\" aria-label=\"Visuel\"><\/div>\r\n <div>\r\n <div class=\"phinc-kicker\">Approach<\/div>\r\n <h2 class=\"phinc-h2 translation-block\">A comprehensive MIDD strategy,<br>designed to guide your key decisions.<\/h2>\r\n <p class=\"phinc-p\">\r\n From hypothesis definition to final recommendation, we combine modeling, simulation, and regulatory expertise to deliver clear, actionable outputs directly usable by your non-clinical, clinical, and regulatory teams.\r\n <\/p>\r\n <div class=\"phinc-actions\">\r\n <a class=\"phinc-btn primary\" href=\"#roadmap\">Build my development strategy<\/a>\r\n <a class=\"phinc-btn\" href=\"#modules\">Explore modules<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section\" id=\"roadmap\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-kicker\">MIDD Roadmap<\/div>\r\n <h2 class=\"phinc-h2\">From lead optimization to filing<\/h2>\r\n\r\n <div class=\"phinc-steps\">\r\n <div class=\"phinc-steps-grid\">\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Lead Optimization<\/span>\r\n <\/div>\r\n <p>Speed up candidate and target profile selection. PhinC helps you prioritize options through a mechanistic modeling.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s1\"><span>\u2192<\/span> Discuss framing<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Preclinical<\/span>\r\n <\/div>\r\n <p>Anticipate translation to humans. PhinC helps you secure exposure, starting dose and key assumptions.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s2\"><span>\u2192<\/span> See PBPK \/ PKPD<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Phase I<\/span>\r\n <\/div>\r\n <p>Secure first administration and escalation. PhinC helps you control PK, tolerance and cohort design.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s3\"><span>\u2192<\/span> Optimizing a FIH<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Phase II<\/span>\r\n <\/div>\r\n <p>Accelerate patient proof-of-concept.<\/p>\r\n <p>PhinC helps you optimize the dose-exposure-response relationship for dose selection.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s4\"><span>\u2192<\/span> CTS & PoC<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Phase III<\/span>\r\n <\/div>\r\n <p>Confirm your dosing strategy. PhinC helps you anticipate variability and strengthen the robustness of your results.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s5\"><span>\u2192<\/span> De-risk my Phase III study<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Filing<\/span>\r\n <\/div>\r\n <p>Turn your data into a regulatory argument. PhinC helps you justify dose and regimen with a clear, traceable narrative.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s6\"><span>\u2192<\/span> Regulatory Support<\/a>\r\n <\/article>\r\n\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section alt\" id=\"modules\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-split reverse\">\r\n <div>\r\n <div class=\"phinc-kicker\">OUR CUSTOM SOLUTIONS<\/div>\r\n <h2 class=\"phinc-h2\">Tailored approaches, adapted to every development challenge.<\/h2>\r\n <p class=\"phinc-p\">\r\n One objective, one deliverable: from a fast, targeted answer to a full mechanistic model.\nWe tailor the level of complexity to the maturity of your data.\r\n <\/p><br>\r\n <div class=\"phinc-actions\">\r\n <a class=\"phinc-btn primary\" href=\"\/en\/contact\/\">Get in touch<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-cards\" style=\"margin-top:0;\">\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/service\/pbpk\/\">PBPK - PBBM<\/a><\/h3><p>Extrapolate across species, routes, and populations when data are limited.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/qsp\/\">QSP<\/a><\/h3>\r\n <p>Make fast, consistent, data-driven decisions aligned with clinical objectives.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/poppk-pd\/\">PopPK \/ PK-PD<\/a><\/h3>\r\n <p>Understand systemic exposure and quantify variability to guide dosing.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/service\/qt-qtc\/\">QT\/QTc Analysis<\/a><\/h3>\r\n <p>Provides robust, critical predictions to assess the risk of QTc prolongation.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/service\/pknca\/\">PK NCA CDISC<\/a><\/h3>\r\n <p>Ensures robust, fully compliant analyses for regulatory submission.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/clinical-trial-simulation\/\">CTS<\/a><\/h3>\r\n <p>Structures the clinical strategy and secures key development decisions.<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section\" id=\"proof\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-kicker\">Delivrables<\/div>\r\n <h2 class=\"phinc-h2\">Predictive models to de-risk drug exposure-response<\/h2>\r\n <p class=\"phinc-p\">Concrete recommendations and justification models.<\/p>\r\n\r\n <div class=\"phinc-proof\">\r\n <div class=\"phinc-card\">\r\n <h3>Dose recommendations<\/h3>\r\n <p>Proposed dose(s) and regimen, with defined confidence levels and safety margins.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Scenarios simulation<\/h3>\r\n <p>Test trial scenarios to optimize doses, sample sizes, and endpoints.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Regulatory Support<\/h3>\r\n <p>Support development decisions in discussions with health authorities.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-cta\" id=\"contact\">\r\n <div>\r\n <h3>Let's build your MIDD roadmap<\/h3>\r\n <p class=\"translation-block\">Share your development stage, available data, and next target. <br>We will propose a clear strategy, timeline, and deliverables.<\/p>\r\n <div class=\"phinc-actions\" style=\"margin-top:16px;\">\r\n <a class=\"phinc-btn primary\" href=\"\/en\/contact\/\">Get in touch<\/a>\r\n <\/div>\r\n <\/div>\r\n <div class=\"phinc-cta phinc-slim\" style=\"margin-top:0; box-shadow:none;\">\r\n <ul class=\"phinc-list\">\r\n <li><span class=\"phinc-check\"><\/span>Objective & expected decisions<\/li>\r\n <li><span class=\"phinc-check\"><\/span>Mandatory data (minimum viable)<\/li>\r\n <li><span class=\"phinc-check\"><\/span>Delivrables & timelines<\/li>\r\n <li><span class=\"phinc-check\"><\/span>Support for regulatory submission<\/li>\r\n <\/ul>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <script>\r\n \/\/ Smooth scroll for side menu + active section highlight\r\n (function(){\r\n const menuLinks = Array.from(document.querySelectorAll('.phinc-side a'));\r\n const targets = menuLinks\r\n .map(a => document.querySelector(a.getAttribute('href')))\r\n .filter(Boolean);\r\n\r\n \/\/ Smooth scrolling (works in modern browsers via CSS, but safe fallback)\r\n menuLinks.forEach(a => {\r\n a.addEventListener('click', (e) => {\r\n const id = a.getAttribute('href');\r\n const el = document.querySelector(id);\r\n if(!el) return;\r\n e.preventDefault();\r\n el.scrollIntoView({ behavior: 'smooth', block: 'start' });\r\n });\r\n });\r\n\r\n \/\/ Active state with IntersectionObserver\r\n if('IntersectionObserver' in window && targets.length){\r\n const obs = new IntersectionObserver((entries) => {\r\n entries.forEach(entry => {\r\n if(!entry.isIntersecting) return;\r\n const id = '#' + entry.target.id;\r\n menuLinks.forEach(a => a.classList.toggle('is-active', a.getAttribute('href') === id));\r\n });\r\n }, { root: null, threshold: 0.35 });\r\n targets.forEach(t => obs.observe(t));\r\n }\r\n })();\r\n <\/script>\r\n\r\n<\/section>\r\n<\/body>\r\n<\/html>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>PhinC places modeling and simulation at the heart of your development decisions \u2014 turning data into actionable insights that accelerate timelines and reduce attrition.<\/p>","protected":false},"author":2,"featured_media":3345,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3483","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>La strat\u00e9gie MIDD - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/midd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La strat\u00e9gie MIDD - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"PhinC places modeling and simulation at the heart of your development decisions \u2014 turning data into actionable insights that accelerate timelines and reduce attrition.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/en\/midd\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC Group\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-30T08:45:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/ChatGPT-Image-16-janv.-2026-10_02_20-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1536\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.phinc-group.com\/midd\/\",\"url\":\"https:\/\/www.phinc-group.com\/midd\/\",\"name\":\"La strat\u00e9gie MIDD - 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}\r\n\r\n .phinc-h1{\r\n font-size:46px; line-height:1.05; letter-spacing:-.02em;\r\n margin:14px 0 12px; font-weight:700;\r\n }\r\n .phinc-sub{\r\n font-size:18px; color:var(--muted); max-width:760px;\r\n line-height:1.55; margin:0 0 26px; font-weight:300;\r\n }\r\n\r\n .phinc-list li{ white-space: nowrap; }\r\n\r\n .phinc-actions{ display:flex; flex-wrap:wrap; gap:12px; margin-top:18px; }\r\n .phinc-btn{\r\n display:inline-flex; align-items:center; justify-content:center; gap:10px;\r\n padding:14px 16px; border-radius:12px; text-decoration:none;\r\n font-weight:700; font-size:14px;\r\n border:1px solid var(--line); background:#fff; color:var(--ink);\r\n transition: transform .12s ease, box-shadow .12s ease;\r\n cursor:pointer;\r\n }\r\n .phinc-btn:hover{ transform: translateY(-1px); box-shadow: var(--shadow); }\r\n .phinc-btn.primary{\r\n border:none; color:#fff;\r\n background: linear-gradient(135deg, var(--phinc-pink));\r\n }\r\n\r\n .phinc-btn.neutral{\r\n background:#fff;\r\n 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url(\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/MIDD-cover-smiling-woman-800px.jpg\") center\/cover no-repeat;\r\n position:relative; overflow:hidden;\r\n }\r\n\r\n .phinc-badges{ display:flex; flex-wrap:wrap; gap:10px; margin-top:14px; }\r\n .phinc-badge{\r\n font-size:12px; color:var(--muted);\r\n padding:8px 10px; border:1px solid var(--line); border-radius:999px;\r\n background:#fff; font-weight:400;\r\n }\r\n\r\n .phinc-section{ background:#fff; }\r\n .phinc-section.alt{ background: var(--bg); border-top:1px solid var(--line); border-bottom:1px solid var(--line); }\r\n\r\n .phinc-kicker{\r\n font-weight:700; font-size:12px; letter-spacing:.14em; text-transform:uppercase;\r\n color: var(--muted); margin-bottom:10px;\r\n }\r\n .phinc-h2{\r\n font-size:32px; letter-spacing:-.02em; margin:0 0 10px; line-height:1.15; font-weight:700;\r\n padding-top:20px;\r\n padding-bottom:15px;\r\n }\r\n .phinc-p{ margin:0; color:var(--muted); font-size:16px; line-height:1.6; font-weight:300; }\r\n\r\n .phinc-split{ display:grid; grid-template-columns: 1fr 1fr; gap:26px; align-items:center; }\r\n .phinc-split.reverse .phinc-split-media{ order: -1; }\r\n\r\n .phinc-split-media{\r\n width:100%; aspect-ratio: 16\/10; border-radius: var(--radius);\r\n border:1px solid var(--line);\r\n background: url(\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/ChatGPT-Image-16-janv.-2026-10_02_20-1.png\") center\/cover no-repeat;\r\n box-shadow: var(--shadow);\r\n }\r\n\r\n .phinc-cards{ display:grid; grid-template-columns: repeat(3, 1fr); gap:16px; margin-top:22px; }\r\n .phinc-card{\r\n background:var(--card); border:1px solid var(--line); border-radius: var(--radius);\r\n padding:18px; box-shadow: 0 6px 20px rgba(15,23,42,.05);\r\n }\r\n .phinc-card h3{ margin:0 0 8px; font-size:16px; letter-spacing:-.01em; font-weight:700; }\r\n .phinc-card p{ margin:0; color:var(--muted); font-size:14px; line-height:1.55; font-weight:300; }\r\n .phinc-card .phinc-mini{ margin-top:12px; display:flex; gap:10px; flex-wrap:wrap; }\r\n .phinc-mini span{\r\n font-size:12px; color:var(--muted); border:1px solid var(--line);\r\n padding:6px 8px; border-radius:999px; background:#fff; font-weight:400;\r\n }\r\n\r\n .phinc-steps{ margin-top:26px; }\r\n .phinc-steps-grid{ display:grid; grid-template-columns: repeat(3, 1fr); gap:16px; }\r\n\r\n .phinc-step{\r\n background: transparent;\r\n border:1px solid var(--line);\r\n border-radius: var(--radius);\r\n padding:18px;\r\n position:relative;\r\n box-shadow: none;\r\n }\r\n\r\n .phinc-step-top{ display:flex; justify-content:space-between; align-items:center; gap:10px; margin-bottom:10px; }\r\n .phinc-num{\r\n font-weight:700; font-size:16px; color:#fff; padding:3px 8px; border-radius:999px;\r\n background: var(--phinc-blue); \/* full bleu *\/\r\n }\r\n .phinc-stage{ font-weight:700; font-size:14px; }\r\n .phinc-step p{ margin:0; color:var(--muted); font-size:14px; line-height:1.55; font-weight:300; }\r\n .phinc-step p strong{ font-weight:700; color:var(--ink); }\r\n\r\n .phinc-link{\r\n margin-top:12px; display:inline-flex; gap:8px; align-items:center;\r\n text-decoration:none; font-weight:700; color: var(--ink); font-size:13px;\r\n }\r\n .phinc-link span{ color: var(--phinc-blue); }\r\n\r\n .phinc-proof{ display:grid; grid-template-columns: 1fr 1fr 1fr; gap:16px; margin-top:24px; }\r\n .phinc-proof .phinc-card{ padding:20px; }\r\n\r\n .phinc-cta{\r\n background: linear-gradient(135deg, rgba(0,0,95,.10), rgba(217,75,159,.10));\r\n border:1px solid var(--line);\r\n border-radius: calc(var(--radius) + 6px);\r\n padding:26px;\r\n display:grid; grid-template-columns: 1.2fr .8fr; gap:18px; align-items:center;\r\n box-shadow: var(--shadow);\r\n margin-top:26px;\r\n }\r\n .phinc-cta h3{ margin:0 0 8px; font-size:22px; letter-spacing:-.01em; font-weight:700; }\r\n .phinc-cta p{ margin:0; color:var(--muted); line-height:1.6; font-weight:300; }\r\n\r\n .phinc-cta .phinc-slim{\r\n border:1px solid var(--line);\r\n border-radius: var(--radius);\r\n background: rgba(255,255,255,.65);\r\n padding:16px;\r\n }\r\n\r\n .phinc-list{ margin:0; padding:0; list-style:none; display:grid; gap:10px; }\r\n .phinc-list li{\r\n display:flex; gap:10px; align-items:flex-start;\r\n color:var(--muted); font-size:14px; line-height:1.45; font-weight:300;\r\n }\r\n .phinc-check{\r\n width:18px; height:18px; border-radius:6px;\r\n background: linear-gradient(135deg, var(--phinc-blue), var(--phinc-pink));\r\n flex: 0 0 auto; margin-top:2px;\r\n }\r\n\r\n \/* ====== Regulatory endorsement (Certara-like) ====== *\/\r\n .phinc-endorse{ text-align:center; }\r\n .phinc-endorse .phinc-p{ max-width: 920px; margin: 0 auto; }\r\n .phinc-endorse-grid{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:28px;\r\n }\r\n .phinc-endorse-card{\r\n background: var(--card);\r\n border:1px solid var(--line);\r\n border-radius: var(--radius);\r\n padding:22px 18px;\r\n box-shadow: 0 6px 20px rgba(15,23,42,.05);\r\n text-align:left;\r\n }\r\n .phinc-endorse-card h3{\r\n margin:0 0 8px;\r\n font-size:16px;\r\n font-weight:700;\r\n letter-spacing:-.01em;\r\n }\r\n .phinc-endorse-card p{\r\n margin:0;\r\n color:var(--muted);\r\n font-size:14px;\r\n line-height:1.55;\r\n font-weight:300;\r\n }\r\n .phinc-endorse-card a{ color:var(--phinc-blue); text-decoration:none; }\r\n .phinc-endorse-card a:hover{ text-decoration:underline; }\r\n\r\n \/* ====== Case studies cards (3 colonnes) + image au-dessus du titre ====== *\/\r\n .phinc-cs-grid{\r\n display:grid;\r\n grid-template-columns: repeat(3, 1fr);\r\n gap:16px;\r\n margin-top:22px;\r\n }\r\n .phinc-cs-card{\r\n background: var(--card);\r\n border:1px solid var(--line);\r\n border-radius: var(--radius);\r\n padding:18px;\r\n box-shadow: 0 6px 20px rgba(15,23,42,.05);\r\n display:flex;\r\n flex-direction:column;\r\n gap:12px;\r\n overflow:hidden;\r\n }\r\n .phinc-cs-image{\r\n width:100%;\r\n aspect-ratio: 16\/9;\r\n border-radius: 14px;\r\n border:1px solid var(--line);\r\n background: linear-gradient(135deg, rgba(0,0,95,.10), rgba(217,75,159,.10));\r\n margin-bottom:2px;\r\n background-size: cover;\r\n background-position: center;\r\n background-repeat: no-repeat;\r\n }\r\n .phinc-cs-top{\r\n display:flex;\r\n justify-content:space-between;\r\n align-items:center;\r\n gap:10px;\r\n }\r\n .phinc-cs-pill{\r\n font-size:12px;\r\n padding:6px 10px;\r\n border:1px solid var(--line);\r\n border-radius:999px;\r\n background:#fff;\r\n color:var(--muted);\r\n font-weight:400;\r\n white-space:nowrap;\r\n }\r\n .phinc-cs-card h3{\r\n margin:0;\r\n font-size:16px;\r\n font-weight:700;\r\n letter-spacing:-.01em;\r\n line-height:1.25;\r\n }\r\n .phinc-cs-lines{\r\n display:grid;\r\n gap:8px;\r\n margin:0;\r\n padding:0;\r\n list-style:none;\r\n }\r\n .phinc-cs-lines li{\r\n display:flex;\r\n gap:10px;\r\n align-items:flex-start;\r\n color:var(--muted);\r\n font-size:14px;\r\n line-height:1.45;\r\n font-weight:300;\r\n }\r\n .phinc-cs-dot{\r\n width:8px;\r\n height:8px;\r\n border-radius:999px;\r\n background: linear-gradient(135deg, var(--phinc-blue), var(--phinc-pink));\r\n flex: 0 0 auto;\r\n margin-top:7px;\r\n }\r\n .phinc-cs-cta{\r\n margin-top:auto;\r\n display:flex;\r\n justify-content:flex-start;\r\n padding-top:6px;\r\n }\r\n\r\n .phinc-btn.is-placeholder{\r\n pointer-events:none;\r\n opacity:1;\r\n }\r\n\r\n \/* ====== NEW: Floating side menu (5 CTA) ====== *\/\r\n .phinc-side{\r\n position: fixed;\r\n left: 3vh;\r\n top: 50%;\r\n transform: translateY(-50%);\r\n z-index: 9999;\r\n display: flex;\r\n flex-direction: column;\r\n gap: 14px;\r\n \r\n background: none;\r\n \r\n box-shadow: none;\r\n }\r\n .phinc-side a{\r\n display: inline-flex;\r\n align-items: center;\r\n gap: 10px;\r\n padding: 8px 14px;\r\n border-radius: 999px;\r\n background: #fff;\r\n border: 1px solid var(--line);\r\n text-decoration: none;\r\n color: var(--ink);\r\n font-size: 12px;\r\n font-weight: 400;\r\n white-space: nowrap;\r\n transition: transform .16s ease, box-shadow .16s ease, border-color .16s ease;\r\n }\r\n .phinc-side a .phinc-side-dot{\r\n width: 10px; height: 10px; border-radius: 999px;\r\n border: 2px solid var(--phinc-blue);\r\n background: #fff;\r\n flex: 0 0 auto;\r\n }\r\n .phinc-side a:hover{\r\n transform: scale(1.06);\r\n box-shadow: 0 12px 30px rgba(15,23,42,.12);\r\n border-color: rgba(0,0,95,.22);\r\n }\r\n\r\n \/* Optional: active state (JS will toggle) *\/\r\n .phinc-side a.is-active{\r\n border-color: rgba(0,0,95,.35);\r\n box-shadow: 0 12px 30px rgba(15,23,42,.14);\r\n }\r\n .phinc-side a.is-active .phinc-side-dot{\r\n background: var(--phinc-blue);\r\n }\r\n\r\n \/* Hide side menu on small screens *\/\r\n @media (max-width: 980px){\r\n .phinc-side{ display:none; }\r\n }\r\n\r\n @media (max-width: 920px){\r\n .phinc-hero-grid, .phinc-split, .phinc-cta{ grid-template-columns: 1fr; }\r\n .phinc-split.reverse .phinc-split-media{ order: 0; }\r\n .phinc-cards, .phinc-steps-grid, .phinc-proof{ grid-template-columns: 1fr; }\r\n .phinc-endorse-grid{ grid-template-columns: 1fr; }\r\n .phinc-cs-grid{ grid-template-columns: 1fr; }\r\n .phinc-h1{ font-size:36px; }\r\n }\r\n <\/style>\r\n\r\n \r\n <nav class=\"phinc-side\" aria-label=\"Navigation rapide MIDD\">\r\n <a href=\"#top\" data-target=\"#top\"><span class=\"phinc-side-dot\"><\/span>MIDD Offer<\/a>\r\n <a href=\"#deliverables\" data-target=\"#deliverables\"><span class=\"phinc-side-dot\"><\/span>Benefits<\/a>\r\n <a href=\"#regulatory-endorsement\" data-target=\"#regulatory-endorsement\"><span class=\"phinc-side-dot\"><\/span>Regulatory acceptance<\/a>\r\n <a href=\"#roadmap\" data-target=\"#roadmap\"><span class=\"phinc-side-dot\"><\/span>Roadmap<\/a>\r\n <a href=\"#modules\" data-target=\"#modules\"><span class=\"phinc-side-dot\"><\/span>Custom solutions<\/a>\r\n <\/nav>\r\n\r\n <header class=\"phinc-hero\" id=\"top\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-hero-grid\">\r\n <div>\r\n <div class=\"phinc-eyebrow\"><span class=\"phinc-dot\"><\/span> <b>Complete MIDD offer - from lead optimization to registration<\/b><\/div>\r\n <h2 class=\"phinc-h2\">Optimize your development with a clear and traceable MIDD strategy.<\/h2>\r\n <p class=\"phinc-sub\">\r\n Through integrated quantitative approach applied from the earliest stages of drug development, MIDD (Model-Informed Drug Development) enables the generation of robust predictive models to inform decision-making and guide development through Phase III.\r\n <\/p>\r\n\r\n <div class=\"phinc-actions\">\r\n <a class=\"phinc-btn primary\" href=\"#contact\">Get in touch<\/a>\r\n <a class=\"phinc-btn\" href=\"#roadmap\">See the MIDD roadmap<\/a>\r\n <\/div>\r\n\r\n <div class=\"phinc-badges\">\r\n <span class=\"phinc-badge\">PK\/PD - PopPK<\/span>\r\n <span class=\"phinc-badge\">PBPK<\/span>\r\n <span class=\"phinc-badge\">QSP<\/span>\r\n <span class=\"phinc-badge\">Clinical Trial Simulation<\/span>\r\n <span class=\"phinc-badge\">NCA-CDISC<\/span>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-hero-card\">\r\n <div class=\"phinc-visual\" aria-label=\"Visuel MIDD\"><\/div>\r\n <p class=\"phinc-p\" style=\"margin-top:14px;\">\r\n Our experts support you from the earliest development stages through regulatory submission.\r\n <\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/header>\r\n\r\n <section class=\"phinc-section\" id=\"deliverables\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-kicker\">What you earn<\/div>\r\n <h2 class=\"phinc-h2\">Evidence\u2011based decision\u2011making and a well-justified dose.<\/h2>\r\n\r\n <div class=\"phinc-cards\">\r\n <div class=\"phinc-card\">\r\n <h3>Informed strategic decisions<\/h3>\r\n <p>Anticipate outcomes and reduce risk at key stages of development.<\/p>\r\n <div class=\"phinc-mini\"><span>go\/no-go<\/span><span>prioritization<\/span><span>time-to-PoC<\/span><\/div>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Smarter clinical trials<\/h3>\r\n <p>Reduce the number of cohorts, optimize dosing regimens, and shorten timelines.<\/p>\r\n <div class=\"phinc-mini\"><span>FIH<\/span><span>escalation<\/span><span>populations<\/span><\/div>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Strengthened regulatory dialogue<\/h3>\r\n <p>Support your decisions with transparent, model-based evidence.<\/p>\r\n <div class=\"phinc-mini\"><span>dose justification<\/span><span>Q&A authorities<\/span><\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section alt\" id=\"regulatory-endorsement\">\r\n <div class=\"phinc-wrap phinc-endorse\">\r\n <div class=\"phinc-kicker\">Regulatory acceptance<\/div>\r\n <h2 class=\"phinc-h2\">MIDD is supported by regulatory agencies.<\/h2>\r\n <p class=\"phinc-p\">\r\n Regulatory agencies increasingly value MIDD Strategy to improve development efficiency, strengthen dose justification, and support robust decision-making.\r\n <\/p>\r\n\r\n <div class=\"phinc-endorse-grid\">\r\n <div class=\"phinc-endorse-card\">\r\n <h3>\r\n <a href=\"https:\/\/www.fda.gov\/drugs\/development-resources\/model-informed-drug-development-paired-meeting-program\"\r\n target=\"_blank\" rel=\"noopener noreferrer\">\r\n \ud83c\uddfa\ud83c\uddf8 FDA Paired Meeting\r\n <\/a>\r\n <\/h3>\r\n <p>\r\n FDA Paired Meetings enable early alignment of modeling strategies with the agency expectations, helping to secure key decisions and de-risking future submissions.\r\n <\/p>\r\n <\/div>\r\n\r\n <div class=\"phinc-endorse-card\">\r\n <h3>\r\n <a href=\"https:\/\/database.ich.org\/sites\/default\/files\/ICH_M15_Step4_Final_Guideline_2026_0129.pdf\"\r\n target=\"_blank\" rel=\"noopener noreferrer\">\r\n \ud83d\udcd8 ICH M15 \u2013 Guideline MIDD\r\n <\/a>\r\n <\/h3>\r\n <p>\r\n The ICH M15 guideline formalizes the principles of Model-Informed Drug Development and recognizes its central role in development decision-making.\r\n <\/p>\r\n <\/div>\r\n\r\n <div class=\"phinc-endorse-card\">\r\n <h3>\r\n <a href=\"https:\/\/www.ema.europa.eu\/en\/guideline-assessment-reporting-mechanistic-models-used-context-model-informed-drug-development\"\r\n target=\"_blank\" rel=\"noopener noreferrer\">\r\n \ud83c\uddea\ud83c\uddfa EMA & mechanistic models\r\n <\/a>\r\n <\/h3>\r\n <p>\r\n The EMA highlights the value of mechanistic models to strengthen assessment, interpretation, and the robustness of decisions within a MIDD framework.\r\n <\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section alt\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-split\">\r\n <div class=\"phinc-split-media\" aria-label=\"Visuel\"><\/div>\r\n <div>\r\n <div class=\"phinc-kicker\">Approach<\/div>\r\n <h2 class=\"phinc-h2 translation-block\">A comprehensive MIDD strategy,<br>designed to guide your key decisions.<\/h2>\r\n <p class=\"phinc-p\">\r\n From hypothesis definition to final recommendation, we combine modeling, simulation, and regulatory expertise to deliver clear, actionable outputs directly usable by your non-clinical, clinical, and regulatory teams.\r\n <\/p>\r\n <div class=\"phinc-actions\">\r\n <a class=\"phinc-btn primary\" href=\"#roadmap\">Build my development strategy<\/a>\r\n <a class=\"phinc-btn\" href=\"#modules\">Explore modules<\/a>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section\" id=\"roadmap\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-kicker\">MIDD Roadmap<\/div>\r\n <h2 class=\"phinc-h2\">From lead optimization to filing<\/h2>\r\n\r\n <div class=\"phinc-steps\">\r\n <div class=\"phinc-steps-grid\">\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Lead Optimization<\/span>\r\n <\/div>\r\n <p>Speed up candidate and target profile selection. PhinC helps you prioritize options through a mechanistic modeling.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s1\"><span>\u2192<\/span> Discuss framing<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Preclinical<\/span>\r\n <\/div>\r\n <p>Anticipate translation to humans. PhinC helps you secure exposure, starting dose and key assumptions.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s2\"><span>\u2192<\/span> See PBPK \/ PKPD<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Phase I<\/span>\r\n <\/div>\r\n <p>Secure first administration and escalation. PhinC helps you control PK, tolerance and cohort design.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s3\"><span>\u2192<\/span> Optimizing a FIH<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Phase II<\/span>\r\n <\/div>\r\n <p>Accelerate patient proof-of-concept.<\/p>\r\n <p>PhinC helps you optimize the dose-exposure-response relationship for dose selection.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s4\"><span>\u2192<\/span> CTS & PoC<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Phase III<\/span>\r\n <\/div>\r\n <p>Confirm your dosing strategy. PhinC helps you anticipate variability and strengthen the robustness of your results.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s5\"><span>\u2192<\/span> De-risk my Phase III study<\/a>\r\n <\/article>\r\n\r\n <article class=\"phinc-step\">\r\n <div class=\"phinc-step-top\">\r\n <span class=\"phinc-num\">\u2609<\/span>\r\n <span class=\"phinc-stage\">Filing<\/span>\r\n <\/div>\r\n <p>Turn your data into a regulatory argument. PhinC helps you justify dose and regimen with a clear, traceable narrative.<\/p>\r\n <a class=\"phinc-link\" href=\"\/en\/phases\/#s6\"><span>\u2192<\/span> Regulatory Support<\/a>\r\n <\/article>\r\n\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section alt\" id=\"modules\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-split reverse\">\r\n <div>\r\n <div class=\"phinc-kicker\">OUR CUSTOM SOLUTIONS<\/div>\r\n <h2 class=\"phinc-h2\">Tailored approaches, adapted to every development challenge.<\/h2>\r\n <p class=\"phinc-p\">\r\n One objective, one deliverable: from a fast, targeted answer to a full mechanistic model.\nWe tailor the level of complexity to the maturity of your data.\r\n <\/p><br>\r\n <div class=\"phinc-actions\">\r\n <a class=\"phinc-btn primary\" href=\"\/en\/contact\/\">Get in touch<\/a>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-cards\" style=\"margin-top:0;\">\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/service\/pbpk\/\">PBPK - PBBM<\/a><\/h3><p>Extrapolate across species, routes, and populations when data are limited.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/qsp\/\">QSP<\/a><\/h3>\r\n <p>Make fast, consistent, data-driven decisions aligned with clinical objectives.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/poppk-pd\/\">PopPK \/ PK-PD<\/a><\/h3>\r\n <p>Understand systemic exposure and quantify variability to guide dosing.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/service\/qt-qtc\/\">QT\/QTc Analysis<\/a><\/h3>\r\n <p>Provides robust, critical predictions to assess the risk of QTc prolongation.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/service\/pknca\/\">PK NCA CDISC<\/a><\/h3>\r\n <p>Ensures robust, fully compliant analyses for regulatory submission.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3><a href=\"\/en\/clinical-trial-simulation\/\">CTS<\/a><\/h3>\r\n <p>Structures the clinical strategy and secures key development decisions.<\/p>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <section class=\"phinc-section\" id=\"proof\">\r\n <div class=\"phinc-wrap\">\r\n <div class=\"phinc-kicker\">Delivrables<\/div>\r\n <h2 class=\"phinc-h2\">Predictive models to de-risk drug exposure-response<\/h2>\r\n <p class=\"phinc-p\">Concrete recommendations and justification models.<\/p>\r\n\r\n <div class=\"phinc-proof\">\r\n <div class=\"phinc-card\">\r\n <h3>Dose recommendations<\/h3>\r\n <p>Proposed dose(s) and regimen, with defined confidence levels and safety margins.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Scenarios simulation<\/h3>\r\n <p>Test trial scenarios to optimize doses, sample sizes, and endpoints.<\/p>\r\n <\/div>\r\n <div class=\"phinc-card\">\r\n <h3>Regulatory Support<\/h3>\r\n <p>Support development decisions in discussions with health authorities.<\/p>\r\n <\/div>\r\n <\/div>\r\n\r\n <div class=\"phinc-cta\" id=\"contact\">\r\n <div>\r\n <h3>Let's build your MIDD roadmap<\/h3>\r\n <p class=\"translation-block\">Share your development stage, available data, and next target. <br>We will propose a clear strategy, timeline, and deliverables.<\/p>\r\n <div class=\"phinc-actions\" style=\"margin-top:16px;\">\r\n <a class=\"phinc-btn primary\" href=\"\/en\/contact\/\">Get in touch<\/a>\r\n <\/div>\r\n <\/div>\r\n <div class=\"phinc-cta phinc-slim\" style=\"margin-top:0; box-shadow:none;\">\r\n <ul class=\"phinc-list\">\r\n <li><span class=\"phinc-check\"><\/span>Objective & expected decisions<\/li>\r\n <li><span class=\"phinc-check\"><\/span>Mandatory data (minimum viable)<\/li>\r\n <li><span class=\"phinc-check\"><\/span>Delivrables & timelines<\/li>\r\n <li><span class=\"phinc-check\"><\/span>Support for regulatory submission<\/li>\r\n <\/ul>\r\n <\/div>\r\n <\/div>\r\n <\/div>\r\n <\/section>\r\n\r\n <script>\r\n \/\/ Smooth scroll for side menu + active section highlight\r\n (function(){\r\n const menuLinks = Array.from(document.querySelectorAll('.phinc-side a'));\r\n const targets = menuLinks\r\n .map(a => document.querySelector(a.getAttribute('href')))\r\n .filter(Boolean);\r\n\r\n \/\/ Smooth scrolling (works in modern browsers via CSS, but safe fallback)\r\n menuLinks.forEach(a => {\r\n a.addEventListener('click', (e) => {\r\n const id = a.getAttribute('href');\r\n const el = document.querySelector(id);\r\n if(!el) return;\r\n e.preventDefault();\r\n el.scrollIntoView({ behavior: 'smooth', block: 'start' });\r\n });\r\n });\r\n\r\n \/\/ Active state with IntersectionObserver\r\n if('IntersectionObserver' in window && targets.length){\r\n const obs = new IntersectionObserver((entries) => {\r\n entries.forEach(entry => {\r\n if(!entry.isIntersecting) return;\r\n const id = '#' + entry.target.id;\r\n menuLinks.forEach(a => a.classList.toggle('is-active', a.getAttribute('href') === id));\r\n });\r\n }, { root: null, threshold: 0.35 });\r\n targets.forEach(t => obs.observe(t));\r\n }\r\n })();\r\n <\/script>\r\n\r\n<\/section>\r\n<\/body>\r\n<\/html>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>PhinC places modeling and simulation at the heart of your development decisions \u2014 turning data into actionable insights that accelerate timelines and reduce attrition.<\/p>","protected":false},"author":2,"featured_media":3345,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3483","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\n<title>La strat\u00e9gie MIDD - PhinC Group<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phinc-group.com\/en\/midd\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La strat\u00e9gie MIDD - PhinC Group\" \/>\n<meta property=\"og:description\" content=\"PhinC places modeling and simulation at the heart of your development decisions \u2014 turning data into actionable insights that accelerate timelines and reduce attrition.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.phinc-group.com\/en\/midd\/\" \/>\n<meta property=\"og:site_name\" content=\"PhinC Group\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-30T08:45:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2026\/01\/ChatGPT-Image-16-janv.-2026-10_02_20-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1536\" \/>\n\t<meta property=\"og:image:height\" content=\"1024\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.phinc-group.com\/midd\/\",\"url\":\"https:\/\/www.phinc-group.com\/midd\/\",\"name\":\"La strat\u00e9gie MIDD - 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