{
    "id": 2422,
    "date": "2025-04-10T15:35:02",
    "date_gmt": "2025-04-10T13:35:02",
    "guid": {
        "rendered": "https:\/\/www.phinc-group.com\/?post_type=service&p=2422"
    },
    "modified": "2026-01-19T19:35:55",
    "modified_gmt": "2026-01-19T18:35:55",
    "slug": "tmdd",
    "status": "publish",
    "type": "service",
    "link": "http:\/\/www.phinc-group.com\/fr\/service\/tmdd\/",
    "title": {
        "rendered": "La mod\u00e9lisation TMDD"
    },
    "content": {
        "rendered": "<div data-elementor-type=\"wp-post\" data-elementor-id=\"2422\" class=\"elementor elementor-2422\" data-elementor-post-type=\"service\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f17da7a e-con-full e-flex e-con e-parent\" data-id=\"3f17da7a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3792729d elementor-widget__width-initial elementor-widget elementor-widget-theme-post-featured-image elementor-widget-image\" data-id=\"3792729d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-featured-image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1350\" height=\"550\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/04\/tmdd-cover.1350x550.webp\" class=\"attachment-2048x2048 size-2048x2048 wp-image-2429\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/04\/tmdd-cover.1350x550.webp 1350w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/04\/tmdd-cover.1350x550-300x122.webp 300w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/04\/tmdd-cover.1350x550-1024x417.webp 1024w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/04\/tmdd-cover.1350x550-768x313.webp 768w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/04\/tmdd-cover.1350x550-18x7.webp 18w\" sizes=\"(max-width: 1350px) 100vw, 1350px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a4bfdb e-flex e-con-boxed e-con e-parent\" data-id=\"5a4bfdb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4df6ae09 e-con-full e-flex e-con e-child\" data-id=\"4df6ae09\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-35b0377b elementor-widget elementor-widget-heading\" data-id=\"35b0377b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Disposition de m\u00e9dicaments avec m\u00e9diation par cible<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18da153a elementor-widget elementor-widget-global elementor-global-424 elementor-widget-image\" data-id=\"18da153a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"112\" height=\"28\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/10\/mini-barre-rose-arrondie.png\" class=\"attachment-full size-full wp-image-2713\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/10\/mini-barre-rose-arrondie.png 112w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/10\/mini-barre-rose-arrondie-18x5.png 18w\" sizes=\"(max-width: 112px) 100vw, 112px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3f839e7f elementor-widget elementor-widget-text-editor\" data-id=\"3f839e7f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Le d\u00e9veloppement r\u00e9ussi de produits biologiques n\u00e9cessite de pr\u00e9dire le plus pr\u00e9cis\u00e9ment possible l&rsquo;exposition humaine. Ceci est plus difficile pour les produits biologiques pour lesquels il est important de comprendre les caract\u00e9ristiques de l&rsquo;affinit\u00e9 avec la cible. En raison de la non-lin\u00e9arit\u00e9 de l&rsquo;exposition, les r\u00e8gles allom\u00e9triques classiques sont non satisfaisantes.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-56199ff4 e-con-full e-flex e-con e-child\" data-id=\"56199ff4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-300977a8 elementor-widget elementor-widget-text-editor\" data-id=\"300977a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Des mod\u00e8les m\u00e9canistes d\u00e9crivant de mani\u00e8re quantitative les interactions m\u00e9dicament-cible sont n\u00e9cessaires pour une simulation et une pr\u00e9vision plus pr\u00e9cises.<\/p><p>Le\u00a0<strong>TMDD (target mediated drug disposition)<\/strong>\u00a0est le ph\u00e9nom\u00e8ne dans lequel un m\u00e9dicament se lie avec une forte affinit\u00e9 \u00e0 son site pharmacologique cible (tel qu&rsquo;un r\u00e9cepteur) \u00e0 un point tel que cela affecte ses caract\u00e9ristiques pharmacocin\u00e9tiques (PK).<\/p><p><img decoding=\"async\" class=\"size-medium wp-image-2424 alignright\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/04\/antibody-drug-300x176.png\" alt=\"\" width=\"300\" height=\"176\" \/><\/p><p>La liaison \u00e0 la cible et l\u2019\u00e9limination subs\u00e9quente des complexes m\u00e9dicament-cible pourraient affecter \u00e0 la fois la distribution et l\u2019\u00e9limination du m\u00e9dicament, et entra\u00eener une non-lin\u00e9arit\u00e9 de la PK en fonction de la dose. Ainsi, la pharmacocin\u00e9tique est souvent lin\u00e9aire \u00e0 fortes doses et non lin\u00e9aire \u00e0 de faibles doses.<\/p><p>Les structures de\u00a0<strong>mod\u00e8le de TMDD<\/strong>\u00a0sont g\u00e9n\u00e9ralement d\u00e9termin\u00e9es par des facteurs tels que :<\/p><ul><li>la voie d&rsquo;administration du m\u00e9dicament (intraveineuse, orale ou autre),<\/li><li>la distribution du m\u00e9dicament (nombre de compartiments),<\/li><li>l&#8217;emplacement de la cible (plasma, tissus, \u2026)<\/li><li>et la cin\u00e9tique de liaison (vitesse, affinit\u00e9, r\u00e9versibilit\u00e9 de la liaison, cible unique ou non, voies d&rsquo;\u00e9limination, &#8230;).<\/li><\/ul><p>Les profils de concentration en fonction du temps d&rsquo;un m\u00e9dicament donn\u00e9 peuvent ne pas afficher toutes les phases, en fonction de la structure du mod\u00e8le et d&rsquo;autres facteurs, notamment la cin\u00e9tique de liaison, les taux de renouvellement des cibles, l&rsquo;\u00e9limination du m\u00e9dicament et le complexe m\u00e9dicament-cible.<\/p><p>Un autre facteur commun est la sensibilit\u00e9 de d\u00e9tection de la bioanalyse. Des limites de d\u00e9tection \u00e9lev\u00e9es peuvent limiter la d\u00e9tection \u00e0 l&rsquo;extr\u00e9mit\u00e9 inf\u00e9rieure des profils.<\/p><p>Chaque candidat m\u00e9dicament biologique pr\u00e9sente un m\u00e9canisme et des performances uniques, PhinC Development peut aider \u00e0 d\u00e9terminer\u00a0<strong>quand et comment utiliser un mod\u00e8le TMDD<\/strong>\u00a0pour aider \u00e0 pr\u00e9dire puis caract\u00e9riser sa pharmacocin\u00e9tique chez le sujet sain ou chez le patient sur l&rsquo;\u00e9ventail de dose qui sera n\u00e9cessaire \u00e0 consid\u00e9rer dans le d\u00e9veloppement.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e16bd57 e-con-full e-flex e-con e-child\" data-id=\"5e16bd57\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-71301e9c e-con-full e-flex e-con e-child\" data-id=\"71301e9c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-6a839eac e-con-full e-flex e-con e-child\" data-id=\"6a839eac\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-72e12191 elementor-widget elementor-widget-heading\" data-id=\"72e12191\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Fiche de vente et articles<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-789043d3 e-con-full e-flex e-con e-child\" data-id=\"789043d3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-212cd3ff elementor-widget__width-auto elementor-widget elementor-widget-text-editor\" data-id=\"212cd3ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En savoir plus sur<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-538cdd23 e-con-full e-flex e-con e-child\" data-id=\"538cdd23\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-69410c34 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"69410c34\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li 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data-widget_type=\"posts.cards\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-posts-container elementor-posts elementor-posts--skin-cards elementor-grid\" role=\"list\">\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-210 post type-post status-publish format-standard has-post-thumbnail hentry category-insights service-associe-modelisation-integree\" role=\"listitem\">\n\t\t\t<div class=\"elementor-post__card\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"http:\/\/www.phinc-group.com\/fr\/10-bonnes-raisons-dutiliser-la-modelisation-et-la-simulation\/\" tabindex=\"-1\" ><div class=\"elementor-post__thumbnail\"><img loading=\"lazy\" decoding=\"async\" width=\"744\" height=\"494\" src=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/10-GOOD-reasons.jpg\" class=\"attachment-medium_large size-medium_large wp-image-4802\" alt=\"\" srcset=\"https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/10-GOOD-reasons.jpg 744w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/10-GOOD-reasons-300x199.jpg 300w, https:\/\/www.phinc-group.com\/wp-content\/uploads\/2025\/01\/10-GOOD-reasons-18x12.jpg 18w\" sizes=\"(max-width: 744px) 100vw, 744px\" \/><\/div><\/a>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"http:\/\/www.phinc-group.com\/fr\/10-bonnes-raisons-dutiliser-la-modelisation-et-la-simulation\/\" >\n\t\t\t\t10 bonnes raisons d&rsquo;utiliser la Mod\u00e9lisation et la Simulation dans le d\u00e9veloppement de m\u00e9dicament\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>L&rsquo;expertise en mod\u00e9lisation est une brique indispensable pour une strat\u00e9gie de d\u00e9veloppement de m\u00e9dicaments optimale.<\/p>\n\t\t<\/div>\n\t\t\n\t\t<a class=\"elementor-post__read-more\" 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