About us
PhinC was founded in 2008 by four scientists and has been a pioneer in the use of modeling methods for Phase I clinical drug development. PhinC is a scientific consulting firm specializing in drug development supported by modeling approaches.
With expertise in PK/PD, PBPK, biostatistics, and regulatory strategy, our approach is based on:
- Deep learning of data: maximizing the value of all available data for robust simulations and predictions.
- Biotech Agility: adaptability, client proximity, and a culture of fast impact.
- Product Development Expertise: our models are always designed as decision-making tools.
Based in Massy (a suburb of Paris), with a subsidiary in Montreal (Canada), PhinC works with partners around the world.
Our values
At PhinC, your professional fulfilment is our priority. We support you in developing your career within the company, where you can take on professional challenges in a respectful and friendly environment where everyone is valued.
We offer:
- A stimulating environment working with innovative and diverse biotech companies.
- A close-knit team and the opportunity to quickly advance into leadership roles
- Mentorship for young scientists and a collaborative work atmosphere.
Your role
- Develop, validate, and apply PBPK models based on preclinical and clinical data (in silico / in vitro / in vivo).
- Contribute to the design of modeling strategies in support of (pre)clinical development goals (translation, dose selection, formulation, DDI, pediatrics, special populations, etc.).
- Provide robust quantitative analyses and simulations to support regulatory submissions and interactions with agencies.
- Work closely with multidisciplinary teams: pharmacologists, clinicians, statisticians, CMC experts, etc.
- Respond to questions from regulatory agencies during the submission of modeling studies.
- Draft and review scientific reports and regulatory dossiers.
- Contribute to scientific publications and present at internal or external scientific conferences to establish our position as a thought leader
This position allows for remote work up to two days a week, in accordance with company policy.
We offer attractive compensation and benefits, health and life insurance, 8 days of RTT and 25 days of annual leave, participation to public transportation card, gift cards, and preferential access to online CSE platforms.
We are looking for
A PBPK modeling specialist capable of translating preclinical complexity into clinical predictions using quantitative approaches that are both rigorous and pragmatic. You can clearly communicate the conclusions of your models. You like to work in collaborative environments where your analyses directly influence development decisions. You understand that effective modeling requires both scientific rigor and the ability to build trust and credibility with stakeholders.
Qualifications:
Preferably a Ph.D. in pharmaceutical sciences, computational biology, applied mathematics, or a related quantitative field (PharmD or master’s degree in a related field)
- At least 2 years of postdoctoral experience in preclinical/translational PBPK modeling in the pharmaceutical industry or at a CRO (3-5 years of post-degree experience if holding a PharmD or master’s degree)
- In-depth proficiency in PBPK modeling software (Gastroplus)
- Understanding of regulatory requirements (e.g., ICH M15, ICH M12, FDA/EMA guidelines on PBPK)
- Experience contributing to regulatory submissions (EMA/FDA) and scientific publications
- Ability to make pragmatic decisions based on incomplete data
- Excellent interpersonal skills and ability to work within multidisciplinary teams
- Excellent written and oral communication skills in English
